A5101637458- Ocular Surface and Contact Lens
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Corneal Surgery and Treatments
- RNA modifications and cancer
- Oral microbiology and periodontitis research
- Chronic Lymphocytic Leukemia Research
- Tuberculosis Research and Epidemiology
- Chronic Myeloid Leukemia Treatments
- Advanced Glycation End Products research
- Lymphoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Dermatology and Skin Diseases
- Genomics and Rare Diseases
- Olfactory and Sensory Function Studies
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- Salivary Gland Disorders and Functions
- Advancements in Transdermal Drug Delivery
- Ocular Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Genomic variations and chromosomal abnormalities
- Biopolymer Synthesis and Applications
- Food Allergy and Anaphylaxis Research
St. Vincent's Hospital
2024
Ulsan National Institute of Science and Technology
2020-2024
Seoul National University
2024
Gachon University
2001-2022
Bioleaders (South Korea)
2017
We present the initial phase of Korean Genome Project (Korea1K), including 1094 whole genomes (sequenced at an average depth 31×), along with data 79 quantitative clinical traits. identified 39 million single-nucleotide variants and indels which half were singleton or doubleton detected Korean-specific patterns based on several types genomic variations. A genome-wide association study illustrated power whole-genome sequences for analyzing traits, identifying nine more significant candidate...
Periodontitis is a widespread chronic inflammatory disease caused by interactions between periodontal bacteria and homeostasis in the host. We aimed to investigate performance reliability of machine learning models predicting severity periodontitis. Mouthwash samples from 692 subjects (144 healthy controls 548 generalized periodontitis patients) were collected, genomic DNA was isolated, copy numbers nine pathogens measured using multiplex qPCR. The are as follows: Porphyromonas gingivalis...
Dental caries are one of the chronic diseases caused by organic acids made from oral microbes. However, there was a lack knowledge about microbiome Korean children. The aim this study to analyze metagenome data obtained children and discover bacteria highly related dental with machine learning models. Saliva plaque samples 120 aged below 12 years were collected. Bacterial composition identified using Illumina HiSeq sequencing based on V3-V4 hypervariable region 16S rRNA gene. Ten major...
Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate among tumors. At time of diagnosis, more than 80% PDACs are considered to be surgically unresectable, and there is an unmet need for treatment options in these inoperable PDACs. This study aimed establish a patient-derived organoid (PDO) platform from EUS-guided fine-needle biopsy (EUS-FNB) collected at diagnosis determine its clinical applicability timely unresectable PDAC.
To compare the short-term therapeutic effects of topical corticosteroids in patients with refractory dry eye disease (DED) according to tear matrix metalloproteinase 9 (MMP-9) point-of-care positivity.This study was conducted on 137 who were referred from other clinics, complaining irresponsive DED or acute flares despite routine treatment cyclosporin diquafosol. The received for 1 month. evaluated by SANDE (Symptom Assessment Dry Eye) questionnaire, film breakup time, ocular surface...
Abstract We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal model was established by applying 0.1 N sodium hydroxide (NaOH), followed treatment with 8-oxo-dG, 0.1% fluorometholone (FML), 1% prednisolone acetate (PDE), or phosphate-buffered saline (PBS) twice daily. One week later, clinical histological status cornea were assessed. Transcript levels inflammatory cytokines nicotinamide...
The ocular surface is continuously exposed to various environmental factors, and innate adaptive immunity play crucial roles in diseases (OSDs). Previously, we have reported that the topical application of RCI001 affords excellent anti-inflammatory antioxidant effects dry eye disease chemical burn models. In this study, examined inhibitory on Rac1 NLRP3 inflammasomes vitro vivo . Following RAW264.7 Swiss 3T3 cells, measured activity using a glutathione-S-transferase (GST) pull-down assay...
To evaluate the therapeutic effects of topical RCI001 (RCI) and compare its efficacy with that 1% prednisolone acetate (PDE) 5% Lifitegrast in a modified mixed dry eye disease (DED) model. The environmental DED model was induced BALB/c mice chamber scopolamine. eyes were treated topically phosphate buffered saline (PBS), PDE, or RCI twice daily for 1 week. Ocular surface staining (OSS), tear secretion, inflammatory cytokines ocular lacrimal gland, immunofluorescence conjunctiva cornea(CC)...
Background Pyrazinamide (PZA) usage has been associated with adverse drug reactions, prompting its avoidance in treating elderly tuberculosis (TB) patients. This study aims to examine whether the administration of PZA is poor outcomes during TB treatment among individuals. Methods A retrospective analysis was undertaken on data collected from a prospective cohort conducted between July 2019 and June 2023, which involved patients 18 institutions across Republic Korea. The aimed assess impact...
Aplastic anemia (AA) is a lethal hematological disorder; however, its pathogenesis not fully understood. Although immunosuppressive therapy (IST) major treatment option for AA, one-third of patients do respond to IST and resistance mechanism remains elusive. To understand AA resistance, we performed single-cell RNA sequencing (scRNA-seq) bone marrow (BM) from healthy controls with at diagnosis. We found that CD34 + early-stage erythroid precursor cells PROM1 hematopoietic stem were...
Malignant pleural effusion (MPE) is a complication of lung cancer that can be used as an alternative method for tissue sampling because it generally simple and minimally invasive. Our study evaluated the diagnostic potential non-small-cell carcinoma (NSCLC)-associated MPE in terms understanding tumor heterogeneity identifying response factors EGFR tyrosine kinase inhibitor (TKI) therapy. We performed single-cell RNA sequencing analysis 31,743 cells isolated from MPEs 9 patients with NSCLC (5...
To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model. In 40 male Sprague-Dawley rats, we induced using filter paper soaked 0.2N sodium hydroxide. The rats were then treated with topical 0.5% 1.0% or PDRN twice day for 2 weeks. Corneal integrity rate measured at 0, 3, 5, 7, 10, 14. Histologic immunohistochemistry findings also assessed. Both RCI001 groups showed significantly more compared to control group...
Abstract Background Pyrazinamide (PZA) usage has been associated with adverse drug reactions, prompting its avoidance in treating elderly tuberculosis (TB) patients. This study aims to examine whether the administration of PZA is poor outcomes during TB treatment among individuals. Methods A retrospective analysis was undertaken on data collected from a prospective cohort conducted between July 2019 and June 2023, which involved patients 18 institutions across Republic Korea. The aimed...
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Background: Papillary renal cell carcinoma type 2 (PRCC2) is refractory to systemic treatment and has a dismal prognosis. Previous studies showed that genetic alterations in PRCC2 were heterogeneous regardless of germline or somatic mutations. In this study, we aimed perform precision based on information. Methods: We performed exome genome sequencing tumor tissues matched normal samples. Based data, treated patients with metastatic using oncology. Results: Four underwent curative surgery...
Background: Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate among tumors, and there is an unmet need for treatment options inoperable tumors. The aims of study were to establish a PDAC patient-derived organoid (PDO) model from minimal endoscopic ultrasonography (EUS)-guided fine needle biopsy (FNB) specimens collected at diagnosis determine its clinical applicability timely unresectable PDAC.Methods: Patients with suspected enrolled prospectively Samsung Medical Center...
e14623 Background: Poly-gamma-glutamic acid (γ-PGA), as a signaling regulator of Toll-like receptor 4 (TLR4), has been shown to induce innate immune responses. In previous non-clinical study, we showed that γ-PGA induces pathway Type 1 interferon, which consequently eliminates various viruses such SARS, hepatitis C virus, influenza etc. To evaluate the clinical efficacy γ-PGA, we’ve investigated antiviral effect on human. retrospective study evaluate, significance g-PGA treatment for vaginal...