A5100337388- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Macrophage Migration Inhibitory Factor
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Cancer Cells and Metastasis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Neurogenesis and neuroplasticity mechanisms
- Smoking Behavior and Cessation
- Blood properties and coagulation
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- Biochemical Analysis and Sensing Techniques
National Cancer Center
2017-2024
Sungkyunkwan University
2021-2022
Abstract The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of multiforme (GBM). However, the detailed molecular mechanisms underlying relationship these two cell types remain unclear. Here, we demonstrate that ARS2 (arsenite-resistance protein 2), a zinc finger is essential for early mammalian development, plays critical roles in GSC maintenance M2-like TAM polarization. directly activates its novel transcriptional target MGLL ,...
Glioblastoma (GBM) cancer stem cells (CSC) are primarily responsible for metastatic dissemination, resistance to therapy, and relapse of GBM, the most common aggressive brain tumor. Development maintenance CSCs require orchestrated metabolic rewiring adaptation a changing microenvironment. Here, we show that cooperative interplay between mitochondrial chaperone TRAP1 major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma (GSC) increases respiratory capacity reduces production reactive...
Abstract Background Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated treatment resistance, unfavorable prognosis, infiltration of pro-tumorigenic macrophages. Results We explore regulatory networks mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive malignant phenotypic...
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance recurrence. Through a cell surface marker screen, we identified CD142 (tissue factor or F3) is robustly induced the senescence-associated β-galactosidase (SA-βGal)-positive cells after irradiation. F3 promotes clonal expansion of irradiated SA-βGal+ orchestrates oncogenic TME...
Abstract Diffuse infiltration is the main reason for therapeutic resistance and recurrence in glioblastoma (GBM). However, potential targeted therapies GBM stem-like cell (GSC) which responsible invasion are limited. Herein, we report Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) a ligand Receptor tyrosine kinase like Orphan 1 (ROR1), as promising target GSC invasion. Using GSC-derived brain tumor model, GSCs were characterized into invasive or non-invasive subtypes, RNA sequencing...
Necrosis is a hallmark of glioblastoma (GBM) and responsible for poor prognosis resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) upregulated in perinecrotic region triggered mesenchymal (MES) transdifferentiation glioma stem cells (GSC) by regulating master transcription factors (TF), such as C/EBPβ, TAZ, STAT3. TGM2 expression was...
Abstract Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets functional downstream networks regulated by that govern pathogenesis may lead improved treatment strategies. In this study, we identified poly(A)-specific ribonuclease (PARN), modulator RNA metabolism, activates EGFR–STAT3 signaling...
<title>Abstract</title> Current treatment strategies for medulloblastoma remain ineffective due to extensive tumor heterogeneity. In this study, we performed integrated multi-omic characterization improve the conventional molecular classification of medulloblastoma, leading identification seven refined distinct subtypes. The SHH group was reclassified into two subgroups, SHHα and SHHβ, while 4 divided three G4α, G4β, G4γ. Group subtypes exhibit neuronal differentiation trajectories: granular...
As the clinical failure of glioblastoma treatment is attributed by multiple components, including myelin-associated infiltration, assessment molecular mechanisms underlying such process and identification infiltrating cells have been primary objectives in research. Here, we adopted radiogenomic analysis to screen for functionally relevant genes that orchestrate glioma cell infiltration through myelin promote aggressiveness. The receptor Nogo ligand (NgR1) was selected as top candidate...
Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, heterogeneity, poor prognoses in association with GBM. Furthermore, GBM subtype transition from proneural to malignant mesenchymal after radiation also accounts high resistance conventional treatments. Here, we demonstrate that inhibition of macrophage migration inhibitory factor (MIF) D-dopachrome tautomerase...
Leucine-rich repeat kinase 2 (LRRK2), a large GTP-regulated serine/threonine kinase, is well-known for its mutations causing late-onset Parkinson's disease. However, the role of LRRK2 in glioblastoma (GBM) carcinogenesis has not yet been fully elucidated. Here, we discovered that was overexpressed 40% GBM patients, according to tissue microarray analysis, and high expression correlated with poor prognosis patients. stemness factors were highly expressed various patient-derived stem cells,...
MicroRNAs (miRNAs) are considered to be strong prognostic markers and key therapeutic targets in human diseases, especially cancer. A sensitive monitoring platform for cancer-associated miRNA (oncomiR) action is needed mechanistic studies, preclinical evaluation, inhibitor screening. In this study, we developed systemically applied a efficient lentivirus-based system oncomiR actions, essentially miR-21. The specificity sensitivity of "miRDREL" against various oncomiRs were validated by...
Abstract Adapted oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle activations are essential tumor microenvironments for abnormal energy consumption to acquire malignancy drug resistance during cancer development progression. To elucidate the molecular mechanism related mitochondrial metabolic dynamics in glioblastoma (GBM), a longitudinal GBM orthotopic mouse model with acquired bevacizumab is established. The proteomic analysis results show that OXPHOS, TCA, calcium...
Introduction Recently, electric cigarettes with liquid (e-liquid) were introduced as an alternative to tobacco smoking. They promoted possible cessation aids and considered be potentially less harmful than traditional tobacco-based cigarettes. However, there is little information on the toxicants present in e-liquids their carcinogenic effects. Methods Western blot analysis was performed identify protein levels of cancer progression related signal transducers. Patient-derived brain tumor...
Abstract A significant hurdle in treating glioblastoma (GBM) is addressing the development of drug resistance. In this study, role Family Sequence Similarity 20, Member C (Fam20C) as a central player bevacizumab resistant GBM mouse model investigated. vivo analyses confirm that Fam20C upregulation accelerates resistance and correlates with tumor progression. Proteomic conditioned media cell lysates subsequent to knockout (KO) cells reveal regulatory both intracellular extracellular aspects...
Abstract Glioblastoma (GBM) is a malignant brain tumor with poor prognosis that easily recurs. The antiangiogenic agent bevacizumab used to treat recurrent GBM. However, GBM treated rebounds due evasive mechanisms induce resistance treatment, such as hypoxia‐inducible factor (HIF) associated pathways. transcription HIFs are oxygen‐dependent and degraded via the ubiquitin‐dependent proteasomal pathway. Therefore, it necessary study HIF‐associated pathways through translational mRNA profiling....
<p>Supplementary Data</p>
<div>Abstract<p>Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets functional downstream networks regulated by that govern pathogenesis may lead improved treatment strategies. In this study, we identified poly(A)-specific ribonuclease (PARN), modulator RNA metabolism, activates...
<div>Abstract<p>Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets functional downstream networks regulated by that govern pathogenesis may lead improved treatment strategies. In this study, we identified poly(A)-specific ribonuclease (PARN), modulator RNA metabolism, activates...
<p>Supplementary Data</p>