A5008918613- Marine Sponges and Natural Products
- Sphingolipid Metabolism and Signaling
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Bioactive Compounds and Antitumor Agents
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Synthetic Organic Chemistry Methods
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Virus-based gene therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Echinoderm biology and ecology
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Congenital Anomalies and Fetal Surgery
- Bacteriophages and microbial interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Retinoids in leukemia and cellular processes
- Adenosine and Purinergic Signaling
Sungkyunkwan University
2020-2024
Kangbuk Samsung Hospital
2020-2024
Seoul National University
2024
Dong-A University
2008-2023
RELX Group (Netherlands)
2012
Busan Medical Center
2012
Dong-A University Hospital
2012
Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences
2012
Institute of Bioorganic Chemistry
2012
Wonkwang University
2012
Recent studies have shown that 15-deoxy-Delta(12, 14)-prostaglandin J(2) (15d-PGJ(2)), a natural ligand for peroxisome proliferator-activated receptor-gamma (PPARgamma), inhibits cell proliferation and induces apoptosis. The specific molecular mechanisms underlying this effect remain to be elucidated. We examined whether 15d-PGJ(2) has antitumor activity in vitro vivo, investigated the mechanism.We 15d-PGJ(2)-induced apoptosis human leukemia cells context of mitochondrial injury, oxidative...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by fat accumulation in the liver. MASLD encompasses both steatosis and MASH. Since MASH can lead to cirrhosis cancer, must be distinguished during patient treatment. Here, we investigate genomes, epigenomes, transcriptomes of patients identify signature gene set for more accurate tracking progression.
Abstract Background Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, vascular endothelial (VEGF) are all important factors in the mechanisms inherent to progression. In this work, we have investigated clinicopathologic significance of HIF-1α, VEGF expression preoperative serum (sVEGF) level gastric cancer. We immunohistochemically assessed patterns 114 specimens Additionally, determined levels (sVEGF). Results The...
Marine triterpene glycosides that are physiologically active natural compounds isolated from sea cucumbers (holothurians) and sponges have antifungal, cytotoxic, antitumor activities, whose specific molecular mechanisms remain to be elucidated. In this study, we examined if through which stichoposide C (STC) Thelenota anax (family Stichopodidae) induces apoptosis in leukemia colorectal cancer cells.We STC-induced human cells the context of mitochondrial injury signaling pathway disturbances,...
PURPOSE: To identify the genes involved in carcinogenesis and progression of colorectal cancer, we analyzed gene-expression profiles cancer cells from 12 tumors with corresponding noncancerous colonic epithelia using a cDNA microarray representing 4,08 genes. METHODS: We classified both samples by twoway clustering analysis identified that were differentially expressed cancerous tissues. Genes associated lymph node metastasis means supervised learning technique. RESULTS: Differentially (77...
Abstract Purpose: Our previous studies suggested that human telomerase reverse transcriptase (hTERT) RNA-targeting trans-splicing ribozyme could be a useful tool for cancer gene therapy. Here, we investigated whether adenoviruses harboring this can systemically delivered to mice, and they selectively mark tumors expressing hTERT sensitize them ganciclovir treatments. Experimental Design: We constructed adenoviral vectors containing modified hTERT-targeting with downstream reporter...
We have developed and validated a new tumor-targeting gene therapy strategy based upon the targeting replacement of human telomerase reverse transcriptase (hTERT) RNA, using trans-splicing ribozyme. By constructing novel adenoviral vectors harboring hTERT-targeting ribozymes with downstream reporter (Ad-Ribo-LacZ) or suicide (Ad-Ribo-HSVtk) driven by cytomegalovirus (CMV) promoter, we demonstrated that this viral system selectively marks tumor cells expressing hTERT sensitizes to prodrug...
Abstract Hepatocellular carcinoma (HCC) has a high fatality rate and limited therapeutic options with side effects low efficacy. Here, we proposed new anti-HCC approach based on cancer-specific post-transcriptional targeting. To this end, trans -splicing ribozymes from Tetrahymena group I intron were developed, which can specifically induce gene activity through HCC-specific replacement of telomerase reverse transcriptase (TERT) RNA. circumvent due to TERT expression in regenerating liver...
Long working hours are known to account for approximately one-third of the total expected work-related diseases, and much interest research on long have recently been conducted. Additionally, as prevalence prediabetes high-risk group diabetes increasing worldwide, in is also rising. However, few studies addressed development type 2 prediabetes. Therefore, aim this longitudinal study was evaluate relationship between prediabetes.We included 14,258 participants with hemoglobinA1c (HbA1c) level...
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC‑1α), a coactivator interacting with multiple transcription factors, regulates several metabolic processes. Although recent studies have focused on the role of PGC‑1α in cancer, underlying molecular mechanism has not been clarified. Therefore, we evaluated cell proliferation and tumorigenesis using human embryonic kidney (HEK)293 cells colorectal cancer cells. We established stable HEK293 lines expressing examined proliferation,...
Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) encompasses a broad continuous spectrum of diseases ranging from fatty to steatohepatitis. The intricate interactions genetic, epigenetic, environmental factors in the development progression MASLD remain elusive. Here, we aimed achieve an integrative understanding genomic transcriptomic alterations throughout MASLD. Approach Results: RNA-Seq profiling (n = 146) whole-exome sequencing 132) tissue samples...
// Seong-Hoon Yun 1 , Eun-Seon Park Sung-Won Shin Mi-Ha Ju 2 Jin-Yeong Han 3 Jin-Sook Jeong Sung-Hyun Kim 4 Valentin A. Stonik 5 Jong-Young Kwak Joo-In Department of Biochemistry, Dong-A University College Medicine, Busan, South Korea Pathology, Laboratory Internal G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far East Division, The Russian Academy Sciences, Vladivostok, Russia Correspondence to: Park, e-mail: jipark@dau.ac.kr Keywords: triterpene glycoside, lipid rafts, ceramide...
Fibronectin (FN) is known to transduce signal(s) rescue cells from detachment-induced apoptosis (anoikis) through an integrin-mediated survival pathway. However, the functions of individual FN domains have not been studied in detail. In present study we investigated whether interaction cell-binding domain with integrin sufficient rat embryo fibroblasts (REFs) apoptosis. REFs attached and spread normally after plating on substrates coated either intact or a fragment, FN120, that contains but...
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such coxsakievirus and adenovirus receptor (CAR). We show here CAR-deficiency in cancer cells, limits adenoviral delivery, can be overcome by using complexed with the liposome, Ad-PEGPE [1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly-ethylene glycol)-2000]. first confirmed CT-26 mouse colon are deficient CAR RT-PCR, then showed infected Ad-GFP/PEGPE exhibited highly...
Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is highly aggressive and lethal zoonotic infection caused by the larval stage of fox tapeworm, Echinococcus multilocularis. E. multilocularis widely distributed in northern hemisphere; disease-endemic area stretches from north America through Europe to central east Asia, including parts Japan, but it has not been reported Korea. Herein, we represent first case AE A 41-year-old woman was found have large mass...