A5100417338- Bone Tissue Engineering Materials
- Tuberculosis Research and Epidemiology
- Peripheral Neuropathies and Disorders
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Multiple Sclerosis Research Studies
- Acute Myeloid Leukemia Research
- Infectious Diseases and Mycology
- Food Quality and Safety Studies
- Plant Virus Research Studies
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Genomics and Rare Diseases
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Genetic Syndromes and Imprinting
- Dental Implant Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
Samsung Medical Center
2019-2025
Sungkyunkwan University
2019-2025
University of Pennsylvania
2022-2024
Gyeongsangnam-do Agricultural Research and Extension Services
2024
Seoul National University Hospital
2004-2024
Chungnam National University
2018-2024
Korea Research Institute of Standards and Science
2024
National Institute of Biological Resources
2021-2024
Mount Sinai Hospital
2024
University of California, Los Angeles
2023
Key clinical features of chronic relapsing inflammatory optic neuropathy (CRION) include neuritis (ON) and steroid dependency, both which have been reported among patients with myelin oligodendrocyte glycoprotein antibodies (MOG-Abs). We investigated the relevance presence serum MOG-IgG current diagnostic criteria for CRION idiopathic (iON).Retrospective reviews a database prospectively collated between 2011 2017 from tertiary referral center multiple sclerosis neuromyelitis optica were...
Glioblastoma (GBM) is a highly malignant human brain tumor with limited treatment choices. The extremely aggressive characteristics of GBM result from stem cells (GSCs), subpopulation in having self-renewal potential and resistance to chemotherapy radiotherapy. Therefore, eliminating GSCs an effective strategy treat this fatal disease. In study, we investigated the therapeutic effects dietary flavonoids, including apigenin, quercetin, naringenin, against cancer cell-like phenotypes cell...
Positive results from real-time reverse-transcription polymerase chain reaction (rRT-PCR) in recovered patients raise concern that who recover coronavirus disease 2019 (COVID-19) may be at risk of reinfection. Currently, however, evidence supports reinfection with severe acute respiratory syndrome 2 (SARS-CoV-2) has not been reported.We conducted whole-genome sequencing the viral RNA clinical specimens initial infection and positive retest 6 COVID-19 retested for SARS-CoV-2 via rRT-PCR after...
Abstract The major suppressive immune cells in tumor sites are myeloid derived suppressor (MDSCs), tumor‐associated macrophages (TAMs), and Treg cells, the roles of these include hindering T‐cell activities supporting progression survival. In this study, we analyzed pattern circulating MDSC subtypes patients with non‐small cell lung cancer (NSCLC) whether those hinder leading to poor clinical outcomes. First, verified PMN‐MDSCs, monocytic‐MDSCs (M‐MDSCs), increased according stages NSCLC,...
To investigate the clinical relevance of CSF myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) testing in a large multicenter cohort.
Aims Nocturnal acid breakthrough has been considered an unmet need of proton‐pump inhibitors. Tegoprazan, a novel potassium‐competitive blocker, is expected to show improved properties for this need. This study was aimed compare night‐time suppression by tegoprazan with that vonoprazan or esomeprazole, and explore the effect CYP2C19 phenotypes on acid‐suppressive effects. Methods A randomized, open‐label, 3‐period, 6‐sequence crossover conducted. single oral dose 50 mg, 20 mg esomeprazole 40...
Dipeptidyl peptidase IV (DPP-IV), a new target for the treatment of type 2 diabetes mellitus, degrades incretins such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide. DPP-IV inhibitors shorten inactivation GLP-1, permitting incretin to stimulate insulin release, thereby combating hyperglycemia. In our ongoing search from medicinal plants foods, three flavonol glycosides (1⁻3) were isolated seeds Lens culinaris Medikus (Fabaceae) tested their...
Abstract Background Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) that play an important role in cancer progression. Although mechanism by which CAFs promote tumorigenesis has been well investigated, underlying activation neighboring cells remains elusive. In this study, we aim to investigate signaling pathways involved gastric (GC) and provide insights into therapeutic targeting for overcoming GC. Methods Alteration receptor tyrosine kinase...
Musical abilities such as recognising music and singing performance serve means for communication are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these rarely extended discovery genes molecules associated with ability.A total 1008 individuals from 73 families were enrolled a pitch-production accuracy test was applied determine ability. To identify genetic loci variants that contribute ability, we conducted...
An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions natural bone. Many researchers have worked on fabrication different scaffold systems including ceramic–polymer hybrid system. In present study, we incorporated hyaluronic acid–gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier improve cell attachment proliferation through highly interconnected porous structure. This system is composed...
Pueraria lobata leaves contain a variety of phytoestrogens, including flavonoids, isoflavonoids, and coumestan derivatives. In this study, we aimed to identify the active ingredients P. elucidate their function in monoamine oxidase (MAO) activation Aβ self-aggregation using vitro silico approaches. To best our knowledge, is first study coumestrol as selective competitive MAO-A inhibitor. We identified that coumestrol, coumestan-derivative, exhibited inhibitory effect against (IC50 = 1.99 ±...
Importance A proportion of people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have a relapsing course and persistent anti–myelin immunoglobulin G (MOG-IgG) seropositivity. Few studies investigated whether treatment the first MOGAD attack is associated long-term and/or MOG-IgG seronegative conversion. Objective To investigate association time to treat acute relapse risk serostatus. Design, Setting, Participants This was retrospective, nationwide, multicenter...
Abstract Objectives Despite its utility, interpreting multiparameter flow cytometry (MFC) data for hematologic malignancy remains time-intensive and complex. This study evaluated the applicability of two dimensionality reduction (DR) algorithms, t-distributed stochastic neighbor embedding (t-SNE) uniform manifold approximation projection (UMAP), to MFC malignancy. Methods A total 237 samples were re-analyzed by t-SNE- UMAP-based gating: 80 with acute leukemia orientation tube panel, 42...
Background Accurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, production serum cystatin C has been extensively reported be unaffected by body muscle mass, age, gender, nutritional status. Methods Our study included 37 samples from diabetic chronic disease (CKD) patients for whom creatinine tests had requested 40 a healthy populations Dong-A University Hospital between May 2010 June 2010. The assay precision (i.e.,...
Flicker noise is the most crucial issue in an instrumentation amplifier (IA) for neural recordings because low-frequency signals overlap with frequency of amplifier's flicker noise. A Chopping technique, often used to reduce noise, not desirable high-impedance input sources due charge injection and clock feedthrough from MOSFETs chopper signal source, resulting a significant increase total input-referred Whereas have less at moment turning on, intrinsic can be then reduced by on off IA. This...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern have been emerging. However, knowledge temporal and spatial dynamics SARS-CoV-2 is limited. This study characterized evolution in immunosuppressed patients with long-term shedding for 73–250 days, without specific treatment. We conducted whole-genome sequencing 27 serial samples, including 26 samples collected from various anatomic sites two the first positive sample patient 2's mother. analysed intrahost...