A5059649335- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Urologic and reproductive health conditions
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Ferroptosis and cancer prognosis
- Urinary Bladder and Prostate Research
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Kidney Stones and Urolithiasis Treatments
- Radiomics and Machine Learning in Medical Imaging
- Hormonal and reproductive studies
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
Seoul National University Hospital
2016-2025
Seoul National University
2016-2025
NYU Langone Health
2025
New York University
2025
Catholic University of Daegu
2015-2024
New Generation University College
2005-2023
Yonsei University
2022-2023
National University College
2023
Memorial Sloan Kettering Cancer Center
2021
Yeungnam University
2017-2021
Importance An accurate noninvasive biomarker test is needed for the early diagnosis of bladder cancer. Objective To evaluate performance a urinary DNA methylation ( PENK methylation) and compare its diagnostic accuracy with that nuclear matrix protein 22 (NMP22) or urine cytology test. Design, Setting, Participants In this prospective multicenter study at 10 sites in Republic Korea, individuals 40 years older hematuria undergoing cystoscopy within 3 months between March 11, 2022, May 30,...
Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate adenocarcinoma (AdPC) cells and acts as a target for molecular imaging. However, some case reports indicate that PSMA-targeted imaging could be ineffectual delineation of neuroendocrine (NE) cancer (NEPC) lesions due to the suppression PSMA gene (FOLH1). These same suggest targeting somatostatin receptor type 2 (SSTR2) an alternative diagnostic NEPC patients. This study evaluates correlation between expression FOLH1,...
Extracting valuable information from the overflowing data is a critical yet challenging task. Dealing with high volumes of biometric data, which are often unstructured, nonstatic, and ambiguous, requires extensive computer resources specialists. Emerging neuromorphic computing technologies that mimic processing properties biological neural networks offer promising solution for handling data. Here, development an electrolyte-gated organic transistor featuring selective transition short-term...
To evaluate the associations of preoperative De Ritis ratio (aspartate transaminase [AST]/alanine [ALT]) with postoperative clinical outcomes after surgical treatment localized RCC.We retrospectively reviewed data from 2 965 patients surgically treated for non-metastatic RCC. Propensity scores high AST/ALT were calculated and 430 a matched to 1 117 low ratio. The association between was tested. Multivariate Cox analyses performed identify independent predictors progression-free (PFS),...
Although the incidence of de novo neuroendocrine prostate cancer (PC) is rare, recent data suggest that low expression prostate-specific membrane antigen (PSMA) associated with a spectrum hallmarks and androgen receptor (AR) suppression in PC. Previous clinical reports indicate PCs phenotype similar to tumors can be more amenable imaging by <sup>18</sup>F-FDG than PSMA-targeting radioligands. In this study, we evaluated association between gene signature uptake–associated genes including...
We determine whether the nadir prostate specific antigen (PSA) level after hormone therapy can be used to predict progression refractory cancer.We reviewed progressive status and survival of 177 patients with stage C or D cancer who had received at our institution. The overall rate, incidence interval until were analyzed reference PSA level. Multiple regression analysis was analyze predictive factors for cancer, relative efficacy in predicting evaluated by receiver operating characteristics...
No AccessJournal of UrologyCLINICAL UROLOGY: ORIGINAL ARTICLES1 Sep 2002Prognostic Significance The Nadir Prostate Specific Antigen Level After Hormone Therapy for Cancer Cheol Kwak, Seong Jin Jeong, Moon Soo Park, Eunsik Lee, and Sang Eun Lee KwakCheol Kwak More articles by this author , JeongSeong Jeong ParkMoon Park LeeEunsik LeeSang View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64559-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? Late recurrence more than five years after initial treatment is one biological behaviours specific for RCC. In our study, late was observed in 8.8% patients. Also, patients with had favorable clinicopathological features better prognosis long cancer‐specific survival recurrence. Age preoperative hs‐CRP levels may be independent predictive factors OBJECTIVE To evaluate renal cell...
Systemic inflammatory response (SIR) is important in the relationship between tumour, host, and outcome cancer patients. However, limited data exist regarding prognostic significance of SIR bladder cancer. We investigate utility pretreatment patients with urothelial carcinoma undergoing radical cystectomy.The study cohort consisted 419 a median follow-up 37.7 months. The SIRs used for each described nomogram are consistent previously published data: C-reactive protein, albumin, white cell...
The prognostic role of systemic inflammatory response (SIR) markers is unclear in patients with non-muscle invasive bladder cancer (NMIBC). Here, we aimed to investigate the various SIR oncological outcomes (NMIBC) at a single institution Korea. Neutrophil-lymphocyte ratio (NLR), derived-NLR (dNLR), and platelet-lymphocyte (PLR) were examined as markers. We retrospectively collected data 1,698 NMIBC who underwent transurethral resection (TURB) between 1990 2013. After excluding 147 patients,...
The study evaluated whether preoperative measures of the C-reactive protein-systemic inflammatory response may predict cancer survival independent tumor stage in patients with upper urinary tract urothelial carcinoma (UTUC).Between September 1999 and October 2010, 181 submitted to radical nephroureterectomy were available for evaluation. Multivariate analyses performed using Cox's proportional hazards model coefficient each factor was divided by highest coefficient, multiplied 4, rounded...
Abstract The World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading renal cell carcinoma (RCC) is classified from grade 1–4, regardless subtype. National Comprehensive Cancer Network (NCCN) guidelines (2022) state that if there an adverse pathological feature, such as 3 or higher RCC in stage 1 patients, more rigorous follow-up imaging recommended. However, the do not provide specific treatment policies by tumor grade. Therefore, this study attempted to...
OBJECTIVE To compare patients with and no stenting after ureteroscopy for ureteric calculi, as placing such stents is routine, although many complain of pain urinary symptoms. PATIENTS AND METHODS In all, 45 calculi amenable to ureteroscopic management were prospectively randomized into a stented (23) or an unstented (22) group. Standard basketing lithotripsy was used, through ureteroscope (8.5 F) without dilatation. Symptom questionnaires completed by the treatment, they followed...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2004Expression Survivin, a Novel Inhibitor Apoptosis, in Superficial Transitional Cell Carcinoma the Bladder J.A. HYEON KU, CHEOL KWAK, HYE SUN LEE, HYOUNG KEUN PARK, EUNSIK and SANG EUN LEE KUJ.A. KU , KWAKCHEOL KWAK LEEHYE PARKHYOUNG PARK LEEEUNSIK LEESANG View All Author Informationhttps://doi.org/10.1097/01.ju.0000106082.44786.3bAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
The aim of this study was to describe the surgical clip-related complications that can occur after open retropubic prostatectomy (RRP), pure laparoscopic (LRP), and robot-assisted radical (RALP).A database 641 patients who underwent RRP (n=439), LRP (n=49), RALP (n=153) at our institution between January 2006 April 2009 reviewed identify with related use clips. median follow-up time for entire cohort 19.0 months (range, 1-42 months).Of patients, 25 (5.7%), 1 (2.0%), 2 (1.3%) had a bladder...
Prostate cancer can be controlled by androgen‐hormone treatment until the becomes refractory. It is believed that hormone sensitivity largely dependent on androgen receptor (AR) activity. Here, we found histone demethylase KDM7A which demethylates H3K27 to overexpressed in enzalutamide resistant castration‐resistant prostate cell line C4‐2b, and investigated molecular mechanism whereby activity regulated KDM7A. We engineered AR‐positive LNCaP cells stably express a short‐hairpin RNA against...