A5100327665- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- FOXO transcription factor regulation
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- T-cell and B-cell Immunology
- Microtubule and mitosis dynamics
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal Tumor Research and Treatment
- Advanced Optical Imaging Technologies
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Cancer-related Molecular Pathways
Korea Research Institute of Chemical Technology
2025
Seoul National University
2016-2025
Korea University
2024-2025
Seoul St. Mary's Hospital
2022-2024
Catholic University of Korea
2002-2024
Hanyang University
2024
National University College
2023
New Generation University College
2011-2023
Korea Electric Power Corporation (South Korea)
2022
Goethe University Frankfurt
2017-2021
Abstract Motivation: For the early detection of cancer, highly sensitive and specific biomarkers are needed. Particularly, in bio-fluids relatively more useful because those can be used for non-biopsy tests. Although altered metabolic activities cancer cells have been observed many studies, little is known about screening. In this study, a systematic method proposed identifying urine samples by selecting candidate from genome-wide gene expression signatures cells. Biomarkers identified...
In this study, we performed metal (Ag, Ni, Cu, or Pd) electroplating of core-shell metallic Ag nanowire (AgNW) networks intended for use as the anode electrode in organic light-emitting diodes (OLEDs) to modify work function (WF) and conductivity AgNW networks. This low-cost facile method enabled precise deposition onto surface at (NW) junctions. AgNWs coated a transparent glass substrate were immersed four different baths: those containing AgNO3 electroplating, NiSO4 Ni Cu2P2O7 Cu PdCl2 Pd...
<h3>Objective</h3> To determine the feasibility of laparoscopic approach for treating suspected early-stage gallbladder carcinoma. <h3>Design, Setting, and Patients</h3> Prospective study from a university hospital. From May 10, 2004, to October 9, 2007, was considered 36 patients with carcinoma at T2 or less without liver invasion based on preoperative computed tomographic scan. further exclude invasion, endoscopic ultrasonography (US) US were additionally performed. Frozen biopsy performed...
Objective Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in blood among patients with virus nephropathy (BKVN). Urinary exosome suggested a possible source biomarker for kidney diseases, but it unknown whether could contain viral microRNA as well human microRNAs. The aim this study evaluate urinary exosomal were expressed during replication and used diagnose BKVN transplant recipients. Materials methods In cross-sectional multicenter study, we...
Purpose We previously reported that forkhead transcription factors of the O class 1 (FOXO1) expression in gastric cancer (GC) was associated with angiogenesis-related molecules. However, there is little experimental evidence for direct role FOXO1 GC. In present study, we investigated effect on tumorigenesis and angiogenesis GC its relationship SIRT1. Materials Methods Stable cell lines (SNU-638 SNU-601) infected a lentivirus containing shRNA were established animal studies as well culture...
The PD-1 (programmed death 1) molecule is a negative regulator of T cells. PDCD1 cell has been reported to have genetic association in systemic lupus erythematosus and rheumatoid arthritis Caucasians. However, there are no reports on the between this gene ankylosing spondylitis (AS). present study investigated polymorphisms haplotypes with AS Korean population sample. In case-control study, two single-nucleotide polymorphisms, PD-1.5 C/T PD-1.9 T/C, were genotyped 95 patients 130 healthy...
Diagnosis techniques using urine are non-invasive, inexpensive, and easy to perform in clinical settings. The metabolites urine, as the end products of cellular processes, closely linked phenotypes. Therefore, metabolome is very useful marker discoveries applications. However, only univariate methods have been used classification studies metabolome. Since multiple genes or proteins would be involved developments complex diseases such breast cancer, compounds including related with diseases,...
The role of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumour-infiltrating lymphocytes (TILs) and prognosis CRC by use image analysis.Immunohistochemical staining for CD68 CD163 was performed as pan-macrophage M2-macrophage markers, respectively. Each marker analysed separately intra-epithelial stromal area densities. All four macrophage densities showed a...
We attempted to elucidate whether p53 expression or TP53 mutation status was associated with cancer-specific survival in adjuvant FOLFOX-treated patients stage III high-risk II colorectal cancer (CRC). analysed CRCs (N = 621) for the presence of alterations and expression, using targeted resequencing immunohistochemistry. were grouped into four subsets according status, which included p53-no, mild, moderate strong expression. The distributions 19.85, 11.05, 17.7% 51.5% groups, respectively....
The long-term effects of radical resection on quality life may influence the treatment selection. objective this study was to determine whether abdominoperineal has a better effect than sphincter preservation surgery at 3 years after surgery.
Abstract Background Interactions between the programmed cell death receptor 1 (PD-1) and its ligand (PD-L1) lead to immune evasion in various tumors are associated with poor prognosis patients pancreatic cancer; however, roles of PD-L1-containing exosomes cancer is poorly understood. Here, we investigated correlation circulating exosomal PD-L1 (exoPD-L1) expression tumor tissue, survival outcomes advanced PDAC. Methods Exosomes were derived from pre-treatment serum samples isolated using...
Claudin-18.2 (CLDN18.2) is specifically expressed in pancreatic precancerous lesions and ductal adenocarcinoma (PDAC). We assessed the clinical characteristics of patients with CLDN18.2-overexpressing cancer to identify who might benefit from CLDN18-targeted treatment. A total 130 surgically resected PDAC were investigated for immunohistochemical expression claudin-18 (CLDN18). The CLDN18 staining intensities (0–3+) relative proportion positive tumor cells analyzed by two independent raters....
The stability of p53 tumor suppressor is regulated by Mdm2 via the ubiquitination and proteasome-mediated proteolysis pathway. c-Abl PTEN suppressors are known to stabilize blocking Mdm2-mediated degradation. This study investigated correlation between merlin, a neurofibromatosis 2 (NF2)-related suppressor, in association with function. results showed that merlin increased inhibiting degradation p53, which accompanied increase p53-dependent transcriptional activity. stabilization appeared be...
Background: Gemcitabine-based chemotherapy is a commonly used first-line treatment for patients with pancreatic and biliary tract cancer. However, standard second-line regimen has yet to be developed after gemcitabine treatment. We attempted evaluate the efficacy safety of combination continuous 5-fluorouracil, doxorubicin, mitomycin-C (conti-FAM) as in Methods: Patients advanced or cancer who were previously treated gemcitabine-based enrolled study. Chemotherapy was administered follows:...
Purpose Lapatinib is a candidate drug for treatment of trastuzumab-resistant, human epidermal growth factor receptor 2 (HER2)–positive gastric cancer (GC). Unfortunately, lapatinib resistance renders this ineffective. The present study investigated the implication forkhead box O1 (FOXO1) signaling in acquired HER2-positive GC cells. Materials and Methods Lapatinib-resistant cell lines (SNU-216 LR2-8) were generated vitro by chronic exposure lapatinib-sensitive, SNU-216 cells to lapatinib. LR...
High-fat diets (HFDs) and frequent consumption of sugar-sweetened beverages (SSBs) are potential contributors to increasing inflammatory bowel disease (IBD) incidences. While HFDs have been implicated in mild intestinal inflammation, the role sucrose SSBs remains unclear. Therefore, we studied IBD pathogenesis a mouse model humans. C57BL6/J mice were given ad libitum access solution or plain water for 10 weeks, with without an HFD. Interestingly, alone did not induce gut inflammation mice;...
Diagnosing primary liver cancers, particularly hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), is a challenging labor-intensive process, even for experts, secondary cancers further complicate the diagnosis. Artificial intelligence (AI) offers promising solutions to these diagnostic challenges by facilitating histopathological classification of tumors using digital whole slide images (WSIs). This study aimed develop deep learning model distinguishing HCC, CC, metastatic colorectal...