A5063312750- Transportation Planning and Optimization
- Engineering Applied Research
- Fusion materials and technologies
- Traffic Prediction and Management Techniques
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Odor and Emission Control Technologies
- Enzyme Catalysis and Immobilization
- Urban Transport and Accessibility
- Nuclear Physics and Applications
- Infrastructure Maintenance and Monitoring
- Transportation and Mobility Innovations
- biodegradable polymer synthesis and properties
- Color perception and design
- Structural Load-Bearing Analysis
- Nuclear Materials and Properties
- Wastewater Treatment and Nitrogen Removal
- Structural Behavior of Reinforced Concrete
- Traffic control and management
- Maritime Ports and Logistics
- Safety Warnings and Signage
- Vehicle emissions and performance
- Energy and Environmental Systems
- Aviation Industry Analysis and Trends
- Lignin and Wood Chemistry
Jeonbuk National University
2010-2023
National Institutes for Quantum Science and Technology
2018-2020
Kyung Hee University
2001-2017
Seoul National University
2004-2017
Seoul National University Hospital
2013
Korea Electric Power Corporation (South Korea)
2002-2012
LSIS (South Korea)
2005
Korea Advanced Institute of Science and Technology
1997
University of Minnesota
1992-1995
Purdue University West Lafayette
1989-1991
<h3>Objective</h3> Genome wide association studies (GWAS) and meta-analyses for Crohn9s disease (CD) have not fully explained the heritability of CD, suggesting that additional loci are yet to be found known may contain high effect rare risk variants thus far gone undetected by GWAS. While cost deep sequencing remains too analyse many samples, targeted pooled DNA samples allows efficient effective capture all variations in a target region. <h3>Design</h3> We performed 500 Korean CD cases...
Because of the development scientific technology, drivers now have access to a variety information assist their decision making. In particular, an accurate prediction travel time is valuable drivers, who can use it choose route or decide on departure time. Although many researchers sought enhance accuracy, such predictions are often limited by errors that result from lagged pattern predicted time, nonrepresentative samples for making predictions, and inefficient nontransferable models. The...
Musical abilities such as recognising music and singing performance serve means for communication are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these rarely extended discovery genes molecules associated with ability.A total 1008 individuals from 73 families were enrolled a pitch-production accuracy test was applied determine ability. To identify genetic loci variants that contribute ability, we conducted...
Significance Gastric cancer (GC) is one of the major causes cancer-related deaths worldwide, but targeted therapy for GC limited. Here, we identified two druggable targets from genomic alteration profiling 103 patients with Asia and validated target suitability using patient-derived xenograft models, which recapitulate tumor biology observed in patients. Combination irinotecan (standard treatment) a BCL2L1 ( BCL2 -like 1)-targeted drug was effective size reduction tumors having amplification...
Several recurrent mutations and epigenetic changes have been identified in advanced gastric cancer, but the genetic alterations associated with early carcinogenesis malignant transformation remain unclear. We investigated genomic transcriptomic landscape of adenomas low-grade dysplasia (LGD) high-grade (HGD), intestinal-type cancer (EGC). The results were validated an independent cohort that included EGCs directly adjacent to adenoma (EGC-adenomas) process transformation, de novo do not seem...
Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because its poor prognosis and limited information. To gain comprehensive view the alterations in GS to understand molecular etiology GS, we applied whole-exome sequencing analyses for 28 cases (6 blood-matched fresh-frozen tissues discovery set, 22 formalin-fixed paraffin-embedded validation set) copy-number variation microarrays 5 tissues. TP53 mutations were more prevalent (20/28, 70%)...
Most commercial epoxy resins have been produced using toxic bisphenol A. Lignin can be utilized as green substitute for A to produce bio-epoxy resins. Methanol-soluble kraft lignin was extracted by methanol fractionation epoxidation, and epoxidized into lignin-derived resin via two-step epoxidation consisting of epichlorohydrin addition epoxide ring restructuring. Epoxidized selectively separated from non- or less-reacted based on their solubility differences in organic solvents. The...
Abstract Simultaneous separation of solvent products during fermentation reduces product inhibition and increases reactor productivity. Separation techniques used for simultaneous extraction ethanol butanol-acetone are reviewed. These can be classified by removal into gas phase (vacuum fermentation, stripping), liquid (liquid-liquid extraction, aqueous two-phase system), solid (adsorption). Recent developments in use membranes. Membrane remove (pervaporation) (perstraction) using either or...
Methanol-insoluble high-molecular weight (Mw = 26,610 g mol−1) soft wood kraft lignin was oxypropylated under the mild condition of 40°C and 1 atm for 12 h in presence NaOH catalyst production bio-polyester. Fourier transform infrared spectra showed that polyether chains were extended due to oxypropylation reaction. The Mw Mn 46,330 17,110 mol−1, respectively. reacted with sebacic acid or polybutadiene (dicarboxy terminated) bio-polyester synthesis. While decomposition temperatures 217°C...
Abstract A new in situ product separation technique using gas stripping was applied to acetone‐butanol‐ethanol (ABE) fermentation a gas‐phase‐continuous immobilized cell trickle bed reactor. Both numerical and experimental studies showed that glucose conversion could be improved when the inhibitory compounds were stripped by gas. Solvents preferentially from broth, butanol removal as efficient acetone spite of butanol's high boiling point (117°C) because volatility at concentrations. Since...
Acetone-butanol-ethanol (ABE) fermentation was successfully carried out in an immobilized cell trickle bed reactor. The reactor composed of two serial columns packed with Clostridium acetobutylicum ATCC 824 entrapped on the surface natural sponge segments at a loading range 2.03-5.56 g dry cells/g sponge. average 3.58 Batch experiments indicated that critical pH above 4.2 is necessary for initiation growth. One media used during continuous consisted salt mixture alone and other nutrient...
Behçet's disease (BD) is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent uveitis, oral and genital ulcers skin lesions. To identify some pathogenic variants associated with severe we used targeted massively parallel sequencing methods to explore the genetic diversity of target regions. A solution-based enrichment kit was designed capture whole-exonic regions 132 candidate genes. Using multiplexing strategy, 32 samples from patients type uveitis...
Abstract Background and Aim Considering the significant racial ethnic diversity in genetic variation, it is unclear whether genome‐wide association studies‐identified colorectal cancer ( CRC )‐susceptibility single‐nucleotide polymorphisms SNP s) discovered European populations are also relevant to K orean population. However, studies on ‐susceptibility s oreans limited. Methods To investigate of variants, we genotyped for established E uropean 198 cases 329 controls orea. identify novel...