A5014162282- Smoking Behavior and Cessation
- Nutrition, Health and Food Behavior
- FOXO transcription factor regulation
- Health and Wellbeing Research
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Acute Ischemic Stroke Management
- Psychosocial Factors Impacting Youth
- Air Quality and Health Impacts
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Nicotinic Acetylcholine Receptors Study
- Artificial Intelligence in Healthcare
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- Biochemical Analysis and Sensing Techniques
- Cancer-related molecular mechanisms research
- Obesity, Physical Activity, Diet
- Consumer Perception and Purchasing Behavior
- PI3K/AKT/mTOR signaling in cancer
- Berberine and alkaloids research
- Colorectal Cancer Screening and Detection
- Sirtuins and Resveratrol in Medicine
- Pediatric health and respiratory diseases
- Health, psychology, and well-being
Seoul National University Hospital
2015-2024
National Cancer Center
2018-2022
Kyung Hee University
2021
National Cancer Center
2021
Seoul National University
2013-2016
Stomach cancer is the second most common in Eastern Asia, accounting for approximately 50% of all new cases stomach worldwide. Our objective was to compare incidence rates Asian Americans Los Angeles with those native Asians assess etiology from 1988 2011. To examine these differences, (Korean, Japanese, Chinese, and Filipino living Angeles, California, USA) (from Korea, Japan, China, Philippines) were selected this study. Using Cancer Incidence Five Continents database, examined. Data...
Purpose We previously reported that forkhead transcription factors of the O class 1 (FOXO1) expression in gastric cancer (GC) was associated with angiogenesis-related molecules. However, there is little experimental evidence for direct role FOXO1 GC. In present study, we investigated effect on tumorigenesis and angiogenesis GC its relationship SIRT1. Materials Methods Stable cell lines (SNU-638 SNU-601) infected a lentivirus containing shRNA were established animal studies as well culture...
Purpose Lapatinib is a candidate drug for treatment of trastuzumab-resistant, human epidermal growth factor receptor 2 (HER2)–positive gastric cancer (GC). Unfortunately, lapatinib resistance renders this ineffective. The present study investigated the implication forkhead box O1 (FOXO1) signaling in acquired HER2-positive GC cells. Materials and Methods Lapatinib-resistant cell lines (SNU-216 LR2-8) were generated vitro by chronic exposure lapatinib-sensitive, SNU-216 cells to lapatinib. LR...
Background: A considerable amount of research has shown that knowledge and appropriate awareness are essential for encouraging positive behaviors promoting health.In Korea, the roles behavioral changes play in prevention cancer have been an important issue since introduction 10 codes 2006.Thus, present study investigated associations tobacco-related with attitudes towards smoking-cessation behaviors.Methods: The analyzed data from 2010 national questionnaire survey (n = 1,006).This evaluated...
Abstract The prevalence of stress and distress has been increasing being important public health issues; nevertheless, few studies have assessed the factors associated at population level. This study identified how they differentially influence distress. A total 35,105 individuals aged 19 years older using nationally representative data from Korea National Health Nutrition Examination Survey (2007–2012) were included in study. Subjects differentiated by gender psychological state (no...
The popularity of heated tobacco products (HTPs) has been growing globally but, limited information exists on use behaviors and its impact control. This study investigates awareness perception HTPs among users whether perceptions are associated with HTP intention to quit.
Perception of harm plays an important role in predicting intention to quit-an integral part the cessation process. on from bamboo waterpipe tobacco was unknown, even predominant this type use. This study investigated effects perceived cigarette and quit among adult male Vietnamese users.From nationally-representative 2015 Global Adult Tobacco Survey, we included 1,351 males (≥ 18 years old) who used cigarettes, waterpipes, or both. Demographic characteristics, use behaviors, use,...
While tobacco control policies have been adopted and enforced, anti-smoking campaigns conducted, the evaluation of their impact on quitting is lacking in Korea. Therefore, effectiveness mass media to encourage use Quitline were evaluated by monitoring call volume Quitline, which has operation since 2006, Korea.Tobacco campaigns, from 1 January 2007 31 December 2016, assessed review government documents history law regulation changes. The corresponding period incoming volumes assesed. average...
FOXO 1, a forkhead box O ( ) transcription factor, and nuclear factor‐κB NF ‐κB) are prognostically significant factors in gastric cancer. As their relationship has been inconsistent depending on the cell type, we aimed to investigate whether 1 is associated with ‐κB p65 (RelA) Immunohistochemistry was performed tissue array slides containing 298 carcinoma specimens. We found that cytoplasmic expression of p inactive form positively correlated RelA (p = 0.024). In addition, expressions were...
Since the molecular mechanism of hypoxic adaptation in cancer cells is cell‐type specific, we investigated whether glycogen synthase kinase‐3β ( GSK ‐3β) activation involved hypoxia‐induced gastric tumor promotion. Stable cell lines SNU ‐638, ‐484, MKN 1, and 45) were cultured under conditions. Cells overexpressing wild‐type ‐3β WT ‐ or kinase‐dead mutant KD generated used for culture animal studies. In experiments, hypoxia decreased cells. Cell viability expressions HIF ‐1α protein VEGF...
Introduction Recently, electric cigarettes with liquid (e-liquid) were introduced as an alternative to tobacco smoking. They promoted possible cessation aids and considered be potentially less harmful than traditional tobacco-based cigarettes. However, there is little information on the toxicants present in e-liquids their carcinogenic effects. Methods Western blot analysis was performed identify protein levels of cancer progression related signal transducers. Patient-derived brain tumor...
Limited information is available concerning the epidemiology of stroke and acute myocardial infarction (AMI) in Republic Korea. This study aimed to develop a national surveillance system monitor incidence AMI using claims data.
1. Song F, Elwell-Sutton T, Naughton F. Impact of the NHS stop smoking services on prevalence in England: a simulation modelling evaluation. Tob Control. 2020;29(2):200-206. doi:10.1136/tobaccocontrol-2018-054879 CrossRef Google Scholar
Background:The association between experience with "National Smoking Cessation Services (NSCS)" and intention to quit was investigated among adult smokers evaluate its effects provide better services.Methods: From the Tillion Internet research panel, 2,000 tobacco users aged 19-65 years old were sampled country representativeness invited participate in an online survey on November 2018.Information general characteristics, smoking behaviors, cessation services, gathered.A Chi-square test...
Gastric cancer, also known as stomach is a cancer which develops from the lining of stomach. Accumulated evidences and epidemiological studies have been indicated that natural products play an important role in gastric prevention treatment, although its mechanism action did not elucidate yet. Particularly, experimental showed displayed protective effect against via numerous molecular mechanisms such suppression cell metastasis, anti-angiogenesis, inhibition proliferation, induction...
The purpose of this study is to investigate the effects consumers’ technological readiness on perceived shopping value and word-of-mouth intention for fashion augmented reality (AR) stores. After female consumers aged 20-40 watched a video consumer trying clothes virtually through smart mirror in store, they responded questionnaire previously conducted present analysis. Finally, data stemming from total 322 respondents were used Partial Least Squares (PLS) analysis was performed using...
It is not known whether the machine-smoked nicotine yield of usual brand cigarette smoked associated with chances success quit attempts. This study aimed to assess this association.
The aim of this study was to evaluate the effect additional motivational enhancement through telephone-based counseling on short- and long-term smoking abstinence among Korean adolescents.A comparative retrospective conducted based longitudinal follow up in Quitline from 2010 2017. A total 533 178 adolescent smokers voluntarily participated 1-year quitting only (group A, who were ready quit) 4-week interviewing before B, ambivalent about quitting), respectively. outcomes self-reported...
Background: The epidemiology of stroke and acute myocardial infarction (AMI) in Korea is limited by inaccurate methods for estimating incidence. Therefore, this study aimed to build the system national statistics AMI using claims-based identification algorithms. Methods: We identified algorithms based on 2018 National Health Insurance Service (NHIS) data. were validated investigation medical records sampled cases including patient groups control a 2-stage stratified sampling method. divided...