A5091537747- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Advanced MIMO Systems Optimization
- Radiomics and Machine Learning in Medical Imaging
- Advanced Wireless Communication Techniques
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Wireless Communication Networks Research
- Osteoarthritis Treatment and Mechanisms
- Antenna Design and Optimization
- Advanced Adaptive Filtering Techniques
- Colorectal Cancer Treatments and Studies
- Vasculitis and related conditions
- PI3K/AKT/mTOR signaling in cancer
- Single-cell and spatial transcriptomics
- Antenna Design and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- CNS Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cooperative Communication and Network Coding
- Phenothiazines and Benzothiazines Synthesis and Activities
- Meningioma and schwannoma management
- Chemical Synthesis and Analysis
- Inflammatory mediators and NSAID effects
Sungkyunkwan University
2015-2023
Samsung Medical Center
2015-2023
Columbia University
2023
Seoul National University Hospital
2021
Yonsei University
2000-2021
Chungnam National University Hospital
2018
Samsung (South Korea)
2014-2017
Inje University Sanggye Paik Hospital
2017
Wonkwang University
2017
Hanyang University
2003-2014
To identify the incidence and risk factors of emergence agitation in adults undergoing general anesthesia for nasal surgery.We retrospectively examined 792 patients aged ≥18 years who underwent elective surgery between July 2012 August 2013. Patients postanesthesia care unit with a Richmond Agitation Sedation Scale≥+1 at any time were considered to have agitation.The overall is 22.2%. From multivariate regression analysis, following six variables found be significantly associated (P<0.05):...
Targeted disruption of STAT3 function has proven to be a useful cancer therapeutic approach by inducing apoptotic cell death. Cucurbitacin is currently under development as small molecule inhibitor trigger death in many cancers. Here, we systematically studied the molecular mechanisms underlying cucurbitacin-induced death, particular involvement autophagy. Treatment with cucurbitacin resulted non-apoptotic caspase-independent manner. Notably, enhanced excessive conversion lipidated LC3...
Abstract Background Although temozolomide (TMZ) has been used as a standard adjuvant chemotherapeutic agent for primary glioblastoma (GBM), treating isocitrate dehydrogenase wild-type (IDH-wt) cases remains challenging due to intrinsic and acquired drug resistance. Therefore, elucidation of the molecular mechanisms TMZ resistance is critical its precision application. Methods We stratified 69 IDH-wt GBM patients into TMZ-resistant ( n = 29) sensitive 40) groups, using screening corresponding...
Abstract Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and cells metastasize to distant organs via blood vessels. However, whether invasion vessels remains unknown. As glioblastoma (GBM) featured by aggressive vascular abnormalities, we characterized onset of remodeling in diffuse infiltrating zone establishing new spontaneous GBM models robust capacity. Normal brain underwent a gradual transition severely impaired at periphery...
A perioperative intravenous lidocaine infusion has been reported to decrease postoperative pain. The goal of this study was evaluate the effectiveness in reducing pain for laparoscopic colectomy patients. Fifty-five patients scheduled an elective were randomly assigned 2 groups. Group L received bolus injection 1.5 mg/kg before intubation, followed by mg/kg/h continuous during operation. C same dosage saline at time. Postoperative assessed 2, 4, 8, 12, 24, and 48 hours after surgery using...
We aimed to evaluate the potential of radiomics as an imaging biomarker for glioblastoma (GBM) patients and explore molecular rationale behind using a radio-genomics approach. A total 144 primary GBM were included in this study (training cohort). Using multi-parametric MR images, features extracted from multi-habitats tumor. applied Cox-LASSO algorithm build survival prediction model, which we validated independent validation cohort. consensus clustered reveal inherent phenotypic subtypes....
Abstract Background We evaluated the therapeutic efficacy of GC1118, a novel anti‐epidermal growth factor receptor (EGFR) monoclonal antibody, in recurrent glioblastoma (GBM) patients with EGFR amplification. Methods This study was multicenter, open‐label, single‐arm phase II trial. Recurrent GBM amplification were eligible: determined using fluorescence situ hybridization analysis when sample had both EGFR/CEP7 ratio ≥2 and tight cluster signal ≥10% recorded cells. GC1118 administered...
Abstract PTEN is one of the most frequently altered tumor suppressor genes in malignant tumors. The dominant-negative effect alteration suggests that aberrant function mutation might be more disastrous than deletion, frequent genomic event glioblastoma (GBM). This study aimed to understand functional properties various missense mutations and investigate their clinical relevance. landscape was analyzed using Samsung Medical Center GBM cohort validated via Cancer Genome Atlas dataset. Several...
We introduce a simple adaptive procedure for computing the suboptimal weight vector of an array system operating at cell-site. The total computational load primary eigenvector generalized eigen-problem is only O(8.5N) including matrices updates. performance provided by proposed beamformer shown in 3 typical cases multipath fading wideband CDMA channel.
Hypermutagenesis refers to marked increase in the number of mutations due continuous mutagenic process. Hypermutated tumors, have being found several tumor types, are associated with inherited or acquired alterations DNA repair pathways. Hypermutation has been observed a subset adult glioma patients as direct result temozolomide(TMZ)-induced mutagenesis. In our study, we identified rare treatment-naïve gliomas de novo hypermutator phenotype and explored evolution spontaneous...
Targeted next-generation sequencing (NGS) panels for solid tumors have been useful in clinical framework accurate tumor diagnosis and identifying essential molecular aberrations. However, most cancer designed to address a wide spectrum of pan-cancer models, lacking integral prognostic markers that are highly specific gliomas.To such challenges, we developed glioma-specific NGS panel, termed "GliomaSCAN," is capable capturing single nucleotide variations insertion/deletion, copy number...
The prognostic roles of clinical and laboratory markers have been exploited to model risk in patients with primary CNS lymphoma, but these approaches do not fully explain the observed variation outcome. To date, neuroimaging or molecular information is used. aim this study was determine utility radiomic features capture clinically relevant phenotypes, link those profiles for enhanced stratification.
We report a case of 72-year-old woman with Churg-Strauss syndrome, who presented intestinal perforation. She has had bronchial asthma peripheral blood eosinophilia for 30 years. Gross findings resected colon showed multiple ulcers Histologic demonstrated transmural inflammation infiltrated large numbers eosionophils, neutrophils and lymphoplasma cells, characteristic extravascular granuloma in the subserosa. There were multifocally-distributed vasculitis showing all stages activity medium...
We aimed to evaluate the preclinical efficacy of GC1118, a novel anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), against glioblastoma (GBM) tumors using patient-derived xenograft (PDX) models. A total 15 distinct GBM PDX models were used therapeutic GC1118. Genomic data derived from analyzed identify potential biomarkers associated with anti-tumor cell-based high-throughput drug screening assay was performed further validate Compared cetuximab, GC1118 exerted...
In this letter, the joint optimization of a source-relay pair is proposed for multiple-input multiple-output (MIMO) two-way relay networks. these networks, since beamformer design problem based on minimum mean square error (MMSE) known to be non-convex, it cannot solved analytically. order solve problem, novel iterative algorithm that uses duality relationships. First, MSE MIMO networks presented; then, applied method, which provides closed-form solutions all subproblems. Because does not...
Abstract Glioblastomas are among the most fatal brain tumors. Although no effective treatment option is available for recurrent glioblastomas ( GBM s), a subset of patients evidently derived clinical benefit from bevacizumab, monoclonal antibody against vascular endothelial growth factor. We retrospectively reviewed with who received bevacizumab to identify biomarkers predicting response bevacizumab. Following defined criteria, were categorized into two groups, and their genetic...
Aortic dissection during pregnancy is a devastating event for both the pregnant woman and baby. We report case of acute aortic (Stanford type A) in with Marfan syndrome at 29(th) week gestation. She underwent cesarean section followed by an ascending aorta total arch replacement cardiopulmonary bypass, without prior sternotomy. The hemodynamic parameters were kept stable using inotropes vasopressors under transesophageal echocardiography monitoring. newborn survived after endotracheal...
A current-mode differential signaling of three data over two pairs transmission lines increases the effective maximum rate per pair by about 37% conventional pure signaling. Each is transmitted as a half-swing signal lines. The third complementary common-mode Both single-tap pre-emphasis and decision feedback equalizer are combined with this work. Adding D flip-flop between amplifier MUX embedded receiver enables 4-Gb/s operation receiver. chip fabricated using 0.25-/spl mu/m CMOS process...
Abstract Glioblastoma (GBM) is the most malignant primary brain tumor in adults with substantial genomic alterations. The median survival approximately 14.6 months, despite aggressive therapeutic intervention, which comprised of surgical resection, radiotherapy, and chemotherapy. Recent studies on cancer have revealed crucial insights into dynamic molecular subgroups within GBM, govern distinct clinical response sensitivity each individual to therapy. In present study, we analyzed...