A5102997616- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Ophthalmology and Eye Disorders
- Hereditary Neurological Disorders
- Systemic Sclerosis and Related Diseases
- Parkinson's Disease and Spinal Disorders
- Neurogenetic and Muscular Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- CNS Lymphoma Diagnosis and Treatment
- Spinal Cord Injury Research
- Autoimmune and Inflammatory Disorders Research
- Migraine and Headache Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parathyroid Disorders and Treatments
- Protein Tyrosine Phosphatases
- Autoimmune Neurological Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Trigeminal Neuralgia and Treatments
- Vasculitis and related conditions
Sungkyunkwan University
2016-2025
Samsung Medical Center
2016-2025
Samsung (South Korea)
2021-2025
Korea Health Promotion Institute
2025
Korea University
2024
Seoul National University Hospital
2004-2023
Neurology, Inc
2022
Palmetto Hematology Oncology
2021
Myongji Hospital
2010
Catholic Kwandong University
2010
We report the case of a patient who developed extensive brain lesions during fingolimod (FTY720) treatment in TRANSFORMS study. His initial diagnosis was multiple sclerosis, but after encephalopathy anti-aquaporin4 antibody (anti-AQP4 Ab) detected, it changed to neuromyelitis optica spectrum disorder. After with fingolimod, he bilateral lesions. The MRI showed predominantly involving right frontal and parietal lobes, vasogenic edema enhancement. He had residual encephalomalacia no recurrence...
Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, even present with symptomatic involvement.We investigated whether MRI onset can be helpful for the differentiation of MS NMOSD.We retrospectively analyzed initial MRIs, performed within three months in patients (n = 51)...
Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The divided into two groups based on age onset: (⩾50 years at onset) versus early-onset (EO-NMOSD) (<50 onset). Clinical, laboratory, and magnetic resonance imaging...
Abstract Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory disorders of the central nervous system (CNS) with similar characteristics. The differential diagnosis between MS NMOSD is critical for initiating early effective therapy. In this study, we developed a deep learning model to differentiate multiple using brain magnetic resonance imaging (MRI) data. was based on modified ResNet18 convolution neural network trained 5-channel images...
Background Myelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG AQP4-IgG, mostly the IgG1 subtype, can both activate complement system. Therefore, we investigated whether levels serum components, regulators, activation products differ between MOGAD AQP4-NMOSD,...
To evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) with oral solubilized formula in amyotrophic lateral sclerosis (ALS) patients, patients probable or definite ALS were randomized to receive UDCA (3.5 g/140 mL/day) placebo for 3 months after a run-in period 1 month switched other treatment wash-out month.The primary outcome was rate progression, assessed by Appel rating scale (AALSRS), secondary outcomes revised functional (ALSFRS-R) forced vital capacity (FVC).Fifty-three...
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue quality of life (QOL). We aimed evaluate the severity its relationship QOL patients NMOSD. prospectively studied NMOSD who were remission seropositive for anti-aquaporin-4 antibody, they divided into 2 groups based...
Background In neuromyelitis optica spectrum disorder (NMOSD), brain involvement is common and cognitive dysfunction frequently found. The study investigated alterations of white matter (WM) connectivity using graph theory correlations with in patients NMOSD. Methods We prospectively enrolled NMOSD (N=14) age- sex-matched healthy controls (N=21). Structural connections between any pair the 90 cortical subcortical regions were established diffusion tensor imaging theory. Network-based...
Importance A proportion of people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have a relapsing course and persistent anti–myelin immunoglobulin G (MOG-IgG) seropositivity. Few studies investigated whether treatment the first MOGAD attack is associated long-term and/or MOG-IgG seronegative conversion. Objective To investigate association time to treat acute relapse risk serostatus. Design, Setting, Participants This was retrospective, nationwide, multicenter...
Treatments for neuromyelitis optica spectrum disorder (NMOSD) such as eculizumab, ravulizumab, satralizumab, and inebilizumab have significantly advanced relapse prevention, but they remain expensive. Rituximab is an off-label yet popular alternative that offers a cost-effective solution, its real-world efficacy needs better quantification guiding the application of newer approved NMOSD treatments (ANTs). This study aimed to determine rituximab failure rates anticipate demand ANTs aid in...
Studies have highlighted complex bidirectional relationships between autoimmune diseases and depressive disorders. Given that early mental health interventions substantial public implications, this study investigated association optic neuritis, an inflammatory disorder of the nerve, risk developing Utilizing extensive national insurance data encompassing almost entire Korean population, cohort included 11,745 patients with neuritis 58,725 age- sex- matched controls 2010 2017. The diagnosis...
Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates disability or disease activity. Vitamin may play a role in neuromyelitis optica (NMO) NMO spectrum disorder (NMOSD), as an important factor involved immunological pathways. We investigated the relationship between vitamin and related clinical activity patients NMOSD. Blood samples from 51 NMOSD who were positive for anti-aquaporin4-antibody (AQP4-ab) 204 healthy controls collected...
As most of patients with Myasthenia Gravis have limitations in their physical functioning, many experience changes psychological states and often depression. The objective the current study was to examine roles communication medical professionals, patients' loneliness, depression, relation effects on quality life.For 120 MG 18 years older, demographic variables, along life were measured.As a result, people suffering from experienced lower when career has changed due illness. At same time,...
Differentiation of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) is important, but an effective tool for differentiation has not been identified. We investigated the efficacy composite autonomic symptom scale 31 (COMPASS 31) questionnaire as a evaluating function in patients. In this study, we enrolled drug-naïve patients MSA-P PD, administered COMPASS-31 objective dysfunction test (AFT). Demographic clinical data, including dysfunction, were...
Cognitive impairment is a common feature of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). However, there lack population-based study dementia risk in these disorders. In the present study, MS NMOSD patients Republic Korea was estimated.Data analyzed this were obtained from Korean National Health Insurance Service (KNHIS) database between January 2010 December 2017. The included 1,347 1,460 ≥40 years age who had not been diagnosed with within 1 year prior to...
Background: The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder.We evaluated the performance cell-based indirect immunofluorescence assay (CIIFA) for detecting AQP4 using antigen prepared with recombinant peptide transfection technique and assessed usefulness CIIFA diagnosis NMOSD in routine clinical practice.Methods:...
We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, microbleeds. Subjects considered to an abnormally elevated urine albumin creatinine ratio if value was ≥17 mg/g...