A5021590843- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Body Contouring and Surgery
- Extracellular vesicles in disease
- Esophageal Cancer Research and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Psychosomatic Disorders and Their Treatments
- Fibroblast Growth Factor Research
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
- Meat and Animal Product Quality
- Genomics and Chromatin Dynamics
- Gastroesophageal reflux and treatments
- Molecular Biology Techniques and Applications
- Vitamin D Research Studies
Yonsei University
2003-2024
Korea University
2008
Pusan National University Hospital
2007
Seoul National University Bundang Hospital
2007
National Cancer Center
2005-2006
Abstract Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects potential strategy the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) very important development phenotype activation its thermogenic program. To study effects cyclic nucleotides on energy homeostatic mechanisms, mice were generated targeted inactivation nucleotide phosphodiesterase 3b (Pde3b) gene, encodes PDE3B, an enzyme that catalyzes...
<b>Objective: </b> To determine the incidence and characteristics of hyperventilation-induced nystagmus (HIN) in cerebellopontine angle (CPA) tumors unilateral peripheral vestibulopathy (UPV), to elucidate differential contribution hyperventilation bring out vestibular asymmetry between acute chronic phases UPV. <b>Methods: We recorded horizontal HIN 33 patients with CPA 145 The UPV included either (7 days or less from symptom onset, n = 47) (more than 7 98) phases. <b>Results: was higher...
To investigate the effects of electro-acupuncture (EA) treatment on regions remote from application, we measured cellular, enzymatic, and transcriptional activities in various internal tissues healthy rats. The EA was applied to well-identified acupoint ST36 leg. After activity natural killer cells spleen, gene expression hypothalamus, antioxidative enzymes liver red blood cells. increased cell spleen by approximately 44%. It also induced genes related pain, including 5-Hydroxytryptamine...
Duodenal mucosal resurfacing (DMR) by thermal ablation of the duodenal mucosa is a minimally invasive endoscopic procedure for controlling metabolic syndrome (MS). However, energy can cause adverse effects due to deep injury, necessitating an additional lifting process, which complicate procedures. Therefore, we aimed develop similar using non-thermal photodynamic therapy (PDT) DMR highly functional metal stent covered with photosensitizers (PSs) minimize potential risks injury. We developed...
Histone H3 lysine 9 (H3-K9) methylation and DNA are important features of mammalian heterochromatin. Suppressor variegation 3-9 homolog 2 (SUV39H2) is the histone methyltransferase that required to methylate H3-K9, leading transcriptional repression or silencing target genes. In this study, we investigated association SUV39H2 polymorphisms risk lung cancer. From results PCR direct sequencing, eight single nucleotide (SNPs) were identified in Korean population. a hospital-based study 346...
To identify transcriptional markers for beef traits related to meat tenderness and moisture, we measured the transcriptome of Longissimus dorsi skeletal muscle in 10 Korean native cattle (KNC). We analyzed correlation between measurements four different traits, shear force (SF), water holding capacity (WHC), cooking loss (CL), loin eye area (LEA). obtained non-overlapping unique panels genes showing strong correlations (|r| > 0.8) with SF, WHC, CL, LEA, respectively. Functional studies these...
Small cell lung cancer (SCLC) frequently shows a loss of heterozygosity (LOH) on chromosome 15q. In order to define the commonly affected region 15q, we tested 23 primary SCLCs by microsatellite analysis. By analyzing 43 polymorphic markers located found that 14 (60.8%) tumors exhibited LOH in at least one markers. Two (14.3%) were have more than 50% was observed five deleted regions Of those regions, from D15S1012 D15S1016 most frequent (47.8%). also 20-30% four other D15S1031 D15S1007,...
Jaesung Seo, Hyun Jung Kee, Hye Ji Choi, Jae Eun Lee, Soo-Yeon Park, Seung-Hyun Mi-Hyeon Jeong, Garam Guk, SooYeon Kyung-Chul Yoon Young Hyunki Kim, Sung Hoon Noh, Ho-Geun Yoon, and Jae-Ho Cheong. BMB Reports 2018;51:255-60. https://doi.org/10.5483/BMBRep.2018.51.5.046
Recurrent or metastatic head and neck squamous cell carcinoma ( HNSCC ) has been a longstanding challenge for oncologists, current treatments still have limited efficacy. ERK is aberrantly overexpressed activated in . Herein, we aimed to investigate the cause of therapeutic effect selumetinib, selective inhibitor MEK , as / reactivation inevitably occurs. We assessed effects combining selumetinib with fibroblast growth factor receptor 3 FGFR 3) PD 173074) on tumor growth. Selumetinib...
Abnormal tumor cell metabolism is a consequence of alterations in signaling pathways that provide critical selective advantage to cancer cells. However, systematic characterization the metabolic and altered stem-like cells (CSCs) currently lacking. Using nuclear magnetic resonance mass spectrometry, we profiled whole-cell metabolites pair parental (P-231) (S-231), then integrated with whole transcriptome profiles. We identified elevated NAAD+ S-231 along coordinated increased expression...
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Abstract Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its aggressive nature and the limited efficacy of existing treatments. The complex interactions within tumor microenvironment (TME) cell itself remain poorly understood, particularly in relation cancer cachexia, which is characterized by weight loss, muscle wasting, systemic inflammation, metabolic disturbances, has a profound impact on PDAC outcomes. This study investigated role TME development cachexia...
9582 Background: Histone methylation is an important step for forming heterochromatin and the regulation of gene functions. SUV39H methyltrasferase, which targets histone H3 lysine 9, has two types genes in human, SUV39H1 SUV39H2. was found to interact with Rb protein Suv39h1/h2 double knockout mice had increased risk lymphoma. We investigated relation SUV39H2 polymorphisms lung cancer. Methods: Among 8 novel SNPs identified on through direct PCR sequence, we examined 6004G/C (3’ UTR)...
Background Loss of the short arm chromosome 16 is a frequent event in various cancers, which suggests presence tumor suppressor gene(s) there. To map precise loci on for further positional cloning efforts, we tested 23 primary small cell lung cancers. Methods The DNAs extracted from paraffin embedded tissue blocks with and corresponding control were investigated. Twenty polymorphic microsatellite markers located used analysis. Results We found that six (26.1%) tumors exhibited LOH at least...