A5026978255- Acute Myeloid Leukemia Research
- Prenatal Screening and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Hematopoietic Stem Cell Transplantation
- Blood groups and transfusion
- Marine Sponges and Natural Products
- Genomic variations and chromosomal abnormalities
- Sphingolipid Metabolism and Signaling
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Hemoglobinopathies and Related Disorders
- Coronary Interventions and Diagnostics
- Iron Metabolism and Disorders
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Synthetic Organic Chemistry Methods
- Clinical Laboratory Practices and Quality Control
- Venous Thromboembolism Diagnosis and Management
- Chromosomal and Genetic Variations
- Hematological disorders and diagnostics
- Peroxisome Proliferator-Activated Receptors
- Erythrocyte Function and Pathophysiology
Yonsei University
2025
Dong-A University
2015-2024
Dong-A University Hospital
2008-2023
Keimyung University
2004-2021
Seoul National University Bundang Hospital
2020
Sungkyunkwan University
2002-2020
Berry Oncology (China)
2020
Guangzhou Women and Children Medical Center
2019
Second Affiliated Hospital of Xi'an Jiaotong University
2018
Baylor College of Medicine
1994-2017
The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis to malignancy. Because C-reactive protein (CRP) a representative marker for inflammation, CRP has recently been associated with progression disease in many cancer types. principal objective this study was determine preoperative serum levels IL-6 gastric carcinoma, correlate them status prognosis. A total 115 patients who underwent gastrectomy were enrolled study. Serum assessed via Enzyme-Linked...
Angiogenesis is a multistep process in which many growth factors and cytokines have an essential role. Vascular endothelial factor (VEGF) potent angiogenic agent that acts as specific mitogen for vascular cells through cell surface receptors. The interleukin-6 (IL-6) pathway another mechanism linking angiogenesis to malignancy. C-reactive protein (CRP), representative marker inflammation, known its association with disease progression cancer types. aim of this study was determine...
Recent studies have shown that 15-deoxy-Delta(12, 14)-prostaglandin J(2) (15d-PGJ(2)), a natural ligand for peroxisome proliferator-activated receptor-gamma (PPARgamma), inhibits cell proliferation and induces apoptosis. The specific molecular mechanisms underlying this effect remain to be elucidated. We examined whether 15d-PGJ(2) has antitumor activity in vitro vivo, investigated the mechanism.We 15d-PGJ(2)-induced apoptosis human leukemia cells context of mitochondrial injury, oxidative...
Kyeong-Hee Kim, M.D., Kyung-Eun Kwang-Sook Woo, Jin-Yeong Han, Jeong-Man and Kyoung Un Park, M.D.. Korean J Lab Med 2009;29:361-5. https://doi.org/10.3343/kjlm.2009.29.4.361
Abstract Background Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, vascular endothelial (VEGF) are all important factors in the mechanisms inherent to progression. In this work, we have investigated clinicopathologic significance of HIF-1α, VEGF expression preoperative serum (sVEGF) level gastric cancer. We immunohistochemically assessed patterns 114 specimens Additionally, determined levels (sVEGF). Results The...
Contrary to many reports that antiplatelet agents inhibit cancer growth and metastasis, new solid tumors have been reported in patients receiving long-term therapy. We investigated the effects of these directly on cells absence platelets mimic When four (aspirin, clopidogrel, prasugrel, ticagrelor) were administered colon cells, cell proliferation was inhibited similarly a previous study. However, surprisingly, when treated with purinergic P2Y12 inhibitor (purinergic agent), motility...
Colorectal cancer (CRC) is a major cause of cancer-related mortality, highlighting the need for accurate and non-invasive diagnostics. This study assessed utility tumor-associated circulating transcripts (TACTs) as biomarkers CRC detection integrated these markers into machine learning models to enhance diagnostic performance. We evaluated five models-Generalized Linear Model, Random Forest, Gradient Boosting Machine, Deep Neural Network (DNN), AutoML-and identified DNN model optimal owing...
The principal objective of this study was to determine the relationship between preoperative coagulation tests and extent tumor involvement in gastric cancer patients.A total 110 patients with adenocarcinoma stomach were studied order evaluate relationship. Platelet count (P), prothrombin time (PT), activated partial thromboplastin time, D-dimer, fibrinogen degradation product, thrombin-antithrombin complex fragment F1+2 (F1+2) evaluated.The D-dimer levels positively correlated depth...
Marine triterpene glycosides that are physiologically active natural compounds isolated from sea cucumbers (holothurians) and sponges have antifungal, cytotoxic, antitumor activities, whose specific molecular mechanisms remain to be elucidated. In this study, we examined if through which stichoposide C (STC) Thelenota anax (family Stichopodidae) induces apoptosis in leukemia colorectal cancer cells.We STC-induced human cells the context of mitochondrial injury signaling pathway disturbances,...
Abstract Introduction Neutrophil extracellular traps (NETs) are known to be induced by various factors. In this study, we tried identify circulating levels of NETs in patients with acute coronary syndrome (ACS) and ischemic stroke (AIS) confirm its suitability as a new marker their detection. Methods We prospectively enrolled 95 diagnosis ACS (N = 37) or AIS 58) Dong‐A University Hospital, Busan, Korea. The control group was selected from healthy adults 25) who visited the hospital for...
This study shows whether increased intracellular cAMP level by cilostazol is directly coupled to its maxi-K channel activation in human endothelial cells. Cilostazol (1 μM) the K<sup>+</sup> currents cells activating channels, which was abolished iberiotoxin (100 nM), a blocker. On incubation of coronary artery with tumor necrosis factor-α (TNF-α) (50 ng/ml), monocyte adhesion significantly superoxide generation and expression vascular cell molecule-1 (VCAM-1) chemoattractant protein-1...
Background Accurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, production serum cystatin C has been extensively reported be unaffected by body muscle mass, age, gender, nutritional status. Methods Our study included 37 samples from diabetic chronic disease (CKD) patients for whom creatinine tests had requested 40 a healthy populations Dong-A University Hospital between May 2010 June 2010. The assay precision (i.e.,...
Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of acute kidney injury. There growing body evidence suggesting that NGAL also marker disease and severity in chronic (CKD). We studied the utility urinary more accurately predicting renal function patients with diabetic CKD.We possible relationships between NGAL, estimated glomerular filtration rate (eGFR), proteinuria CKD healthy populations.Urinary levels were significantly higher than controls (96.0 [2.7 to 975.2]...
Background It is still not easy to predict severity promptly in patients with acute ischemic stroke (AIS) and transient attack (TIA). We investigated that platelet parameters or combinations of them could be a useful tool for early prediction AIS TIA at admission after 3 months. Methods prospectively recruited 104 newly diagnosed TIA. their neutrophil‐to‐lymphocyte ratio (NLR) parameters. According the Modified Rankin Scale scores, were divided into two groups. Results In receiver operating...
Kyeong-Hee Kim, M.D., Sung-Won Lee, Won-Tae Chung, Byoung-Gwon Kwang-Sook Woo, Jin-Yeong Han, and Jeong-Man M.D.. Korean J Lab Med 2011;31:271-8. https://doi.org/10.3343/kjlm.2011.31.4.271