A5074586905- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Cannabis and Cannabinoid Research
- Luminescence and Fluorescent Materials
- Ionic liquids properties and applications
- Carbohydrate Chemistry and Synthesis
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Mass Spectrometry Techniques and Applications
- Prostate Cancer Treatment and Research
- Analytical Chemistry and Chromatography
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Boron and Carbon Nanomaterials Research
- RNA Research and Splicing
- Protein Structure and Dynamics
- Immune Cell Function and Interaction
- Enzyme Catalysis and Immobilization
University of Windsor
2017-2025
WE-SPARK Health Institute
2023-2024
PROTO Manufacturing (Canada)
2024
Spark Therapeutics (United States)
2023
Kochi University of Technology
2022
University of Rajasthan
2022
Université Grenoble Alpes
2022
Kyushu University
2022
St Petersburg University
2022
St. Petersburg State Technological Institute
2022
Engineered hydrogels have been extensively used to direct cell function in 3D culture models, which are more representative of the native cellular microenvironment than conventional 2D culture. Previously, hyaluronan-furan and bis-maleimide polyethylene glycol were synthesized via Diels–Alder chemistry at acidic pH, did not allow encapsulation viable cells. In order enable gelation physiological reaction kinetics accelerated by replacing with electron-rich hyaluronan-methylfuran. These new...
Self-immolative polymers, which degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from polymer terminus, are increasing interest for wide variety applications ranging sensors controlled release. However, preparation these materials often requires expensive, multistep monomer syntheses, and degradation products such as quinone methides or phthalaldehydes potentially toxic humans environment. We demonstrate here that polyglyxoylates can...
Abstract There is currently an urgent need for the development of new antibacterial agents to combat spread antibiotic‐resistant bacteria. We explored synthesis and activities novel, sugar‐functionalized phosphonium polymers. While these compounds exhibited activity, we unexpectedly found that control polymer poly(tris(hydroxypropyl)vinylbenzylphosphonium chloride) showed very high activity against both Gram‐negative Escherichia coli Gram‐positive Staphylococcus aureus low haemolytic red...
Although the incidence of de novo neuroendocrine prostate cancer (PC) is rare, recent data suggest that low expression prostate-specific membrane antigen (PSMA) associated with a spectrum hallmarks and androgen receptor (AR) suppression in PC. Previous clinical reports indicate PCs phenotype similar to tumors can be more amenable imaging by <sup>18</sup>F-FDG than PSMA-targeting radioligands. In this study, we evaluated association between gene signature uptake–associated genes including...
Polymers that undergo end-to-end depolymerization in response to the cleavage of a stimuli-responsive end-cap are promising for diverse applications from drug delivery responsive coatings and plastics. It is critical designed respond an appropriate stimulus application. In current work, end-caps triggering poly(ethyl glyoxylate) (PEtG) were explored. First, phenylboronate, disulfide, azobenzene utilized impart redox-responsive properties PEtG. Then, methoxy-substituted trityl groups used...
Pyrophosphate (PPi) is a byproduct of DNA and RNA synthesis, abnormal levels are indicative disease. We report the high-affinity binding PPi in water by N-alkyl ammonium resorcinarene chloride receptors. Experimental analysis using 1H 31P NMR, isothermal titration calorimetry, mass spectrometry, UV-vis spectroscopy all support exceptional selectivity these systems for water. The measured affinity K1 = 1.60 × 107 M-1 three orders magnitude larger than that observed to another phosphate, ATP....
Abstract The limited diversity in targets of available antibiotic therapies has put tremendous pressure on the treatment bacterial pathogens, where numerous resistance mechanisms that counteract their function are becoming increasingly prevalent. Here, we utilize an unconventional anti-virulence screen host-guest interacting macrocycles, and identify a water-soluble synthetic macrocycle, Pillar[5]arene, is non-bactericidal/bacteriostatic mechanism action involves binding to both homoserine...
A new thermo-responsive end-cap was developed and applied to self-immolative vesicles micelles with both direct indirect thermal triggering.
Calcium-ion batteries show promise as high-density, next-generation replacements for current lithium-ion batteries. The precise chemical structure of the carbonate electrolyte solvent has a large impact on calcium battery efficacy. In this computational study, we have investigated solvation behavior tetrafluoroborate in both neat carbonates and mixtures using combined molecular dynamics simulations quantum mechanical calculations. Our results indicate that ethyl methyl mixture ethylene...
Magnetite (Fe3O4) nanoparticles, are promising inorganic nanomaterials for future biomedical applications due to their low toxicity and unique magnetic properties. However, the synthesis of these particles can often be expensive, energy intensive, non-scalable, requiring addition surfactants stabilize material control particle size avoid agglomeration. We wish report a simple, green, surfactant-free electrochemical materials using closed aqueous system at ambient temperature. Particle...
The depolymerization of coatings prepared from a 6-nitroveratryl carbonate end-capped poly(ethyl glyoxylate) (PEtG) self-immolative polymer was studied. This undergoes end-to-end following cleavage the end-cap by UV light. Several important fundamental differences between this class polymers and conventional degradable were revealed. For example, backbone exhibited different dependencies on pH, emphasizing decoupling these processes. Probing coating erosion mechanism illustrated an...
Significance Glutamate-ureido-lysine (GUL) probes are specific for prostate-specific membrane antigen (PSMA), overexpressed by most prostate cancers. This can be lost as the cancer progresses. Recent reports have indicated that GUL still identify these PSMA-negative tumors, indicating expression of alternative PSMA-like proteins may change during disease progression. In this study we identified two such candidate protein targets, NAALADaseL and mGluR8, using a combined computational...
Fluorescent-small molecules offer an excellent source of chemosensors when optimized for detection anions with sensitivity and selectivity, low-cost robust synthesis.
Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. When is non-functional may also be undergoing uncontrolled cell growth (due to other mutations), cancer readily emerges. Consequently, restoring the function misregulated and mutated an incredibly important goal therapeutic oncology. mutations often induce conformational changes inhibit protein’s ability engage its...
Chemistry is a potentially dangerous enterprise. Major incidents in academic and industrial settings are commonly used the form of case studies to suggest lessons inspire change; however, truism safety that major often arise from same causes as those previously caused minor events remained unaddressed. However, make up only very small percentage could, with multiple failures, lead adverse outcomes. In this study, we examined 258 routine reported between 2016 2020 at petrochemical processing...
CB1, a member of the G protein-coupled receptor class, is putative protein target THC, psychoactive component cannabis. To better identify new synthetic cannabinoids with increased activity, all reported experimental binding to CB1 were modelled in silico build predictive model for affinity small molecules. Computationally derived not sufficient and itself predict binding, but coupled evidence that ligands enter from membrane rather than solvent, we provide accurately describes these...
Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. We report a class biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols. A simple pH-assisted coupling protocol was employed synthesize covalent non-covalent conjugates, which were then produce 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) enriched oil nanoemulsions in water an average droplet sizes ca....