A5071975149- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
- Tuberculosis Research and Epidemiology
- Soft tissue tumor case studies
- Childhood Cancer Survivors' Quality of Life
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Myocardial Infarction Research
- Autophagy in Disease and Therapy
- Travel-related health issues
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Parasites and Host Interactions
- Cancer therapeutics and mechanisms
- Folate and B Vitamins Research
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Histone Deacetylase Inhibitors Research
- Parathyroid Disorders and Treatments
- Vascular Anomalies and Treatments
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Analytical Methods in Pharmaceuticals
- Peroxisome Proliferator-Activated Receptors
- Protein Degradation and Inhibitors
Samsung Medical Center
2019-2023
Sungkyunkwan University
2019-2023
Wonkwang University
1970-2021
Pemetrexed, a multitarget antifolate used to treat malignant mesothelioma and non-small cell lung cancer (NSCLC), has been shown stimulate autophagy. In this study, we determined whether autophagy could be induced by pemetrexed simvastatin cotreatment in NSCLC cells. Furthermore, inhibition of drives apoptosis Malignant MSTO-211H A549 cells were treated with alone combination evaluate their effect on apoptosis. Cotreatment greater caspase-dependent than either drug 3-Methyladenine (3-MA),...
Background/Aims Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated clinical and pleural fluid features pleuropulmonary masquerading as tuberculosis. Methods retrospectively analyzed characteristics 20 patients diagnosed with between 2001 2011. Results In total, 17 presented respiratory symptoms, including dyspnea (30%), hemoptysis (20%), cough pleuritic chest pain (15%). Chest radiographs revealed...
Systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) has recently been identified as an inflammatory marker. We aimed to evaluate the prognostic implications of preoperative SII in patients undergoing isolated tricuspid valve (TV) surgery. In total, 213 who underwent TV surgery between January 2000 and December 2018 were enrolled. They divided into two groups, follows: low (<455.6 109/L), high (≥455.6 109/L). The correlation clinical outcomes was analyzed via Cox...
First-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients with advanced non-small cell lung cancer who were selected on the basis of EGFR mutations have improved progression-free survival acceptable toxicity compared to standard chemotherapy. However, acquired resistance EGFR-TKIs has been identified as an important clinical problem. Transformation small (SCLC) is a rare mechanism EGFR-TKI therapy. We describe case 61-year-old man presented...
Interferon-Gamma Release Assays (IGRAs) are widely used in the laboratory diagnosis of Mycobacterium tuberculosis (MTB) infections, particularly latent form. We compared performance a newly developed IGRA, Standard E TB-Feron ELISA (TBF) with currently QuantiFERON-TB Gold Plus assay (QFT-Plus) for detection infections (LTBIs) tertiary care settings. also investigated interferon-gamma (IFN-γ) released by T cell subsets via intracellular cytokine staining (ICS) and flow cytometry. A total 335...
Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs in human non-small cell lung cancer cells has not been elucidated. In this study, we investigated synergistic interaction sulindac simvastatin A549 cells.Cell viability was measured an MTT assay, while expression apoptotic markers, AKT, response to examined Western blotting. DNA fragmentation apoptosis analyzed...
Malignant melanoma occurs most frequently on the skin. However, it can also arise in other organs and tissues of body. Primary pulmonary malignant is a very rare non-epithelial neoplasm accounting for 0.01% all primary tumors. The treatment choice surgical resection tumor with an oncologically adequate margin as lobectomy or pneumonectomy. prognosis this condition rather poor. Based previous data, its 5-year survival at least 10%. Here, we report case 82-year-old woman whose was detected...
Malignant fibrous histiocytoma (MFH), a type of sarcoma, is malignant neoplasm with uncertain origins that arise from both the soft tissues and bone. The occurrence MFH on chest wall extremely rare. We hereby report case 72-year-old woman who was incidentally detected after traffic accident.
We report an unusual case of obstructive pneumonia due to unknown eosinophilic mucoid impaction the bronchi (MIB). A 54-year-old woman visited our hospital for investigation abnormal shadows visible on a chest radiograph. Chest computed tomography and bronchoscopic examination revealed MIB. Histopathological biopsied mucosal tissue extensive infiltration. With exclusion medical diseases that can cause eosinophilia, was diagnosed. The eosinophilia remained unknown. resolved after oral steroid...
<b>Background:</b> Oleanolic acid acetate (OAA) is a triterpenoid compound derived from Vigna angularis and known to have various effects such as tumor suppression, kidney protection, anti-inflammatory effect. However, research on the inhibition mechanisms of OAA in fibrosis limited. In this study, we investigated bleomycin-induced pulmonary mice its underlying mechanism vivo vitro. <b>Methods:</b> The effect was evaluated by measuring histological changes, mRNA, BALF, collagen content...
Parathyroid carcinoma is a rare cancer, and the development under secondary hyperparathyroidism also clinically infrequent. The diagnosis of parathyroid may be difficult due to radiological similarity between adenoma. Moreover, if hemodiaytic patients only show hyperplasia without adenomatous change by uncontrolled hyperphosphatemia, maligant gland rarely developed. We report an interesting case showing ectopic mediastinal related with in patient end-stage renal disease (ESRD) undergoing...