A5054473800- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Insect Resistance and Genetics
- Pleural and Pulmonary Diseases
- Insect Utilization and Effects
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- Neurobiology and Insect Physiology Research
- Enzyme Production and Characterization
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Biofuel production and bioconversion
- Lipid metabolism and biosynthesis
- Cancer-related molecular mechanisms research
- Vascular Anomalies and Treatments
- Essential Oils and Antimicrobial Activity
- Trace Elements in Health
- Silkworms and Sericulture Research
- Lung Cancer Diagnosis and Treatment
- Silk-based biomaterials and applications
Kyungpook National University
2010-2024
Wonkwang University
2013-2022
Indiana University School of Medicine
2015
Roswell Park Comprehensive Cancer Center
2015
Jeonbuk National University
2001-2002
Korea University
1998
An ethanol extract of the stem Opuntia ficus-indica var. saboten (OFS) was assessed to determine mechanism(s) its antioxidant activity. The exhibited a concentration-dependent inhibition linoleic acid oxidation in thiocyanate assay system. In addition, OFS showed dose-dependent free-radical scavenging activity, including DPPH radicals, superoxide anions (O(2)(*-)), and hydroxyl radicals (*OH), using different systems. also found be effective protecting plasmid DNA against strand breakage...
Shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, induces necroptosis in various cancer types, but the mechanisms underlying anticancer activity of shikonin lung are not fully understood. This study was designed to clarify whether causes non-small cell (NSCLC) cells and investigate mechanism action.Multiplex caspase 8 assays were used analyze effect on A549 cells. Cytometry with annexin V/PI staining MTT mode death. Western blotting determine...
Relatively little is known about the efficacy and safety of programmatic use bedaquiline delamanid in multidrug-resistant tuberculosis (MDR-TB) treatment. This study evaluated 61 patients with MDR-TB treated (n=39), (n=11) or both, either sequentially (n=10) coadministration (n=1), for >1 month, combined a World Health Organization-recommended regimen. Of these, 49 (80.3%) were male 12 (19.7%) female. The median (interquartile range (IQR)) age was 53 (38.5–61.0) years. 42 (68.9%) had...
Salinomycin (Sal) is a recently identified anti-tumor drug for treating several types of solid tumor; however, its effects on the migratory and invasive properties non-small cell lung cancer (NSCLC) remain unclear.This study investigated inhibitory effect underlying mechanisms Salon transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) migration.Sal solidly blocked migration invasion enhancement by TGF-β1-induced EMT, through recovering E-cadherin loss...
Pemetrexed, a multitarget antifolate used to treat malignant mesothelioma and non-small cell lung cancer (NSCLC), has been shown stimulate autophagy. In this study, we determined whether autophagy could be induced by pemetrexed simvastatin cotreatment in NSCLC cells. Furthermore, inhibition of drives apoptosis Malignant MSTO-211H A549 cells were treated with alone combination evaluate their effect on apoptosis. Cotreatment greater caspase-dependent than either drug 3-Methyladenine (3-MA),...
Serine/arginine-rich splicing factors (SRSFs) and HNRNPA1 have oncogenic properties. However, their proteomic expressions practical priority in gastric cancer (GC) colorectal (CRC) are mostly unknown. To apply SFs clinics, effective marker selection characterization of properties the target organ essential. We concurrently analyzed SRSF1, 3, 5–7, HNRNPA1, together with conventional tumor carcinoembryonic antigen (CEA), stomach tissue samples (n = 420) using semiquantitative immunoblot,...
The non-steroidal anti-inflammatory drugs (NSAIDs) celecoxib and sulindac have been reported to suppress lung cancer migration invasion. class III deacetylase sirtuin 1 (SIRT1) possesses both pro- anticarcinogenic properties. However, its role in inhibition of cell epithelial-mesenchymal transition (EMT) by NSAIDs is not clearly known. We attempted investigate the potential use as inhibitors TGF-β1-induced EMT A549 cells, underlying mechanisms suppression invasion sulindac. demonstrated that...
YKL-40 is associated with various neurological disorders. However, circulatory levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness measuring serum immediately following AIS.Serum C-reactive protein (CRP) were monitored over time in AIS patients (n = 105) compared those stroke-free controls 34). Infarct volume severity (National Institutes Health Stroke Scale; NIHSS) measured within 48...
In this paper, a smartphone-based lung function test, developed to estimate parameters using high-resolution time-frequency spectrum from smartphone built-in microphone is presented. A method of estimation the forced expiratory volume in 1 s divided by vital capacity (FEV₁/FVC) based on variable frequency complex demodulation (VFCDM) first proposed. We evaluated our proposed 26 subjects, including 13 healthy subjects and chronic obstructive pulmonary disease (COPD) patients, comparing with...
Pemetrexed is a multitarget antifolate currently used for the treatment of malignant mesothelioma and non-small cell lung cancer (NSCLC). Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors primarily hyperlidpidemia, have been studied their antiproliferative pro-apoptotic effects. However, effects simvastatin on pemetrexed-induced apoptosis not investigated. In this study, we investigated whether combination with pemetrexed potentiates apoptotic activity above that...
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to enhance the responsiveness of tumor cells toward chemotherapeutic and radiation. However, precise mechanism synergistic enhancement in tumoricidal activity is not clearly known. Herein, we demonstrate that combination treatment arsenic trioxide (As2O3) sulindac resulted a augmentation cytotoxicity NCI-H157 lung cancer cells, which was revealed as apoptosis accompanied by chromatin fragmentation an increase sub-G0/G1 fraction. In...
Background/Aims Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated clinical and pleural fluid features pleuropulmonary masquerading as tuberculosis. Methods retrospectively analyzed characteristics 20 patients diagnosed with between 2001 2011. Results In total, 17 presented respiratory symptoms, including dyspnea (30%), hemoptysis (20%), cough pleuritic chest pain (15%). Chest radiographs revealed...
Objective Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), serine/arginine-rich splicing factor 1 (SRSF1), and SRSF3 are regulators associated with oncogenesis. However, the alterations of SF proteins their diagnostic values in cervical cancer unclear. To apply SFs clinically, effective marker selection characterization target organ properties essential. Materials Methods We concurrently analyzed HNRNPA1, SRSF1, SRSF3, conventional tumor markers squamous cell carcinoma antigen (SCCA)...