A5100766109- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Glioma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Urinary Bladder and Prostate Research
- Brain Metastases and Treatment
- Urinary Tract Infections Management
- Cancer Immunotherapy and Biomarkers
- Pelvic floor disorders treatments
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Urologic and reproductive health conditions
- PI3K/AKT/mTOR signaling in cancer
- Biological Research and Disease Studies
- Cancer, Hypoxia, and Metabolism
- Surgical Simulation and Training
- Cancer Research and Treatments
- Ureteral procedures and complications
Keimyung University
2025
Sungkyunkwan University
2012-2024
Samsung Medical Center
2011-2024
National Cancer Center
2022-2023
Korea Institute of Oriental Medicine
2023
Yonsei University
2020
Samsung (South Korea)
2019
Kyungpook National University
2014-2016
Seoul National University
2013
Korea Research Institute of Chemical Technology
2013
Abstract Background Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via evolution. It may be possible overcome treatment resistance by developing a personalized approach against relapsing cancers based on comprehensive analysis of cell type-specific transcriptomic changes over clinical course disease using single-cell RNA sequencing (scRNA-seq). Methods Here, we used scRNA-seq depict landscape single case...
Metastatic relapse of primary lung cancer leads to therapeutic resistance and unfavorable clinical prognosis; therefore, identification key molecules associated with metastatic conversion has significant implications. We previously identified a link between early brain metastasis adenocarcinoma amplification the α-smooth muscle actin (ACTA2) gene. The aim present study was investigate prognostic functional significance ACTA2 expression in cells for potential adenocarcinomas.ACTA2 analyzed...
Abstract Background Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated treatment resistance, unfavorable prognosis, infiltration of pro-tumorigenic macrophages. Results We explore regulatory networks mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive malignant phenotypic...
// Da Eun Jeong 1, * , Hye Jin Song 2, Sharon Lim 3 Se Lee 4 Joung 5 Do-Hyun Nam 4, 6 Kyeung Min Joo 2 Byong Chang Seong Soo Jeon Han Yong Choi Won 7 1 Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea Anatomy Cell Biology, Samsung Medical Center, University School Medicine, Pathology Translational Genomics, Institute for Refractory Cancer Research, Urology, Neurosurgery, Research Future These authors have contributed equally to this work...
Abstract Purpose: The increasing prevalence of distant metastases from non–small cell lung cancer (NSCLC) indicates an urgent need for novel therapeutic modalities. Brain metastasis is particularly common in NSCLC, with severe adverse effects on clinical prognosis. Although the molecular heterogeneity NSCLC and availability various targeted agents suggest personalized approaches such brain metastases, further development appropriate preclinical models needed to validate strategies....
Objectives To determine the effect of visceral obesity on prognosis advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed clinicopathological data 2187 who underwent nephrectomy for (localized [T1–2, N0, M0], n = 1738 [79.5%]; [T3–4, any N and M], 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The fat area subcutaneous were determined level umbilicus computed tomograms obtained before surgery. Patients categorized as either viscerally obese or non‐obese...
Abstract Non‐small cell lung carcinoma (NSCLC), which affects the brain, is fatal and resistant to anti‐cancer therapies. Despite innate, distinct characteristics of brain from other organs, underlying delicate crosstalk between metastatic NSCLC (BM‐NSCLC) cells tumor microenvironment (bTME) associated with evolution remains elusive. Here, a novel 3D microfluidic tri‐culture platform proposed for recapitulating positive feedback BM‐NSCLC astrocytes brain‐specific endothelial cells, two major...
Radical prostatectomy (RP) is the main treatment of prostate cancer (PCa). Biochemical recurrence (BCR) following RP remains first sign aggressive disease; hence, better assessment potential long-term post-RP BCR-free survival crucial. Our study aimed to evaluate a combined clinical-deep learning (DL) model using multiparametric magnetic resonance imaging (mpMRI) for predicting in PCa. A total 437 patients with PCa who underwent mpMRI followed by between 2008 and 2009 were enrolled;...
Abstract Background Although temozolomide (TMZ) has been used as a standard adjuvant chemotherapeutic agent for primary glioblastoma (GBM), treating isocitrate dehydrogenase wild-type (IDH-wt) cases remains challenging due to intrinsic and acquired drug resistance. Therefore, elucidation of the molecular mechanisms TMZ resistance is critical its precision application. Methods We stratified 69 IDH-wt GBM patients into TMZ-resistant ( n = 29) sensitive 40) groups, using screening corresponding...
Elevated lipid metabolism promotes cancer cell proliferation. Clear renal carcinoma (ccRCC) is the most common subtype of kidney cancers, characterized by ectopic accumulation. However, relationship between aberrant and tumorigenesis in ccRCC not thoroughly understood. Here, we demonstrate that ring finger protein 20 (RNF20) acts as a tumor suppressor ccRCC. RNF20 overexpression repressed lipogenesis proliferation inhibiting sterol regulatory element-binding 1c (SREBP1c), SREBP1 suppression,...
Abstract Brain metastasis is the most common type of intracranial cancer and main cause cancer-associated mortality. mainly originates from lung cancer. Using a previously established in vitro brain metastatic model, we found that PC14PE6/LvBr4 cells exhibited higher expression β-catenin increased migratory activity than parental PC14PE6 cells. Knockdown dramatically suppressed motility invasiveness cells, indicating involved controlling potential. Since protein was without significant...
Acquired paclitaxel (PTX) resistance limits its effectiveness and results in advanced cancer progression. This review investigated whether the inhibition of phosphatidylinositol 3-kinase (PI3K) signaling overcomes cervical cancer. It was established paclitaxel-resistant cell lines (PTX-R ME180/PTX-R HeLa) determined combination index for PI3K inhibitors (BYL-719/ LY294002) by tetrazolium dye assay. Flow cytometry used to detect cycle apoptosis. Migration invasion were explored wound healing...
Abstract We compared the progression patterns after radical nephroureterectomy (RNU) and elective distal ureterectomy (DU) in patients with urothelial carcinoma of ureter. Between Jan 2011 Dec 2020, 127 who underwent RNU 46 DU for ureteral cancer were enrolled this study. The upper tract recurrence between two groups. Progression was defined as a local and/or distant metastasis surgery. Upper subsequent treatment analyzed. occurred 35 (27.6%) 10 (21.7%) groups, respectively. pattern not...
Abstract Background Cholestatic liver disease, characterized by impaired bile flow, leads to the accumulation of harmful metabolites and toxins, resulting in damage. Inflammatory cytokines are crucial for progression this condition. Clusterin is a glycoprotein with roles cell death, lipid transport, cellular protection. We previously demonstrated that clusterin protects against hepatic steatosis fibrosis. This study explored cholestatic injury induced DDC...
This study aimed to evaluate the antioxidant activities of Tenebrio molitor L. (TM) and Protaetia brevitarsis seulensis (PB). Water extracts TM PB were prepared at concentrations 2, 4, 6, 8, 10, 20, 40, 60, 80, 100 mg/mL. Cell viability assays performed cytoprotective effects water extracts. Antioxidant measured using ABTS DPPH radical scavenging reducing power. The cell significantly increased in a dose-dependent manner, with exhibiting superior efficacy compared PB. exhibited high...
To directly compare the outcome of laparoscopic radical prostatectomy (LRP) with robot-assisted (RALP) performed by a single surgeon intermediate experience-one who is between novice and an expert.Consecutive 106 patients prostate cancer were treated (62 LRP 44 RALP) included. The preoperative characteristics, perioperative surgical outcomes, functional outcomes compared two groups.The mean operative time was longer in RALP group (371 min vs 308 min, P = 0.00), conceivably because more...
Glioblastoma multiforme (GBM) is clinically highly aggressive as a result of evolutionary dynamics induced by cross-talk between cancer cells and heterogeneous group immune in tumor microenvironment. The brain harbors limited numbers with few lymphocytes macrophages; thus, innate-like lymphocytes, such γδ T cells, have important roles antitumor immunity. Here, we characterized GBM-infiltrating which may regulating the GBM microenvironment cell gene expression. V(D)J repertoires...