A5040025378- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Educational Research and Pedagogy
- Education and Learning Interventions
- Educational Systems and Policies
- Education, Safety, and Science Studies
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Building Energy and Comfort Optimization
- Advanced MRI Techniques and Applications
- Numerical methods in engineering
- Healthcare and Venom Research
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Cardiac Imaging and Diagnostics
- Refrigeration and Air Conditioning Technologies
- Asian Culture and Media Studies
- Multiple Sclerosis Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Atrial Fibrillation Management and Outcomes
- Ultrasonics and Acoustic Wave Propagation
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Diverse Approaches in Healthcare and Education Studies
Sungkyunkwan University
2014-2025
Kangwon National University
2008-2024
Gwangju Health University
2022-2024
Korea Research Institute of Chemical Technology
2013-2024
Korea University of Science and Technology
2024
Changwon National University
2022-2024
Gyeongsang National University
2011-2024
Korea University
2008-2024
Kyungpook National University
2012-2024
Metropolitan Research Institute
2024
Collaterals sustain the penumbra before recanalization and offset infarct growth, yet influence of baseline collateral flow on after endovascular therapy remains relatively unexplored.We analyzed consecutive patients who received for acute cerebral ischemia from 2 distinct study populations. We assessed relationship between pretreatment grade vascular (Thrombolysis In Myocardial Ischemia [TIMI] scale). addition, we growth serial MRI.A total 222 was included, 138 United States 84 South Korea....
We report the case of a patient who developed extensive brain lesions during fingolimod (FTY720) treatment in TRANSFORMS study. His initial diagnosis was multiple sclerosis, but after encephalopathy anti-aquaporin4 antibody (anti-AQP4 Ab) detected, it changed to neuromyelitis optica spectrum disorder. After with fingolimod, he bilateral lesions. The MRI showed predominantly involving right frontal and parietal lobes, vasogenic edema enhancement. He had residual encephalomalacia no recurrence...
Background and Purpose— Collaterals sustain the ischemic penumbra to limit growth of infarct core before revascularization, yet impact baseline collateral flow on hemorrhagic transformation (HT) after endovascular therapy remains unknown. Methods— A collaborative study from 2 stroke centers in distinct geographic regions included 222 consecutive patients who received for acute cerebral ischemia. The influence collaterals HT was analyzed case scenarios relative grade at angiography (0 1...
Alginate-only, cell-laden, and protein-immobilized hollow fibers are produced (see image). Cells remain alive within the due to nontoxic fabrication process. Vascular tissue can be emulated by embedding endothelial cells into alginate then these cell-laden smooth-muscle-cell-laden AGF hydrogels. Detailed facts of importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please...
The long-term, continuous, inconspicuous and noiseless monitoring of bioelectrical signals is critical to the early diagnosis disease health wellbeing. However, it a major challenge record patients going about their daily lives because difficulties integrating skin-like conducting materials, measuring system medical technologies in single platform. In this study, we developed thin epidermis-like electronics that capable repeated self-adhesion onto skin, integration with commercial electronic...
We developed microfluidic-based pure chitosan microfibers (∼1 meter long, 70–150 μm diameter) for liver tissue engineering applications. Despite the potential of creating bio-artificial chips, its major limitation is inability to fabricate chitosan-based microstructures with controlled shapes because mechanical weakness chitosan. Previous studies have shown that micro/nanofibers can be fabricated by using chemicals and electrospinning techniques. However, there no paper regarding in a...
Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the lumen of large intestine and produces toxins. This results in range syndromes from mild diarrhea to severe toxic megacolon death. Alarmingly, prevalence severity C. infection are increasing; thus, associated morbidity mortality rates rising. 4-Aminothiazolyl analogues antibiotic natural product GE2270 A (1) were designed, synthesized, optimized for treatment infection. The medicinal chemistry effort...
The mechanisms by which nitric oxide (NO) influences myocardial Ca2+ cycling remain controversial. Because NO synthases (NOS) have specific spatial localization in cardiac myocytes, we hypothesized that neuronal NOS (NOS1) found sarcoplasmic reticulum (SR) preferentially regulates SR release and reuptake resulting potentiation of the force-frequency response (FFR). Transesophageal pacing (660 to 840 bpm) intact C57Bl/6 mice (WT) stimulated both contractility (dP/dtmax normalized...
In this paper, we introduce a novel cylindrical channel that generates coaxial flow without using glass microcapillary or complicated silicon processing, and demonstrate the fabrication of microparticles microfibers channel. The simple process for channels employs deflection free-standing thin PDMS membranes. Using channel, alginate were fabricated clogging downstream dimensions these particles fibers could be successfully controlled by regulating rate through channels. We also developed...
Background and Purpose— To investigate the association between thyroid autoantibodies moyamoya disease (MMD) in patients with an apparent euthyroid state. Methods— We prospectively studied angiographically diagnosed MMD. compared demographic profiles, function test, autoantibody status MMD control groups. Results— A total of 63 MMD, 71 non-MMD stroke, 200 healthy subjects were included. The prevalence elevated was higher group than other groups ( P <0.01 for versus non-MMD; <0.001...
Background Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, the expression mechanism colonic epithelial cells (CECs) remains elusive. We investigated role IL-6 CECs using a colitis model. Methods expression, signal transducer activator transcription 3 (STAT3)...
Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, even present with symptomatic involvement.We investigated whether MRI onset can be helpful for the differentiation of MS NMOSD.We retrospectively analyzed initial MRIs, performed within three months in patients (n = 51)...
Dedicated magnetic resonance (MR) imaging (MRI) sequences for evaluation of collaterals can be generated using MR perfusion (MRP) source data. We compared a novel collateral flow technique with digital subtraction angiography (DSA) determining circulation in acute stroke and evaluated the ability MR-based maps to predict outcomes after recanalization therapy.Consecutive patients who were candidates endovascular treatment enrolled. A map derived from MRP data was by manual or automatic...
Background Both Moyamoya disease (MMD) and intracranial atherosclerotic stenosis (ICAS) are more prevalent in Asians than Westerners. We hypothesized that a substantial proportion of patients with adult-onset MMD were misclassified as having ICAS, which may part explain the high prevalence stroke Asians. Method analyzed 352 consecutive ischemic events within MCA distribution relevant arterial stenosis, but no demonstrable carotid or cardiac embolism sources. Conventional angiography was...
Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The divided into two groups based on age onset: (⩾50 years at onset) versus early-onset (EO-NMOSD) (<50 onset). Clinical, laboratory, and magnetic resonance imaging...