A5102844037- Phytoplasmas and Hemiptera pathogens
- Ecology and Conservation Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Renal and related cancers
- Insect-Plant Interactions and Control
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Genetic and Kidney Cyst Diseases
- Genetic diversity and population structure
- Invertebrate Taxonomy and Ecology
- Research on scale insects
- MicroRNA in disease regulation
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Hymenoptera taxonomy and phylogeny
- Parasite Biology and Host Interactions
- Plant Virus Research Studies
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Liver Disease Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- Coleoptera: Cerambycidae studies
Sookmyung Women's University
2017-2024
Chungnam National University
2015-2024
National Institutes of Health
2015-2024
Marine Biodiversity Institute of Korea
2016-2017
National Institute of Diabetes and Digestive and Kidney Diseases
2015-2016
Dankook University
2013-2016
The manila clam, Ruditapes philippinarum, is an important bivalve species in worldwide aquaculture including Korea. production of R. philippinarum under threat from diverse environmental factors viruses, microorganisms, parasites, and water conditions with subsequently declining production. In spite its importance as a marine resource, the reference genome for comprehensive genetic studies largely unexplored. Here, we report de novo whole-genome transcriptome assembly across three different...
One new species of the genus Tautoneura, T. polymitusa sp. nov., is described, and tricolor Anufriev, 1969 japonica (Dworakowska, 1972) are reported from Korea for first time. Descriptions, illustrations a key to Korean Tautoneura provided.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by fat accumulation in the liver. MASLD encompasses both steatosis and MASH. Since MASH can lead to cirrhosis cancer, must be distinguished during patient treatment. Here, we investigate genomes, epigenomes, transcriptomes of patients identify signature gene set for more accurate tracking progression.
Significance Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of PKD1 or PKD2 , leading to end-stage disease. There are few cures for ADPKD, although many researchers trying find a cure. The Hippo signaling pathway regulates organ growth and cell proliferation. Transcriptional coactivator with PDZ-binding motif (TAZ) effector. In this study, we demonstrated that PKD1–TAZ–Wnt–β-catenin–c-MYC axis plays...
Abstract Dendritic cells are antigen-presenting orchestrating innate and adaptive immunity. The crucial role of transcription factors histone modifications in the transcriptional regulation dendritic has been extensively studied. However, it is not well understood whether how three-dimensional chromatin folding controls gene expression cells. Here we demonstrate that activation bone marrow-derived induces extensive reprogramming looping as enhancer activity, both which implicated dynamic...
Signal Transducers and Activators of Transcription (STATs) are principal transcription factors downstream cytokine receptors. Although STAT5A is expressed in most tissues it remains to be understood why its premier, non-redundant functions restricted prolactin-induced mammary gland development function. We report that the ubiquitously Stat5a/b locus subject additional lineage-specific transcriptional control epithelium. Genome-wide surveys epigenetic status factor occupancy uncovered a...
CTCF, Zinc-finger protein, has been identified as a multifunctional transcription factor that regulates gene expression through various mechanisms, including recruitment of other co-activators and binding to promoter regions target genes. Furthermore, it proposed be an insulator protein contributes the establishment functional threedimensional chromatin structures. It can disrupt blocking connection between enhancer promoter. Previous studies revealed onset diseases, breast cancer, could...
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factors STAT5A STAT5B (STAT5), which also regulate temporal activation signature genes. This study addressed question whether methyltransferase transcriptional co-activator EZH2 controls clock epithelium. Ablation Ezh2 from stem cells resulted in precocious alveolar epithelium mammary-specific STAT5 target coincided with enhanced occupancy these loci STAT5, EZH1 RNA Pol...
One new leafhopper species, L. dangjinensis sp. nov. is described, and hebeiensis Cai, Liang & Wang, 1992 reported from Korea for the first time. Descriptions, photographs, illustrations biological information of species are provided. A key to Korean Limassolla also given. macrobipunctata Hossain, Kwon, Suh 2019 synonymised with ishiharai Dworakowska, 1972.
Altered miRNA (miR) expression occurs in various diseases. However, the therapeutic effect of miRNAs autosomal dominant polycystic kidney disease (ADPKD) is unclear. Genome-wide analyses and DNA methylation status were conducted to identify crucial end-stage ADPKD. miR-192 -194 levels down-regulated with hypermethylation at these loci, mainly intermediate late stages, not early stage, cystogenesis, suggesting their potential impact on cyst expansion. Cyst expansion has been strongly...
Establishment of the mammary luminal cell lineage is controlled primarily by hormones and through specific transcription factors (TFs). Previous studies have linked histone methyltransferases to differentiation epithelium, thus opening possibility biological significance counteracting demethylases. We now demonstrated an essential role for H3K27me3 demethylase KDM6A in generating a balanced alveolar compartment. Deletion Kdm6a led paucity cells excessive expansion basal cells, both vivo...
<title>Abstract</title> Vibrational spectroscopy is a powerful tool for spectral imaging of biological samples, thanks to its narrow bandwidth (10 cm⁻¹) compared fluorescence. Single-molecule vibrational has been demonstrated with near-field amplification as in surface-enhanced Raman or fluorescence detection stimulated excited and bond-selective fluorescence-detected infrared-excited spectro-microscopy. However, these methods involve complex sample preparation produce high backgrounds,...
BackgroundPolycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian of rapamycin (mTOR) is key negative regulator autophagy. However, the effect autophagy regulation on cystogenesis not elucidated PKD mice.MethodsClinical validation was performed using GEO datasets autosomal dominant polycystic (ADPKD) patient samples. Newly established LC3 transgenic mice were...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer; however, specific prognostic biomarkers have not yet been developed. In this study, we identified dysregulated microRNAs (miRNAs) in TNBC by profiling miRNA and mRNA expression. patients with TNBC, miR-371b-5p expression was reduced, overexpression significantly mitigated cell growth, migration, invasion. addition, found that cold shock domain-containing protein E1 (CSDE1), a direct target gene...
Cancer stem-like cells (CSCs) have been suggested to be responsible for chemoresistance and tumor recurrence owing their self-renewal capacity differentiation potential. Although WEE1 is a strong candidate target anticancer therapies, its role in ovarian CSCs yet elucidated. Here, we show that plays key regulating CSC properties resistance carboplatin via microRNA-dependent mechanism. We found expression upregulated cancer spheroids because of the decreased miR-424 miR-503, which directly...
After decades-long efforts to diagnose and treat breast cancer, the management strategy that has proved most successful date is molecular-subtype-specific inhibition of hormone receptors HER2 are expressed by individual cancers. Melanoma-associated antigen (MAGE) proteins comprise >40 highly conserved members contain MAGE homology domain. They often overexpressed in multiple cancers contribute cancer progression metastasis. However, it remains unclear whether biological activity arising...
Cancer cells utilize epigenetic alterations to acquire autonomous capabilities for tumor maintenance. Here, we show that pancreatic ductal adenocarcinoma (PDA) super-enhancers (SEs) activate the transcription factor EVI1 (ecotropic viral integration site 1) gene, resulting in activation of an EVI1-dependent program conferring PDA tumorigenesis. Our data indicate SE is vital cis-acting element maintain aberrant cells. Consistent with disease progression and inferior survival outcomes...
본 논문은 교내 기초임상실습 프로그램이 학생들의 학습동기, 비판적 사고 및 임상수행능력 자신감에 미치는 효과를 확인하고자 시도되었다. 프로그램은 2주간 30시간의 과정으로 핵심기본간호술과 필수간호교육으로 구성되었다. 대상자는 첫 임상실습을 앞둔 228명의 간호대학생이었고 프로그램 전후에 설문지를 통해 자료를 수집하였다. 자료수집기간은 2013년 2월 18일부터 28일까지 10일 이었다. 연구결과 비판적사고에는 영향을 미치지 않는 것으로 나타났고, 학습동기의 하부영역 중 우울과 시험불안은 유의하게 상승하였고, 학업스트레스는 감소하였으며 자기효능감은 상승하였다. 자신감은 전 영역에서 상승한 나타났다 연구결과를 간호학생들의 임상실습 수행 역량을 강화시키는데 효과가 있음을 확인하였다. 추후연구에서는 중재의 높이기 위해 프로그램의 내용을 다양화하고 운영기간을 늘릴 것을 제언한다. The purpose of this study was to identify the effects basic...
Cancer metastasis is the primary cause of cancer-related death and metastatic cancer has circulating-tumor cells (CTCs), which circulate in bloodstream before invading other organs. Thus, understanding precise role CTCs may provide new insights into process reduce mortality. However, molecular characteristics are not well understood due to a lack number CTCs. Therefore, suspension were generated from MDA-MB-468 mimic CTCs, we investigate microRNA (miRNA)-dependent networks their cells. Here,...
Other SectionsABSTRACTINTRODUCTIONNGS TECHNIQUES FOR DETECTING MODIFICATIONS OF DNA, CHROMATIN STRUCTURE, AND RNADISCOVERING BIOMARKERS LIVER DISEASE THROUGH NGS DATAINTEGRATIVE ANALYSIS WITH TRANSCRIPTOME OTHER SEQUENCING APPLICATIONSCONCLUSIONACKNOWLEDGEMENTSCONFLICTS INTERESTREFERENCES
Abstract Ticks are vectors of disease‐causing pathogens and found on domestic wild animals; thus, they also significant human diseases. For this reason, pre‐emptive measures to prevent tick‐borne diseases necessary in the form exploring their major habitats, population increase period, factors affecting growth, all which indicate purpose study. In study, a variation Haemaphysalis longicornis , vector fever‐causing conditions, was statistically analyzed identify spatial climatic...
Dysregulated DNA methylation in cancer is critical the transcription machinery associated with progression. Triple-negative breast (TNBC) most aggressive subtype, but no treatment targeting TNBC biomarkers has yet been developed. To identify specific patterns TNBC, methyl-binding domain protein 2 (MBD) sequencing data were compared and three other major subtypes. Integrated analysis of gene expression identified a set showing correlation between expression. ATPase Na+/K+-transporting subunit...