A5031300326- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Myasthenia Gravis and Thymoma
- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Hereditary Neurological Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ophthalmology and Eye Disorders
- Obstructive Sleep Apnea Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease and Spinal Disorders
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- CNS Lymphoma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Ocular Diseases and Behçet’s Syndrome
- Parathyroid Disorders and Treatments
- Neurological disorders and treatments
Soonchunhyang University
2017-2025
Soonchunhyang University Hospital
2018-2025
Chungnam National University Hospital
2023
Massachusetts General Hospital
2023
Harvard University
2023
Seoul National University Hospital
2021
Chung-Ang University Hospital
2020
Weatherford College
2019
Sungkyunkwan University
2008-2017
Samsung Medical Center
2009-2017
It has been reported that embolic signal (ES) detected by transcranial Doppler (TCD) clinical significance, especially in patients with recent stroke attributable to arterial or cardiac embolism. Therefore, we conducted this study determine whether the prevalence of ES is high ischemic cancer and related hypercoagulopathy.We prospectively studied acute within middle cerebral artery (MCA) distribution on diffusion-weighted imaging. Conventional mechanisms (CSMs) were determined using...
Patients with active cancer are at an increased risk for stroke. Hypercoagulability plays important role in cancer-related We aimed to test whether 1) hypercoagulability is a predictor of survival, and 2) correction the hypercoagulable state leads better survival patients stroke cancer.We recruited consecutive acute ischemic systemic between January 2006 July 2015. was assessed using plasma D-dimer levels before after 7 days anticoagulation treatment. The study outcomes included overall...
Cancer and ischemic stroke are two of the most common causes death among elderly, associations between them have been reported. However, main pathomechanisms in cancer patients not well known, can only be established based on accurate knowledge characteristics cancer-related strokes. We review herein recent studies concerning clinical, laboratory, radiological features with stroke.This covers epidemiology, underlying mechanisms, acute preventive treatments for stroke. First, (clinical...
Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The divided into two groups based on age onset: (⩾50 years at onset) versus early-onset (EO-NMOSD) (<50 onset). Clinical, laboratory, and magnetic resonance imaging...
Abstract Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory disorders of the central nervous system (CNS) with similar characteristics. The differential diagnosis between MS NMOSD is critical for initiating early effective therapy. In this study, we developed a deep learning model to differentiate multiple using brain magnetic resonance imaging (MRI) data. was based on modified ResNet18 convolution neural network trained 5-channel images...
Background Myelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG AQP4-IgG, mostly the IgG1 subtype, can both activate complement system. Therefore, we investigated whether levels serum components, regulators, activation products differ between MOGAD AQP4-NMOSD,...
Most clinical trials have focused on the presence of perfusion- and diffusion-weighted imaging (PWI–DWI) mismatch by more than 20%, different stroke subtypes were lumped together. We hypothesized that intracranial large artery atherosclerotic (IC-LAA) would show PWI–DWI magnetic resonance angiography (MRA)–DWI profiles, compared with other subtypes. Consecutive patients underwent pretreatment multiparametric for acute middle cerebral infarcts within 6 h symptom onset. assessed difference in...
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue quality of life (QOL). We aimed evaluate the severity its relationship QOL patients NMOSD. prospectively studied NMOSD who were remission seropositive for anti-aquaporin-4 antibody, they divided into 2 groups based...
Background In neuromyelitis optica spectrum disorder (NMOSD), brain involvement is common and cognitive dysfunction frequently found. The study investigated alterations of white matter (WM) connectivity using graph theory correlations with in patients NMOSD. Methods We prospectively enrolled NMOSD (N=14) age- sex-matched healthy controls (N=21). Structural connections between any pair the 90 cortical subcortical regions were established diffusion tensor imaging theory. Network-based...
Increasing evidence suggests an association between SARS-CoV-2 vaccines and Guillain-Barré syndrome (GBS). Nevertheless, little is understood about the contributing risk factors clinical characteristics of GBS post vaccination. In this prospective surveillance study 38,828,691 vaccine doses administered from February 2021 to March 2022 in Gyeonggi Province, South Korea, 55 cases were reported We estimated incidence rate per million ratio for dose, mechanism, age, sex. Additionally, we...
Importance A proportion of people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have a relapsing course and persistent anti–myelin immunoglobulin G (MOG-IgG) seropositivity. Few studies investigated whether treatment the first MOGAD attack is associated long-term and/or MOG-IgG seronegative conversion. Objective To investigate association time to treat acute relapse risk serostatus. Design, Setting, Participants This was retrospective, nationwide, multicenter...
Background: Rituximab (RTX) is a well-known effective treatment for neuromyelitis optica spectrum disorder (NMOSD). Aims: To investigate the effectiveness of RTX in patients with NMOSD and compared medical expenses between other oral agents. Methods: Using data from National Health Insurance System database (2010−2021), we time to first relapse after each medication groups Also, analyzed association level disability type drugs. Results: A total 899 were included, they divided into two...
Treatments for neuromyelitis optica spectrum disorder (NMOSD) such as eculizumab, ravulizumab, satralizumab, and inebilizumab have significantly advanced relapse prevention, but they remain expensive. Rituximab is an off-label yet popular alternative that offers a cost-effective solution, its real-world efficacy needs better quantification guiding the application of newer approved NMOSD treatments (ANTs). This study aimed to determine rituximab failure rates anticipate demand ANTs aid in...
As most of patients with Myasthenia Gravis have limitations in their physical functioning, many experience changes psychological states and often depression. The objective the current study was to examine roles communication medical professionals, patients' loneliness, depression, relation effects on quality life.For 120 MG 18 years older, demographic variables, along life were measured.As a result, people suffering from experienced lower when career has changed due illness. At same time,...
Differentiation of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) is important, but an effective tool for differentiation has not been identified. We investigated the efficacy composite autonomic symptom scale 31 (COMPASS 31) questionnaire as a evaluating function in patients. In this study, we enrolled drug-naïve patients MSA-P PD, administered COMPASS-31 objective dysfunction test (AFT). Demographic clinical data, including dysfunction, were...
The aim of this study was to investigate hidden hearing loss in patients with Charcot-Marie-Tooth disease type 1 A (CMT1A), a common inherited demyelinating neuropathy. By using pure-tone audiometry, 43 CMT1A and 60 healthy controls normal sound detection abilities were enrolled. Speech perception quiet noisy backgrounds, spectral ripple discrimination (SRD), temporal modulation (TMD) measured. Although had similar thresholds speech scores background, significantly (p < 0.05) decreased...
Neuromyelitis optica spectrum disorder (NMOSD) causes relapsing inflammatory attacks in the central nervous system, leading to disability. As rituximab, a B-lymphocyte-depleting monoclonal antibody, is an effective preventing NMOSD relapses, we hypothesised that earlier initiation of rituximab can also reduce long-term disability patients with NMOSD.This multicentre retrospective study involving 19 South Korean referral centres included aquaporin-4 antibodies receiving treatment. Factors...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic small-vessel vasculitis accompanied by asthma, eosinophilia, and eosinophilic inflammation of various tissues including the peripheral nerves. This study investigated clinical course long-term outcomes neuropathy in patients EGPA.Seventy-one physician-diagnosed EGPA were identified at Samsung Medical Center between January 1995 April 2014. Sixty-one these followed-up for more than 1 year received corticosteroid therapy...
Background: Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea.We performed population-based study examine the of NMOSD Korea using data from Korean National Health Insurance (NHI) claims database.Methods: Data 2013 2017 were obtained, with washout period set as 2014.The 2016 calculated population census data.Subjects divided into 5 groups at 15-year intervals, depending on age which...
Abstract Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored relationship between subcortical structures and severity to identify neural substrates of NMOSD. Clinical characteristics brain magnetic resonance imaging were evaluated forty Fatigue was assessed using Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue)....
Abstract Study Objectives To characterize emotion regulation strategies in patients with idiopathic REM sleep behavior disorder (iRBD) and to explore whether these are associated clinical symptoms. Methods In this cross-sectional multicenter study, a total of 94 polysomnography-confirmed iRBD (mean age, 67.6 years; men, 56%) 50 healthy controls 65.4 48%) completed the Cognitive Emotion Regulation Questionnaire (CERQ), Korean version RBD questionnaire-Hong Kong (RBDQ-KR), Buss-Durkee...