A5086471391- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Soft tissue tumor case studies
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Vascular Malformations Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Renal and related cancers
- Neuroendocrine Tumor Research Advances
- Head and Neck Surgical Oncology
- Amyotrophic Lateral Sclerosis Research
- Tuberous Sclerosis Complex Research
- Teratomas and Epidermoid Cysts
- Cell Adhesion Molecules Research
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
National Cancer Center
2010
Hallym University
2008
Seoul National University
1987-2007
Konkuk University Medical Center
2007
Samsung (United States)
2005
Samsung (South Korea)
1997
Seoul National University Children's Hospital
1994
Abstract Advanced metastatic cancer poses utmost clinical challenges and may present molecular cellular features distinct from an early-stage cancer. Herein, we single-cell transcriptome profiling of lung adenocarcinoma, the most prevalent histological type diagnosed at stage IV in over 40% all cases. From 208,506 cells populating normal tissues or early to 44 patients, identify a cell subtype deviating differentiation trajectory dominating stage. In stages, stromal immune dynamics reveal...
<h3>BACKGROUND AND PURPOSE:</h3> Methylation of the <i>MGMT</i> gene promoter is associated with a favorable prognosis in adult patients GBM treated TMZ. We determined incidence pseudoprogression according to methylation status and potential value DSC perfusion MR images for predicting pseudoprogression. <h3>MATERIALS METHODS:</h3> New or enlarged enhancing lesions after CCRT newly diagnosed GBMs were prospectively assessed by measuring their rCBV using images. Tumor tissue was assayed...
To describe the radiographic and computed tomographic (CT) findings in seven patients with nonspecific interstitial pneumonia fibrosis (NIP).NIP was proved pathologically all patients. Findings at radiography initial 1-15-month follow-up CT were reviewed.The predominant abnormalities areas of patchy parenchymal opacification present bilaterally middle lower lung zones six patients; one patient, chest radiograph depicted no abnormality. The most common finding observed on thin-section scans...
The prognosis for patients with recurrent glioblastomas (GBMs) is dismal, a median survival of 3-6 months. We performed phase II trial low-dose continuous (metronomic) treatment using temozolomide (TMZ) GBMs. TMZ-refractory GBM who experienced disease recurrence or progression during after the cyclic schedule TMZ surgery and standard radiotherapy were eligible. This included 2 cohorts patients. initial cohort, comprising 10 patients, received at 40 mg/m(2) everyday. After this regimen seemed...
OBJECTIVEThe authors conducted this retrospective study to investigate the clinical outcomes of intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), defined according 2016 WHO classification central nervous system (CNS) tumors.METHODSHistopathologically proven SFT HPC cases treated in period from June 1996 September 2014 were retrospectively reviewed analyzed. Two neuropathologists pathological slides regraded specimens classification. Factors associated with...
The accurate diagnosis and classification of gliomas are essential for appropriate treatment planning prognosis prediction. This study aimed to investigate the molecular diagnostics IDH-wildtype diffuse astrocytic identify potential genetic variants that could differentiate glioblastoma (GBM) from lower-grade when DNA methylation analysis is not feasible. In total, 479 H3-and were included in this study. All cases diagnosed according 2021 World Health Organization (WHO) central nervous...
Functional defects and morphological changes of mitochondria have been reported to be in the skeletal muscle patients with amyotrophic lateral sclerosis (ALS). Recent studies suggested that mitochondrial abnormalities are related pathogenesis ALS. The purpose this study is evaluate ultrastructural ALS patients. authors examined 49 cases diagnostic biopsy samples definite or probable by electron microscopy. Of cases, 5 (10%) had mitochondria, including giant paracrystalline inclusions,...
Summary: Purpose: To assess the magnetic resonance imaging (MRI), positron emission tomography (PET), pathology, and clinical findings of patients with MRI feature white‐matter change (WMC) in anterior temporal lobe. Methods: Fifty‐six pathologically proven mesial sclerosis were included this study. 18 F‐2‐deoxyglucose‐(FDG) PET images obtained before surgery all patients. The divided into two groups according to presence WMC on their MRI. consists an indistinct gray‐white matter demarcation...
The purpose of this study was to correlate CT findings congenital cystic adenomatoid malformation (CCAM) the lung with pathologic findings.CT scans CCAM from 21 consecutive patients were analyzed retrospectively by two chest radiologists who achieved consensus. Pathologic assessed an experienced pulmonary pathologist. Preoperative correlated findings.Areas small cysts (< 2 cm in diameter) seen on 19 (90%) patients, whereas areas a large cyst (> observed 18 (86%). Areas consolidation (n = 9;...
Background BRAF mutation has received a great deal of attention in neuro‐oncology field, recently. This study aimed to investigate the incidence and clinical significance V600E low‐grade glial tumors. Methods An institutional cohort 105 brain tumors (51 dysembryoplastic neuroepithelial (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM‐N), 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for presence by...
Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because its poor prognosis and limited information. To gain comprehensive view the alterations in GS to understand molecular etiology GS, we applied whole-exome sequencing analyses for 28 cases (6 blood-matched fresh-frozen tissues discovery set, 22 formalin-fixed paraffin-embedded validation set) copy-number variation microarrays 5 tissues. TP53 mutations were more prevalent (20/28, 70%)...
Abstract Preeclampsia is one of the most serious complications pregnancy, affecting 5–10% parturients worldwide. Recent studies have suggested that autophagy involved in trophoblast invasion and may be associated with defective placentation underlying preeclampsia. We thus aimed to understand mechanistic link between invasion. Using two commonly used cell lines, JEG-3 HTR-8/SVneo, we inhibited by ATG5 beclin-1 shRNA. Conversion LC3-II was evaluated knock-down cells presence lysosomal...
Purpose: The purpose of this work was to compare the use MRI and [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in diagnosis focal cortical dysplasia (FCD). Method: Nineteen patients with surgically proven FCD were analyzed retrospectively. performed all patients, FDG-PET 17 patients. We compared MR findings according histologic that classified into three grades. Results: Four cases as Grade I, 4 II, 11 III FCD. lesions detected on 9 (82%) only 1 (13%) 8 I II Cortical...
<h3>Background</h3> Autologous fat injection into the face is a commonly used technique in plastic surgery. claimed to be safe soft-tissue filler without foreign body reaction. This article reports on several cases of periorbital lipogranuloma after autologous for facial augmentation. <h3>Methods</h3> was retrospective, non-comparative and interventional case series. The authors identified nine patients with lipogranuloma. All had history previous by different surgeons. A medical record...
Despite extensive efforts on the genomic characterization of gliomas, very few studies have reported genetic alterations cerebellar glioblastoma (C-GBM), a rare and lethal disease. Here, we provide systematic study C-GBM to better understand its specific features.We collected cohort patients compared patient demographics tumor pathologies with supratentorial (S-GBM). To uncover molecular characteristics, performed DNA mRNA sequencing methylation arrays 19, 6, 4 cases, respectively. Moreover,...
Clinicopathological features of four cases oncocytic adrenocortical carcinomas were studied. All tumors large, circumscribed with average size and weight 11.5 cm 586 g, respectively. The cut surfaces yellow or brown tan areas hemorrhage, necrosis, fibrosis, myxoid cystic change. tumor cells exclusively a diffuse compact solid arrangement. Nuclear atypia was identified but mitosis rare. Capsular invasion in all vascular one tumor. immunoreactive for vimentin inhibins. Immunoreactivity...
<b>BACKGROUND AND PURPOSE:</b> A cavernous angioma is a developmental vascular malformation with high risk of hemorrhage. The purpose this work was to retrospectively determine whether an MR sign T1 hyperintense perilesional signal intensity useful for the differentiation from other hemorrhagic cerebral masses. <b>MATERIALS METHODS:</b> institutional review board approved study. We evaluated images 72 patients acute or subacute lesions edema (29 angiomas, 13 glioblastomas, 1...
The mechanism of mouse parturition is thought to involve myometrial infiltration by amniotic fluid (AF) macrophages, activated surfactant protein-A (SP-A). In humans, the concentration AF SP-A decreases during labor, and no fetal macrophages are found in myometrium after labor. Therefore, it appears that mechanisms labor mice humans different. We investigated a potential role for human pregnancy examining expression patterns amnion. High molecular mass (>250 kDa) oligomeric was increased...
We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB).From October 2005 through September 2010, twenty consecutive aged >3 years MB (presence metastasis and/or postoperative residual tumor >1.5 cm(2)) were assigned to receive 2 cycles pre-RT...