A5050505435- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Advanced NMR Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Advanced MRI Techniques and Applications
- Solid-state spectroscopy and crystallography
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Atomic and Subatomic Physics Research
- Nanoparticle-Based Drug Delivery
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- NMR spectroscopy and applications
- Pharmacology and Obesity Treatment
- Chemical Reactions and Isotopes
- Electron Spin Resonance Studies
- Body Contouring and Surgery
- Neuroblastoma Research and Treatments
- 3D Printing in Biomedical Research
- Diet, Metabolism, and Disease
- Radiopharmaceutical Chemistry and Applications
Yonsei University
2015-2024
Kyungpook National University
2010-2013
A challenge in using plasmonic nanostructure-drug conjugates for thermo-chemo combination cancer therapy lies the huge size discrepancy; difference can critically differentiate their biodistributions and hamper synergistic effect. Properly tuning wavelength photothermal typically results nanostructure reaching ∼100 nm. We report a new platform that consists of relatively small 10 nm pH-responsive spherical gold nanoparticles conjugated doxorubicins. They are designed to form aggregates mild...
A facile method of preparing triple-modality, optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence based on radionuclides showed great potential as a new optical modality. The complementary nature the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs. Detailed facts importance to specialist readers are published...
The mechanisms underlying type 2 diabetes resolution after Roux-en-Y gastric bypass (RYGB) are unclear. We suspected that glucose excretion may occur in the small bowel based on observations humans. aim of this study was to evaluate serum intestine and its contribution homeostasis bariatric surgery.2-Deoxy-2-[18F]-fluoro-D-glucose (FDG) measured RYGB-operated or sham-operated obese diabetic rats. Altered metabolism targeted RNA sequencing performed areas high low FDG uptake ileum common...
An indirect method for in vivo T 2 mapping of 13 C–labeled metabolites using and * information water protons obtained a priori is proposed. The values C are inferred the relationship to ′ coexisting 1 H metabolites, which measured routine hyperpolarized CSI data. concept verified with phantom studies. Simulations were performed evaluate extent estimation accuracy due errors other measurements. Also, bias from data was studied. In experiments brains normal rats rat C6 glioma. Simulation...
To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification hyperpolarized 13 C chemical shift imaging (CSI) mouse liver at 9.4 T.The trade-off between amount using T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations flow-suppressed non-flow-suppressed acquisitions each repetition time developed applied to tumor-bearing mice via injection [1-13 C] pyruvate.The vivo results velocity-optimized...
The Roux-en-Y gastric bypass (RYGB) is highly effective in the remission of obesity and associated diabetes. mechanisms underlying type 2 diabetes mellitus after RYGB remain unclear. This study aimed to evaluate changes continuous dynamic FDG uptake patterns examine correlation between glucose metabolism its transporters variable endocrine organs using 18 F-fluoro-2-deoxyglucose positron emission tomography images. Increased specific organs, such as small intestine various fat tissues,...
Pituitary adenoma-induced excess endocrine growth hormone (GH) secretion can lead to breast cancer development and metastasis. Herein, we used an acromegaly mouse model investigate the role of GH on triple-negative (TNBC) Additionally, aimed elucidate molecular mechanism transcription factor 20 (TCF20)/nuclear erythroid 2-related 2 (NRF2) signaling-mediated aggressiveness metastasis TNBC. Excess induced TCF20 activates NRF2 NRF2-target genes facilitate TNBC Inhibition receptor (GHR) activity...
Abstract Disclosure: C. Ku: None. Kang: J. Oh: E. Wang: H. Song: K. Park: B. Kim: S. You: Lee: Background: Forty to sixty percent of acromegalic patients undergo medical treatment, utilizing somatostatin analogues, dopamine agonists, and GH receptor (GHR) antagonists. The GHR antagonist, pegvisomant exhibits the most robust efficacy in reducing IGF-1 levels patients. However, faces several clinical limitations, such as poor compliance due necessity daily injections. This study aimed develop...
Hyperpolarized C magnetic resonance spectroscopy imaging (MRSI) is an emerging technique to observe the metabolic activities of tissue after injecting hyperpolarized C-labeled substrates (1, 2). Due a low natural abundance C, special and equipment (dynamic nuclear polarization [DNP]), are required enhance This Open Access article distributed under terms Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted...
An enzyme mixture (EM) of glucose oxidase, glucosyl transferase, and fructosyl transferase can regulate absorption into the body by converting carbohydrates in food to indigestible oligosaccharides. We evaluated antidiabetic effects repeated oral administration EM db/db mice. Seven-week-old mice were divided control, voglibose, groups. Drugs administered orally mixed with limited feed for one month. Glucose levels measured every week. A meal tolerance test was conducted after overnight...
Pituitary adenoma-induced excess growth hormone (GH) secretion can lead to breast cancer development and increased metastasis. Herein, we used an acromegaly mouse model investigate the role of GH in invasion metastasis illustrate molecular mechanism transcription factor 20 (TCF20)/nuclear erythroid 2-related 2 (NRF2) signaling-mediated aggressiveness . We found that TCF20 activates NRF2 NRF2-related genes facilitate Inhibition receptor (GHR) activity using GHR-antagonist pegvisomant or...
Abstract Disclosure: C. Kang: None. J. Oh: E. Wang: S. Lee: Nam: Hong: Ku: Background: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPAR γ) ligand, are used to treat type II diabetes. Over the last few years, PPAR has received much attention for its ability exert variable tumors. Objective: The aim of this study is investigate anti-tumor effect rosiglitazone on prolactin secreting pituitary adenomas and mechanism. Materials & Methods: Lactotroph cell line...
Abstract Disclosure: J. Oh: None. C. Kang: E. Wang: S. Lee: Nam: Ku: Introduction Acromegaly is a rare disease characterized by chronic growth hormone (GH) and insulin-like factor-1 hypersecretion. In previous studies, it known that the incidence of breast cancer increases in patients with acromegaly. For cancers, autocrine GH GHR are expressed primary lesion, which significantly increased metastatic one. To date, however, precise mechanism endocrine metastasis has not been defined. This...
Abstract Disclosure: J. Nam: None. C. Kang: Oh: E. Wang: S. Lee: Hong: Ku: Object: Although the effect of metformin is widely known, little research has been performed on clinical significance and potential mechanism increased intestinal glucose uptake which commonly found in [18F]-fluoro-D-glucose (FDG) positron emission tomography. The aim this study to assess altered metabolism combined colon terminal small intestine after treatment. Material Method: Radioactivity FDG was measured treated...