A5100458117- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- RNA Interference and Gene Delivery
- Pediatric Urology and Nephrology Studies
- Urinary and Genital Oncology Studies
- Virus-based gene therapy research
- Pleural and Pulmonary Diseases
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Radiation Dose and Imaging
- Spine and Intervertebral Disc Pathology
- PI3K/AKT/mTOR signaling in cancer
- Urologic and reproductive health conditions
- Trauma Management and Diagnosis
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Ureteral procedures and complications
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Ocular Surface and Contact Lens
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
Gachon University
2018-2025
University of Ulsan
2012-2025
Gangneung Asan Hospital
2011-2025
Ulsan College
2012-2025
Chonnam National University
2021-2024
Korea Polar Research Institute
2008-2024
Samsung Medical Center
2015-2024
Sungkyunkwan University
2024
Inje University Haeundae Paik Hospital
2023
Boramae Medical Center
2023
To compare the outcomes of open pyeloplasty (OP), laparoscopy-assisted extracorporeal (LEXP), and robotic-assisted laparoscopic (RALP) for ureteropelvic junction obstruction in pediatric patients.We retrospectively reviewed age-matched cohort 30 children who underwent OP, LEXP, 10 RALP at a single institution, from 1996 to 2014. Pre- post-operative variables including success rate were compared among surgical groups.The mean age patients was 120.2 months, Society Fetal Urology grade 3.6,...
The global increase in antibiotic consumption is related to increased adverse effects, such as antibiotic-associated diarrhea (AAD). This study investigated the chemical properties of Zingiber officinale Rosc (ZO) extract and its ameliorative effects using a lincomycin-induced AAD mouse model. Intestinal tissues were evaluated for expression lysozyme, claudin-1, α-defensin-1, which are associated with intestinal homeostasis. cecum was analyzed assess concentration short-chain fatty acids...
Dof proteins are transcription factors that have a conserved single zinc finger DNA-binding domain. In this study, we isolated an activation tagging mutant Dof5.1-D exhibiting upward-curling leaf phenotype due to enhanced expression of the REV gene is required for establishing adaxial–abaxial polarity. plants also had reduced transcript levels IAA6 and IAA19 genes, indicating altered auxin biosynthesis in Dof5.1-D. An electrophoretic mobility shift assay using Dof5.1 motif promoter region...
Several recurrent mutations and epigenetic changes have been identified in advanced gastric cancer, but the genetic alterations associated with early carcinogenesis malignant transformation remain unclear. We investigated genomic transcriptomic landscape of adenomas low-grade dysplasia (LGD) high-grade (HGD), intestinal-type cancer (EGC). The results were validated an independent cohort that included EGCs directly adjacent to adenoma (EGC-adenomas) process transformation, de novo do not seem...
Background: Ice plant (Mesembryanthemum crystallinum) is a vegetable with various therapeutic uses, one of which its ability to prevent diabetes. The present study examined the insulin secretion effect related mechanism action ice extract (IPE) and active compound D-pinitol in rat insulin-secreting β-cell line, INS-1, as well diabetic rats. Methods: glucose-stimulated (GSIS) test Western blotting were used measure GSIS. index (GSI) expression levels insulin-related pathway factors, including...
This study introduces a deep learning-based strategy to automatically detect the L3 slice and segment abdominal tissues from computed tomography (CT) images. Accurate measurement of muscle fat composition at level is critical as it can serve prognostic biomarker for cancer diagnosis treatment. However, current manual approaches are time-consuming prone class imbalance, since slices constitute only small fraction entire CT dataset. In this study, we propose an optimization-incorporated that...
Protein–protein interaction (PPI) extraction has been an important research topic in bio-text mining area, since the PPI information is critical for understanding biological processes. However, there are very few open systems available on Web and most of focus keyword searching based predefined PPIs. PIE (Protein Interaction Extraction system) a configurable service to extract PPIs from literature, including user-provided papers as well PubMed articles. After providing abstracts or papers,...
The oncogenic BRAF(V600E) mutation results in an active structural conformation characterized by greatly elevated ERK activity. However, additional cellular effects caused subcellular action of remain to be identified.To explore these effects, differences the localization wild-type and mutant BRAF thyroid cancer were investigated.A significant proportion endogenous exogenous BRAF(V600E), but not BRAF, was detected mitochondrial fraction, similar other mutants including BRAF(V600D),...
Introduction: Although both patients with kidney failure (KF) receiving hemodialysis (HD) and transplant (KT) recipients (KTRs) have a high risk of bladder cancer, how this changes in the transition from dialysis to KT is unknown. In study, we aimed investigate cancer KTRs on HD. Methods: This was nationwide longitudinal cohort study 66,547 participants National Health Insurance Service who started HD for KF or received 2002 2020. The primary outcome diagnosis which defined as composite...
Background The BRAFV600E mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator MST1 tumor suppressor pathways, inactivated by hypermethylation its promoter region in 20 32% PTC. However, PTC without RASSF1A methylation, the regulatory mechanisms RASSF1A-MST1 remain be elucidated, and functional cooperation or cross regulation between MST1,which activates Foxo3,has not...
DA-1229 is a novel, potent and selective dipeptidyl peptidase-4 (DPP-IV) inhibitor that orally bioavailable. We aimed to evaluate the optimal dose, efficacy safety of DA-1229, in Korean subjects with type 2 diabetes mellitus suboptimally controlled diet exercise.We enrolled 158 patients (mean age, 53 years mean BMI, 25.6 kg/m(2) ). The baseline fasting plasma glucose level, HbA1c duration were 8.28 mmol/L, 7.6% (60 mmol/mol) 3.9 years, respectively. After or 6 weeks an exercise program...
Deschampsia antarctica is a Poaceae grass that has adapted to and colonized Antarctica. When D. plants were subjected cold dehydration stress both in the Antarctic field laboratory experiments, galactinol, precursor of raffinose family oligosaccharides (RFOs) highly accumulated, which was accompanied by upregulation galactinol synthase (GolS). The monocots have small GolS genes, are divided into two distinct groups called types I II. Type II GolSs expanded cold-adapted monocot plants....
We undertook this study to evaluate the normal values of artery-bronchus ratio (ABR) and bronchial lumen (BLR) at subsegmental levels determine whether these can be used as objective parameters for evaluation various diseases involving bronchovascular trees.We analyzed high-resolution CT 30 patients without cardiopulmonary diseases. The studies were performed with 5 mm collimation intervals from carina level inferior pulmonary vein 1.5 10 through remainder lung. Both ABR, defined outer...
Background Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved the development and persistency pain symptoms. We thus hypothesize neuropathic may be attenuated by down-regulation GCH1 expression, propose a gene silencing system for this purpose. Results To interrupt synthesis, we designed bidirectional recombinant adeno-associated virus encoding both small hairpin RNA against GFP reporter (rAAV-shGCH1)....
Adenosine 5'-monophosphate (AMP) activated protein kinase (AMPK) has emerged as an attractive target molecule for the treatment of metabolic disorders, including obesity and type 2 diabetes. In this study, we identified a novel small molecule, ampkinone (6f), indirect AMPK activator, which was derived from library constructed by diversity-oriented synthesis. Ampkinone stimulated phosphorylation via activation in various cell lines. Ampkinone-mediated required activity LKB1 resulted increased...
The nuclear factor κB (NF-κB) and interleukin-6 (IL-6) contribute to multidrug resistance (MDR) in tumor chemotherapy. essential phenomenon of oncogenic activation NF-κB cancer-initiating cells showing MDR resulting from increased IL-6 expression is still unclear. Cancer stem (CSCs) have been the objective intensive study. aim this study was investigate selective potential efficacy BRM270 against stem-like (SLCICs) via molecular mechanisms its anticancer effects. Co-regulation Cdk6 might be...
Tumor initiating cancer stem-like cells (TICSCs) have recently become the object of intensive study. Human-Lipocalin-2 (hLCN2) acts as a biomarker for cancers. The aim present study was to explore new insights regarding potential role LCN2 in inducing epithelial mesenchymal transition (EMT) by transfecting into CD133+-A549-TICSCs and its cross-talk with NF-κB signaling pathway adenocarcinoma lung. Furthermore, EMT confirmed transcriptomic analysis, immunoblotting immunocyto/histochemical...
Qualitative analysis of cucurbitane-type triterpenoids bitter melon (fruit Momordica charantia L.) using ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry revealed 27 promising triterpenoids, and LC/MS-guided chemical M. fruit extract led to the isolation structural characterization 22 (1–22), including 8 new triterpenoidal saponins, yeojoosides A–H (1–8). The structures compounds (1–8) were elucidated by spectroscopic methods, 1D 2D NMR high-resolution...
Background and Objectives: Obesity has reached epidemic proportions globally affects people of all ages.Recent studies have shown that visceral adipose tissue measured by magnetic resonance imaging and/or computed tomography correlates positively with epicardial tissue.Epicardial fat, which is correlated to several metabolic parameters, can be assessed echocardiography.The aim this study was evaluate fat thickness other parameters in obese adolescents investigate the correlation between...
Plants respond to root temperature stresses by producing antioxidants as a defense mechanism. Since number of these are phytochemicals with enhancing effects on human health, we examined the 4 root-zone (RZT) treatments (10, 20, 28, and 36 °C) plant growth main bioactive compound concentrations in each organ Agastache rugosa plants. We aimed determine optimal RZT treatment increase no deleterious growth. Four-week-old seedlings were grown factory for 32 days. Nine parameters, namely, shoot...