As pharmacodynamic drug-drug interactions (PD DDIs) could lead to severe adverse effects in patients, it is important identify potential PD DDIs drug development. The signaling starting from targets propagated through protein-protein interaction (PPI) networks. occur by close interference on the same or within pathways as well distant cross-talking pathways. However, most of previous approaches have considered only measuring distances between comparing target neighbors. We applied a random...

The Swanson's ABC model is powerful to infer hidden relationships buried in biological literature. However, the inadequate relations with context information. In addition, generates a very large amount of candidates from text, and it semi-automatic, labor-intensive technique requiring human expert's manual input. To tackle these problems, we incorporate terms between AB interactions BC interactions.We propose 3 steps discover meaningful drugs diseases: 1) multi-level (gene, drug, disease,...

Three-dimensional (3D) culture platforms have been adopted in a high-throughput screening (HTS) system to mimic vivo physiological microenvironments. The automated dispenser has established commercially enable spotting or distributing non-viscous viscous biomaterials onto microplates. However, there are still challenges the precise and accurate dispensation of cells embedded hydrogels such as Alginate- Matrigel-extracellular matrices. We developed improved an contact-free dispensing machine,...

.Consider a robust retirement decision problem for risk- and ambiguity-averse investor concerned about return ambiguity in risky asset prices. When the aims to maximize worst-case scenario of his/her utility derived from consumption bequest, we propose an optimal \(G\)-stopping approach optimization dual space with risk ambiguity. Under \(G\)-expectation framework, consider reflected \(G\)-BSDE upper obstacle, which allows us formulate parabolic obstacle stopping problem. From dynamic result...

Consider a robust consumption-investment problem for risk- and ambiguity-averse investor who is concerned about return ambiguity in risky asset prices. When the aims to maximize worst-case scenario of his/her objective, we propose dual approach optimization economy with volatility ambiguity. Using $G$-expectation framework, establish duality theorem bridge between primal ambiguity, hence characterize strategy general class utility functions subject nonnegative consumption rate wealth...

We study an optimal consumption, investment, life insurance, and retirement decision of economic agent who has option to retire early any time before the mandatory date. conduct a thorough theoretical analysis for problem with general utility function in presence date, which leads stopping finite horizon. Furthermore, different marginal consumption after is considered, can provide explanation retirement-consumption puzzle, while it makes technically more challenging. Based on theory partial...

We address the ways in which a government subsidy and labor flexibility affect optimal policies retirement decisions using continuous-time theoretical model with endogenous labor/leisure choice. In response to subsidy, working agents increase their overall consumption, leisure spending, investment risky assets, is an intuitive finding. Labor has marginal effects on consumption when agent's wealth insufficient. However, agent enough enjoy maximum leisure, increases spending reduces...

Other SectionsABSTRACTINTRODUCTIONRESULTSDISCUSSIONMATERIALS AND METHODSACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGURESREFERENCES

The border region of South Korea has undergone dramatic social and environmental changes since the late 1990s with shifts in governmental regimes. Under proliberal government (1997–2007) that enhanced economic ties between North Korea, was open for introducing new people industries. With a conservative regime past decade (2007–2017), challenges emerged region. Such were not uniformly present throughout different areas, however. We examined spatial transformation using sociodemography,...

Interactions between biological entities such as genes, proteins and metabolites, so called pathways, are key features to understand molecular mechanisms of life. As pathway information is being accumulated rapidly through various knowledge resources, there growing interests in maintaining the integrity heterogeneous databases. Here, we defined conflict a status where two contradictory pieces evidence (i.e. 'A increases B' decreases B') coexist same pathway. This damages unity that inference...

에너지 균형조건을 고려하여 중형 태양광 추진 고고도 장기체공 무인기의 다분야 통합 최적설계를 수행하였다. 공력 모델로 Vortex Lattice Method (VLM)를 사용하였으며 Cruz가 제안한 중량분석 모델로서 비행체 중량을 추정하였다. 비행체의 세로 정안정성 확보를 위하여 꼬리날개의 부피비를 고정하고 정안정성을 확보할 수 있도록 위치를 결정하였다. 태양전지, 축전지, 비행 고도 등 사용가능한 에너지와, 필요에너지를 비교하여 24시간 지속비행 가능성을 태양 입사 에너지는 북위 <TEX>$36^{\circ}$</TEX>의 여름을 기준으로 하였으며, 주간비행 중 태양에너지를 이용한 상승비행으로 확보한 위치에너지를 이용하여 야간 비행에 필요한 에너지를 보충하였다. 이를 바탕으로, 주요 치수, 중량 분포 최적 설계와 장기체공을 실현할 있는 비행전략을 제시하였다. A MDO study of a midium-sized solar powered High Altitude Long...

In the present study, a methodology for conducting system-level analysis of fan–motor assembly in vacuum cleaner is presented. This system consisted three components, fan, motor, and flow resistance or cleaner. The combined characteristics fan motor were obtained from torque matching at constant throttling condition, pressure drop was implemented under rate to account resistance. By combining these two steps, performance could be predicted over whole range operation, based on each component....

The Swanson's ABC model is powerful to infer hidden relationships buried in biological literatures. However, the inadequate relations with context information. In addition, generates very large amount of candidates from text, and it semi-automatic, labor intensive technique requiring human expert's input. this paper, we propose a novel interaction inference that incorporates term vectors into discover meaningful, relationships. Our hypothesis context-based relation extraction between AB...