A5046774061- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Moyamoya disease diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cerebrospinal fluid and hydrocephalus
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Adipose Tissue and Metabolism
- Fluid Dynamics and Thin Films
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Spinal Dysraphism and Malformations
- Ferroptosis and cancer prognosis
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- High-Temperature Coating Behaviors
- Neuroblastoma Research and Treatments
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
CHA Bundang Medical Center
2021-2023
CHA University
2021-2023
Dankook University Hospital
2021
Korea University
2015-2020
Catholic Kwandong University
2017-2020
Seoul National University
2007-2018
Gwangju Institute of Science and Technology
2018
Seoul National University Children's Hospital
2013-2017
Abstract Advanced metastatic cancer poses utmost clinical challenges and may present molecular cellular features distinct from an early-stage cancer. Herein, we single-cell transcriptome profiling of lung adenocarcinoma, the most prevalent histological type diagnosed at stage IV in over 40% all cases. From 208,506 cells populating normal tissues or early to 44 patients, identify a cell subtype deviating differentiation trajectory dominating stage. In stages, stromal immune dynamics reveal...
Leptomeningeal metastases (LMs) exhibit a high incidence in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) post-treatment first- or second-generation EGFR tyrosine kinase inhibitors (TKIs). This investigation evaluates the efficacy, safety, and pharmacokinetics of 80 mg once daily osimertinib LMs resistant to prior TKIs.
Tumors involving Meckel's cave remain extremely challenging because of the surrounding complex neurovascular structures and deep-seated location. The authors investigated a new minimal-access technique using endoscopic transorbital approach (eTOA) through superior eyelid crease to middle cranial fossa lesions reviewed most useful surgical procedures pitfalls this approach.
Lupus erythematosus panniculitis (LEP) is an inflammatory disorder of the subcutaneous fat in patients with lupus (LE). It a rare variant disease, which occurs approximately 1%-3% cutaneous LE. The purpose this study was to investigate clinical, histopathologic, immunophenotypical, and molecular profiles LEP. We performed retrospective 19 biopsy specimens from 17 reviewed their clinical data reexamined histopathology. Immunophenotyping studies were done using sections paraffin-embedded...
Cranioorbital tumors are complex lesions that involve the deep orbit, floor of frontal bone, and lesser greater wing sphenoid bone. The purpose this study was to describe clinical ophthalmological outcomes with an endoscopic transorbital approach (TOA) in management cranioorbital involving orbit intracranial compartment.
Background and Purpose— In pediatric moyamoya disease, there are few reports on the efficacy of surgical intervention for stroke prevention. We evaluated long-term outcomes indirect bypass surgery a relatively large number children with disease in single center. Methods— From August 1988 to December 2012, 772 underwent surgery. This study included 629 patients who were followed up >5 years, excluding syndrome. The mean clinical follow-up duration was 12 years (range, 5–29 years)....
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor with few treatment options. The survival of glioma-initiating cells (GICs) one major factors contributing to failure. GICs frequently produce and respond their own growth that support cell proliferation survival. In this study, we aimed identify critical autocrine mediating GIC evaluate anti-GBM effect antagonizing these factors. Proteomic analysis was performed using conditioned media from two different patient-derived GBM...
Atypical teratoid/rhabdoid tumors (AT/RT) are among the most malignant pediatric brain tumors. Cells from with high aldehyde dehydrogenase (ALDH) activity have a number of characteristics that similar to tumor initiating cells (BTICs). This study aimed evaluate therapeutic potential ALDH inhibition using disulfiram (DSF) against BTICs AT/RT. Primary cultured AT/RT were stained Aldefluor and isolated by fluorescence activated cell sorting. The effect DSF was confirmed in vitro vivo. displayed...
AbstractBackground: Although systemic cyclosporine appears to be one of the treatment options for chronic severe alopecia areata (AA), high recurrence rates after discontinuation and side effects make a nominal agent AA. Objective: This study was designed determine whether combination therapy methylprednisolone could an effective Methods: A total 46 patients with AA were treated (200 mg twice daily, two 100 tablets) (24 daily men, 20 women, 12 children). The doses diminished by 4 mg/day...
The authors performed morphological and functional studies of the mitochondria in particular blood cells, i.e., endothelial colony-forming cells (ECFCs), from patients with moyamoya disease. results indicated that these ECFCs exhibit abnormalities, which may present new insights into pathogenesis
The petrous apex (PA) is one of the most challenging areas in skull base surgery because it surrounded by numerous critical neurovascular structures. authors analyzed clinical outcomes patients who underwent endoscopic endonasal approach (EEA) and transorbital (TOA) procedures for lesions involving PA to determine perspectives proper applications these two approaches.The included younger than 80 years with were treated between May 2015 December 2019 had regular follow-up MR images available...
Neurofibromatosis Type 2 (NF2) is an autosomal-dominant inherited disease, characterized by multiple neoplasia syndromes, including meningioma, schwannoma, glioma, and ependymoma. In this report, the authors present their clinical experience with pediatric NF2 patients. particular, they focused on course of vestibular schwannoma (VS), natural growth rate, tumor control, functional hearing outcomes.From May 1988 to June 2012, recruited patients who were younger than 18 years fulfilled...
OBJECTIVE In a minority of patients with neurofibromatosis Type 1 (NF-1), cerebral vasculopathy reminiscent moyamoya disease develops. This phenomenon is called syndrome (MMS), but there are no known risk factors for the prediction MMS in NF-1 patients. Polymorphism RNF213 gene has exhibited strong associations familial and sporadic other vasculopathies. The aim this study to find whether c.14576G>A variant associated development population or not. METHODS group included 16 documented MMS....
Recent studies have shown that several upstream signaling elements of apoptosis and necroptosis are closely associated with acute injury in the heart. In our study, we observed miR-105 was notably dysregulated rat hearts myocardial infarction (MI). Thus, purpose this study to test hypothesis participates regulation RIP3/p-MLKL- BNIP3-dependent necroptosis/apoptosis H9c2 cells MI hearts. Our results show RIP3/p-MLKL necroptotic pathway enhanced under hypoxic conditions, whereas, compared...
Abstract Background Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are infirmity, vascular disease, and adverse cardiovascular risk factors. Currently, female sexual considered neuroprotective agents. The purpose this study was to assess the role sex ratio estradiol/testosterone (E/T) in patients acute (AIS). Methods Between January 2011 December 2016, 146 male AIS 152 age-...