A5008393513- 3D Printing in Biomedical Research
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
- Mechanical Circulatory Support Devices
- Pluripotent Stem Cells Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Astrophysics and Star Formation Studies
- Liver physiology and pathology
- Electrospun Nanofibers in Biomedical Applications
- Hydraulic and Pneumatic Systems
- Astronomical Observations and Instrumentation
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Cellular Mechanics and Interactions
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Genomics and Diagnostics
- Cardiac Arrest and Resuscitation
- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
- Advanced Sensor and Energy Harvesting Materials
- Diabetes and associated disorders
Max Planck Institute for Human Cognitive and Brain Sciences
2025
Asan Medical Center
2017-2024
University of Ulsan
2016-2024
Ulsan College
2018-2024
Korea University
2007-2021
Kyungpook National University
2021
Southerners on New Ground
2019
Korea Astronomy and Space Science Institute
2015-2018
Korea University of Science and Technology
2015-2018
Seoul Institute
2014
Abstract Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals, driving a need for personalised medicine. Here, we report lung organoids normal bronchial established from patient tissues comprising five histological subtypes of non-neoplastic mucosa as in vitro models representing individual patient. The recapitulate the tissue architecture primary tumours maintain genomic alterations original during long-term expansion vitro. cellular components mucosa....
There has been a growing need for in vitro models of neurodegenerative diseases such as Alzheimer's disease that would enable better understanding etiology and faster development treatment strategies. However, meeting this demand held back by the limited ability to mimic vivo microenvironment an system. Here, we developed microfluidic chip based on three-dimensional (3D) neurospheroids more closely mimics brain providing constant flow fluid is readily observed interstitial space brain....
Microfluidic devices as translational research tools offers opportunities to aid in reliable medical decision making and develop customized patient care through predictive modeling of drug sensitivity patient-derived cancer organoids.
Microfluidic cell culture assays are versatile tools for studying migration, particularly angiogenesis. Such can deliver precisely controlled linear gradients of chemical stimuli to cultured cells in a microfluidic channel, offering excellent optical resolution and situ monitoring cellular morphogenesis response gradient. provide gradient subject molecular diffusion, although metabolism perturb it. The actual perturbed by has not been described the context regulated morphogenesis. We modeled...
Abstract In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo , bridging the gap between conventional 2D testing and animal models. Stromal tissues with extracellular matrix (ECM) can provide a microenvironment (TME) cell-to-cell cell-to-ECM interactions. These interactions induce exchange of biophysical factors, contributing to progression, metastasis, drug resistance cancer. Here, we describe 3D lung model cultured microfluidic channel that is able confirm role...
The creation and characterization of large-area ultrathin highly pliable free-standing PDMS membranes their application to the study cellular epithelia is described. ultra-thin permitted straight forward calculation cell monolayer moduli, derived from measured stress–strain curves. These measurements allowed unprecedented detection cellular-level injury in caused by rupture cell–cell tight junctions response stretching. As a service our authors readers, this journal provides supporting...
In most animals, the nervous system consists of central (CNS) and peripheral (PNS), latter which connects CNS to all parts body. Damage and/or malfunction causes serious pathologies, including neurodegenerative disorders, spinal cord injury, Alzheimer's disease. Thus, not surprising, considerable research effort, both in vivo vitro, has been devoted studying signal transmission through it. However, conventional vitro cell culture systems do enable control over diverse aspects neural...
Precise control of media delivery to cells in microfluidic systems a simple and efficient manner is challenge for number cell-based applications. Conventional syringe pumps can deliver culture into devices at precisely controlled flow rates, but they are bulky require power source. On the other hand, passive microflow-generating cannot maintain continuous, controllable long-term media. We have developed an on-chip microflow technology that combines rate passive, microwell tissue chambers....
Abstract The purpose of this study was to demonstrate self‐organizing in vitro multicellular tumor spheroid (MCTS) formation a microfluidic system and observe the behavior MCTSs under controlled microenvironment. employed designed for simple effective by generating nutrient oxygen gradients. were composed cancer cells, vascular endothelial type I collagen matrix mimic vivo microenvironment (TME). Cell culture medium perfused device loaded with passive fluidic pump at constant flow rate. dose...
Abstract In the adult brain, hemodynamic responses to visually presented numerosities reveal receptive field-like tuning curves in topographically organized maps across association cortices. It is currently unknown whether such tuned topographic can also be detected developing brain. Here we conducted a 7 Tesla fMRI experiment which large set of visual dot displays 11-12-year-old children and adults. We found that indeed revealed logarithmic Gaussian quantitative information. Tuning models...
Abstract Embryonic stem cells (ESCs) are pluripotent and capable of self‐renewal. ESC aggregates, termed embryoid bodies (EBs), have been widely adopted as an in vitro differentiation model. However, the mass production uniform size shaped EBs has challenging. Herein is described development a culture plate containing large number concave microwells with minimal use tools, labor, skill, cost, enabling homogeneous simultaneously using plate. The well structures self‐constructed through...
Abstract High-aspect ratio micro- and nano-structures have been used for the production of a variety applications. In this paper, we describe simple cost-effective approach to fabricate an arrayed microarchitecture with ultra-high aspect using soft materials. The shapes sizes honeycomb structure can be easily modulated by changing dimensions position base mould pattern pressure. is prepare drug delivery patch microwell array form cell spheroids without loss. structures prepared natural ECM...
Homing of peripheral stem cells is regulated by one the most representative homing factors, stromal cell-derived factor 1 alpha (SDF-1α), which specifically binds to plasma membrane receptor CXCR4 mesenchymal (MSCs) in order initiate signaling pathways that lead directional migration and cells. This complex process have been mimicked on a microfluidic device capable generating chemokine gradient within collagen matrix embedding endothelial cell (EC) monolayers mimic blood vessels. On device,...
Differential chemo-sensitivity of cancer cells, which is attributed to the cellular heterogeneity and phenotypic variation considered be main reason for tumor recurrence after chemotherapy. Here, we generated small cell lung patient-derived organoids subjected them long-term expansion with addition WNT3A or R-spondin1. We confirmed that have similar genetic profiles, molecular characteristics, morphological architectures corresponding patient tissue during expansion. Interestingly, reflected...
Embryonic stem cells (ESCs) have attracted great interest in the fields of tissue engineering, regenerative medicine, and organogenesis for their pluripotency ability to self-renew. ESC aggregation, which produces an embryoid body (EB), has been widely utilized as a trigger vitro directed differentiation. In this paper, we propose novel method constructing large numbers deep concave wells PDMS microfluidic chips using meniscus induced by surface tension liquid prepolymer, applied chip mass...
Stimuli-responsive hydrogels have attracted considerable interest in the field of microfluidics due to their ability transform electrical energy directly into mechanical work through swelling, bending, and other deformations. In particular, electroactive hold great promise for biomedical micropumping applications such as implantable drug delivery systems. applications, consumption rate durability are key properties. Here, we developed a valveless micropump system that utilizes hydrogel main...
Gastric cancer (GC) is a leading cause of death worldwide and in urgent need targeted drug development. In the current, we investigated ability repositioned verteporfin (VP), originally treatment for macular degeneration, to inhibit GC cell growth. VP inhibited growth various lines. Gene expression profiling lines treated with revealed that migration-related genes those oncogenic potential were down-regulated. Of these genes, found FAT1, an adhesion molecule promoting invasion, was highly...
Aims. The purpose of this paper is to detect and investigate the nature long-term radial velocity (RV) variations K-type giants confirm planetary companions around stars. Methods. We have conducted two planet search programs by precise RV measurement using 1.8 m telescope at Bohyunsan Optical Astronomy Observatory (BOAO) 1.88 Okayama Astrophysical (OAO). BOAO program searches for planets 55 early K giants. OAO looking 190 G-K type Results. In paper, we report detection long-period three...