A5019051199- Risk and Safety Analysis
- Marine and Coastal Research
- Technology and Data Analysis
- Combustion and Detonation Processes
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Engineering Applied Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Fluid Dynamics and Mixing
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Occupational Health and Safety Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Fire dynamics and safety research
- Fault Detection and Control Systems
- Education, Safety, and Science Studies
- Polyamine Metabolism and Applications
- Vibrio bacteria research studies
- Airway Management and Intubation Techniques
- Minerals Flotation and Separation Techniques
- Pneumonia and Respiratory Infections
- Cancer Genomics and Diagnostics
Chonnam National University Hospital
2016-2024
Chonnam National University
2012-2024
Korea Research Institute of Bioscience and Biotechnology
2024
Chonnam National University Hwasun Hospital
2016-2023
Cancer Clinic
2023
Pulmonary Associates
2022
Chung-Ang University
2022
Weatherford College
2021
Yonsei University
2015-2020
Seoul Institute
2020
Relatively little is known about the efficacy and safety of programmatic use bedaquiline delamanid in multidrug-resistant tuberculosis (MDR-TB) treatment. This study evaluated 61 patients with MDR-TB treated (n=39), (n=11) or both, either sequentially (n=10) coadministration (n=1), for >1 month, combined a World Health Organization-recommended regimen. Of these, 49 (80.3%) were male 12 (19.7%) female. The median (interquartile range (IQR)) age was 53 (38.5–61.0) years. 42 (68.9%) had...
For patients requiring prolonged mechanical ventilation (PMV), weaning is difficult and mortality very high. PMV has been defined recently, by consensus, as constituting ≥21 consecutive days of (MV) for ≥6 hours per day. This study aimed to evaluate the clinical factors predicting failure in undergoing medical intensive care unit (ICU).We retrospectively reviewed laboratory characteristics 127 who received MV more than 21 ICU at Chonnam National University Hospital South Korea between...
Fluorescence in situ hybridization (FISH) using tumor tissue is the gold standard for detection of anaplastic lymphoma kinase (ALK) rearrangement non-small cell lung cancer (NSCLC). However, this method often not repeatable due to difficulties acquisition tissues. Blood-based liquid biopsy reverse transcription polymerase chain reaction (RT-PCR) expected be useful overcome limitation. Here, we investigated feasibility plasma and platelets ALK prediction inhibitor treatment outcomes.ALK-FISH...
Limited data are available on the mortality rates of patients receiving extracorporeal membrane oxygenation (ECMO) support for coronavirus disease 2019 (COVID-19). We aimed to analyze relationship between COVID-19 and clinical outcomes ECMO.
The thermal conduction characteristics of GeTe and Ge2Sb2Te5(GST) nanowires were investigated using an optical method to determine the local temperature by Raman spectroscopy. Since localization surface charge in a single-crystalline nanostructure can enhance charge-phonon scattering, conductivity value (κ) single crystalline GST was decreased significantly 1.44 Wm–1 K–1 for 1.13 GST, compared reported values polycrystalline structures. SET-to-RESET state are characteristic memory device....
The presence of human norovirus in the aquatic environment can cause outbreaks related to recreational activities and consumption norovirus-contaminated clams. In this study, we investigated prevalence genogroups I (GI) II (GII) coastal South Korea (March 2014 February 2015). A total 504 water samples were collected periodically from four areas (total sites = 63), which 44 estuaries (clam fisheries) 19 inflow streams. RT-PCR analysis targeting ORF2 region C revealed that 20.6% contaminated...
Objective Pneumocystis jirovecii pneumonia (PCP) is a fatal respiratory infection, mostly associated with immunocompromised conditions. Several reports have described PCP development in patients who were not immunocompromised, but the clinical course and prognosis of are well understood. We compared characteristics prognoses between without conditions developed PCP. Methods retrospectively analyzed had been treated for from three hospitals. defined (IC) status as following: human...
The guidelines for chronic obstructive pulmonary disease (COPD) treatment are important the management of disease. However, studies regarding adherence to Global Initiative Chronic Obstructive Lung Disease (GOLD) have been scarce in Korea. Therefore, examine GOLD guidelines, we examined patterns prescribed medication COPD patients from 2011 2018. Patients were classified as having appropriately and inappropriately treated (overtreatment or undertreatment) group. Appropriate medical therapy...
Abstract Background The concurrence of sarcoidosis and primary lung cancer is very rare. We report a rare case with delayed diagnosis due to its misdiagnosis as worsening pulmonary sarcoidosis. Case presentation A 68-year-old man presented the outpatient department for evaluation mass in right hilar area lymphadenopathies subcarinal both interlobar areas on chest computed tomography (CT). Sufficient core samples were obtained from bilateral lymph nodes using endobronchial ultrasonography...
This study aimed to evaluate hypersensitivity reactions anti-tuberculosis (TB) drugs.We retrospectively compared the clinical manifestations and treatment outcomes of single multiple drug (DHRs).Twenty-eight patients were diagnosed with anti-TB DHRs using oral provocation tests. Of these 28 patients, 17 (60.7%) had a 11 (39.3%) DHRs. The median age was 57.5 years (interquartile range [IQR], 39.2-73.2). total 18 (64.3%) men. number drugs causing 2.0 (IQR 2.0-3.0). Rifampin most common that...
Objective Mucosal-associated invariant T (MAIT) cells are a subset of innate-like that engaged in number diseases, but their roles acute respiratory distress syndrome (ARDS) not fully examined yet. This study aimed to examine levels and functions MAIT patients with ARDS. Methods Peripheral blood samples from ARDS (n=50) healthy controls (HCs, n=50) were collected. Levels cells, cytokines, CD69, programmed cell death-1 (PD-1) lymphocyte-activation gene 3 (LAG-3) measured by flow cytometry....
For applications of microorganisms as probiotics in the food industry, safety evaluation has increasingly become important to ensure health consumers. Although people have been using various lactic acid bacteria for different purposes, some studies reported that certain exhibit properties virulence and produce toxic compounds. Thus, it is necessary examine characteristics associated with are safe use probiotics. This research aimed assess
Mycosporine-like amino acids (MAAs) have been used in cosmetics and pharmaceuticals. The purpose of this work was to develop yeast strains for sustainable economical production MAAs, especially shinorine. First, genes involved MAA biosynthetic pathway from Actinosynnema mirum were introduced into Saccharomyces cerevisiae heterologous shinorine production. Second, combinatorial expression wild mutant xylose reductase adopted the engineered S. facilitate utilization pentose phosphate pathway....
Few studies have examined the risk factors associated with type of acute respiratory failure (ARF) in patients exacerbation chronic obstructive pulmonary disease (COPD). This study evaluated clinical characteristics and prognosis hospitalized for COPD based on ARF. The medical charts between 2016 2021 were retrospectively reviewed. We classified ARF into 2 types: 1 PaO2 < 60 mm Hg room air or a ratio arterial partial pressure to fractional inspired oxygen 300, PaCO2 > 45 pH 7.35. A total 435...
Acute respiratory distress syndrome (ARDS) presents a global health challenge, characterized by significant morbidity and mortality. However, the role of natural killer T (NKT) cells in human ARDS remains poorly understood. Therefore, this study explored numerical functional status NKT patients with ARDS, examining their clinical relevance interactions macrophages fibroblasts during various stages syndrome.
Background Pyrazinamide (PZA) usage has been associated with adverse drug reactions, prompting its avoidance in treating elderly tuberculosis (TB) patients. This study aims to examine whether the administration of PZA is poor outcomes during TB treatment among individuals. Methods A retrospective analysis was undertaken on data collected from a prospective cohort conducted between July 2019 and June 2023, which involved patients 18 institutions across Republic Korea. The aimed assess impact...
Background The sensitivity of interferon-gamma release assays (IGRAs) in the detection Mycobacterium tuberculosis infection could be affected by conditions immune dysregulation. For this reason, diabetes mellitus (DM) may increase frequency indeterminate results IGRAs. However, there have been inconsistent reports role DM on IGRA results. Methods We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital....
Temozolomide-Associated Bronchiolitis Obliterans Organizing Pneumonia Successfully Treated with High-Dose CorticosteroidTemozolomide is an oral alkylating agent clinical activity against glioblastoma multiforme (GM).It generally well-tolerated and has few pulmonary side effects.We report a case of temozolomide-associated brochiolitis obliterans organizing pneumonia (BOOP) requiring very high-dose corticosteroid treatment.A 56-yr-old woman presented 2-week history exertional dyspnea.For the...
: Chlorine-containing bleach can cause acute respiratory distress syndrome (ARDS) and chemical burns. However, simultaneous occurrence of the two conditions caused by this agent is very rare. We describe case a 74-year-old female who presented with shortness breath hemoptysis following accidental exposure to chlorine-containing bleach. She had second- third-degree burns on both buttocks thighs, received mechanical ventilation because development ARDS. Mechanical was discontinued day 6...
Abstract Rationale: Current guidelines for advanced non-small cell lung cancer (NSCLC) recommend the use of targeted agents specific driver genes after confirming genetic alterations. Although epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement are usually mutually exclusive, EGFR ALK co-alterations have been reported increasingly in cases NSCLC. However, optimal treatment these has not established. Patient concerns: This case series describes...
Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance peripheral blood in patients undergoing anti-TB treatment.We retrospectively reviewed laboratory data who received had (> 5% total white cell count) at Chonnam National University Hospital between January 2010 December 2014.Of all 2,234 with TB treatment, 397 (17.8%) eosinophilia. Of eosinophilia, we 262 (66%),...
Abstract Rationale: Influenza is an infection caused by the influenza virus, and its symptoms are mostly mild self-limiting. However, can cause severe or fatal complications in high-risk patients. Although tracheobronchitis one of common influenza, necrotizing very rare. Herein, we describe a case causing airway obstruction complicated pandemic 2009 H1N1 influenza. Patient concerns: A 60-year-old man presented with fever dyspnea. On arrival at emergency room (ER), patient received oxygen 4...
Hyperuricemia is common during tuberculosis (TB) treatment, especially in association with pyrazinamide (PZA). This study investigated the relationship between major adverse cardiovascular events (MACEs) and hyperuricemia TB treatment.We conducted a single-center retrospective cohort study. From January 2010 through June 2017, we assessed all consecutive patients at Chonnam National University Hospital South Korea. was defined as serum uric acid levels exceeding 7.0 mg/dL (men) 6.0...