A5100393583- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Advanced DC-DC Converters
- Multilevel Inverters and Converters
- Photovoltaic System Optimization Techniques
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Metastasis and carcinoma case studies
- Mycobacterium research and diagnosis
- Cancer Cells and Metastasis
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Colorectal and Anal Carcinomas
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Agaplesion Markus Hospital
2023
Goethe University Frankfurt
2023
Weatherford College
2022
Inje University Seoul Paik Hospital
2022
Yonsei University
2021
Korea University
2021
University of Ulsan
2016-2020
Asan Medical Center
2003-2020
Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases in developing countries. We have evaluated the incidence prevalence of CD UC over time a district Seoul, Korea.A population-based study was performed from 1986 to 2005 Songpa-Kangdong Seoul. To recruit patients as completely possible, multiple information sources, including all medical facilities area 3 referral centers nearby but outside area, were used.During 20-year period, 138 incident cases (102 men, 36 women)...
Although some studies have shown that the quantitative, immunochemical fecal occult blood test (FOBT) (qFIT) has better performance characteristics than standard guaiac-based FOBT (GT) for identifying advanced colorectal neoplasia (ACRN), there is limited information on of these tests in average-risk populations.Seven hundred seventy consecutive patients from four centers who were undergoing screening colonoscopy also provided stool samples. Stool specimens three bowel movements applied to a...
Although the incidence of inflammatory bowel disease [IBD] is increasing in Asia, data on long-term epidemiological trends are limited. We performed a 30-year longitudinal study to investigate temporal epidemiology Crohn's [CD] and ulcerative colitis [UC] Seoul, Korea.This population-based included 1431 IBD patients [418 CD, 1013 UC] diagnosed between 1986 2015 Songpa-Kangdong district Korea. Temporal incidence, prevalence, phenotype at diagnosis were analysed.The adjusted mean annual rates...
The QUASAR Phase 2b Induction Study evaluated the efficacy and safety of guselkumab, an interleukin-23p19 subunit antagonist, in patients with moderately to severely active ulcerative colitis (UC) prior inadequate response and/or intolerance corticosteroids, immunosuppressants, advanced therapy.
Beta-amyloid (betaA)-induced oxidative toxicity on neuronal cells is a principal route in Alzheimer's disease (AD), and its occurs after fibril formation. Inhibitory or promoting effects of naturally occurring compounds betaA formation were evaluated. Among 214 tested compounds, curcuminoids, flavone type flavonoids, naphthoquinones shown to be potent inhibitors fibrilization. The addition the curcumin, demethoxycurcumin, bisdemethoxycurcumin strongly inhibited Flavonoids such as quercetin,...
Abstract Background and Aim: Although increased mast cells in the gut their role visceral hypersensitivity irritable bowel syndrome have been postulated, this relationship remains unclear. Our aim was to determine whether a exists between number of mucosal hypersensitivity. Method: Eighteen patients with diarrhea predominant (D‐IBS) (eight females, 10 males aged 25–65 years; mean 42.6 years) symptoms meeting Rome‐II criteria, 15 healthy controls (five 31–57 41.4 were recruited. Participants...
<h3>Objective</h3> Crohn9s disease (CD) is an intractable inflammatory bowel (IBD) of unknown cause. Recent meta-analysis the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited other populations. <h3>Methods</h3> We performed a GWAS two validation Korean population comprising total 2311 patients with CD 2442 controls. <h3>Results</h3> confirmed four previously reported loci: <i>TNFSF15</i>,...
Abstract Background and Aims: Epidemiologic studies provide evidence for a link between obesity or diabetes the risk colorectal cancer. However, there is lack of information about relationship metabolic syndrome adenoma. Therefore, we investigated whether factor Methods: We did study consecutive subjects who underwent colonoscopy as screening exam at Center Health Promotion, Samsung Medical Center, from March 2004 to December 2005. According modified ATP III criteria, was diagnosed....
In this paper, a new control strategy for improving weighted efficiency in photovoltaic (PV) ac module-type interleaved flyback inverters (ILFIs) is proposed. The of the ILFI PV modules has to be high, not only maximum power, but also other power levels according weather conditions. For conversion improvement all load ranges, method an output module proposed paper. controls active clamp circuit and each converter phase module. Thus, as conditioner can improved range Theoretical analysis,...
Abstract Although colorectal cancer (CRC) is considered one of the most preventable cancers, no non-invasive, accurate diagnostic tool to screen CRC exists. We explored potential urine nuclear magnetic resonance (NMR) metabolomics as a for early detection CRC, focusing on advanced adenoma and stage 0 CRC. Urine profiles from patients with neoplasia (CRN; 36 adenomas 56 CRCs at various stages, n = 92) healthy controls (normal, 156) were analyzed by NMR spectroscopy. Healthy CRN groups...
Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen colonoscopy.A total 232 patients were randomly assigned receive 4 liters PEG (day before procedure; group 1, n=79), 2 procedure) followed by another 2, n=80), or citrate (250 ml, day 3, n=73). quality bowel cleansing, tolerability, adverse effects in 3 compared with those groups 1...
Abstract Background Colorectal carcinoma (CRC) with CpG island methylator phenotype (CIMP) is recognized as a distinct subgroup of CRC, and CIMP status affects prognosis response to chemotherapy. Identification in CRC important for proper patient management. In Eastern countries, however, the clinicopathologic molecular characteristics CRCs are still unclear. Methods A total 245 patients who underwent their first surgical resection sporadic were enrolled was determined using quantitative...
Although recent studies have reported that inflammatory bowel disease [IBD] is associated with the development of neurodegenerative diseases via chronic intestinal inflammation and gut-brain axis, there insufficient evidence supporting this notion. The aim study was to determine risk including Parkinson's [PD] Alzheimer's [AD] in patients IBD.Using National Health Insurance Service data for entire Korean population, we identified IBD controls from 2009 2011 followed them up until 2017. We...
In this paper, the auxiliary switch control using a lookup table is proposed to enhance efficiency of bidirectional dc/dc converter used in electric vehicle, which performs soft switching. Continuous current data are difficult obtain during resonant operation due limit DSP ADC capacity. The has reference turn-on time. method properly controls time according required load current; brings more efficient generative and regenerative mode operation. approach been validated by results experiments...
In this paper, a weighted-efficiency enhancement control method for an interleaved flyback inverter using synchronous rectifier is proposed based on photovoltaic ac modules. method, the operation of classified according to voltage spike across main switch. When switch lower than rating switch, active clamp circuit interrupted reduce switching loss auxiliary At time, operated zero-voltage higher activated spike. The conduction secondary output diode. Thus, can be reduced in low power region,...
The role of Helicobacter pylori (H. pylori) in the development colorectal neoplasm remains controversial. We examined association between H. infection and a large sample healthy participants who underwent screening colonoscopy.A cross-sectional study 8916 men, participated regular health-screening examination that included an pylori-specific immunoglobulin G antibody test colonoscopy, was conducted to evaluate neoplasm.Multivariable analyses adjusted for age, body mass index, smoking status,...
The prognosis of early-onset sporadic colorectal cancer (CRC) patients remains controversial. objective this study was to assess the long-term outcome and prognostic factors CRC in young patients. From 2006 2011, 8207 underwent curative or palliative surgery for CRCs our institution. A total 693 who were ≤45 years old with enrolled as group. 1823 aged between 56 65 identified middle-aged control group study. Survival compared two groups. Young had higher recurrence rate than older stages I...
Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with evaluate impact on clinical course a Korean CD patient cohort. We performed multicenter retrospective analysis 1,047 registered Disease Clinical Network Cohort study Korea. The mean interval was 16.0 ± 33.1 months. Multivariate showed that older age at diagnosis (≥40 years)...
Several recurrent mutations and epigenetic changes have been identified in advanced gastric cancer, but the genetic alterations associated with early carcinogenesis malignant transformation remain unclear. We investigated genomic transcriptomic landscape of adenomas low-grade dysplasia (LGD) high-grade (HGD), intestinal-type cancer (EGC). The results were validated an independent cohort that included EGCs directly adjacent to adenoma (EGC-adenomas) process transformation, de novo do not seem...
Abstract Aims NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2−/− CD1d−/− mice display structural functional alterations Paneth cells, animal studies have reported no impact or deficiency on experimental colitis. mutations increase the susceptibility to inflammatory bowel diseases bound α-galactosylceramide [α-GalCer] alleviates intestinal inflammation. We evaluated effect modulation colitis mice. Methods The augmentation...
Abstract Background Although the pharmacokinetic profile of subcutaneous (SC) infliximab (IFX) is superior to conventional intravenous (IV) IFX, long-term efficacy and safety SC IFX in patients with inflammatory bowel disease (IBD) have not been reported yet. This study aimed evaluate clinical outcomes IBD treated compared those IV during maintenance therapy. Methods prospective cohort enrolled 61 remission who received scheduled Of them, 38 were switched while 23 continued dose...