A5075619842- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer and Skin Lesions
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- Axon Guidance and Neuronal Signaling
- Amino Acid Enzymes and Metabolism
- FOXO transcription factor regulation
- Digestive system and related health
- Metastasis and carcinoma case studies
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
Jeju National University Hospital
2016-2025
Samsung Medical Center
2025
Sungkyunkwan University
2025
Vanderbilt University Medical Center
2023-2024
Jeju National University
2016-2024
National University College
2011-2024
Icahn School of Medicine at Mount Sinai
2024
Seoul National University Hospital
2009-2016
Seoul National University
2009-2016
Eulji University Hospital
2016
Elements of field cancerization, including atrophic gastritis, metaplasia, and dysplasia, promote gastric cancer development in association with chronic inflammation. However, it remains unclear how stroma changes during carcinogenesis the contributes to progression preneoplasia. Here we investigated heterogeneity fibroblasts, one most important elements stroma, their roles neoplastic transformation metaplasia.We used single-cell transcriptomics evaluate cellular mucosal cells from patients...
Gastric carcinogenesis develops within a sequential carcinogenic cascade from precancerous metaplasia to dysplasia and adenocarcinoma, oncogenic gene activation can drive the process. Metabolic reprogramming is considered key mechanism for cancer cell growth proliferation. However, how metabolic changes contribute progression of remains unclear. We have examined dynamics during gastric using novel mouse model that induces Kras in zymogen-secreting chief cells.
Lgr5 was identified as a promising gastrointestinal tract stem cell marker in mice. Lineage tracing indicates that Lgr5+ cells may not only be the responsible for origin of tumors; they also so-called cancer cells. In present study, we investigated presence and their biological significance normal human gastric mucosa tumors. RNAscope, newly developed RNA situ hybridization technique, specifically labeled at basal glands antrum. Notably, number remarkably increased intestinal metaplasia....
Intestinal-type gastric adenocarcinoma arises in a field of pre-existing metaplasia. While biomarkers cancer and metaplasia have been identified, the definition dysplastic transition as critical point evolution has remained obscure. We evaluated Trop2 putative marker from to dysplasia stomach multiple mouse models induction progression. In addition, TROP2 expression was human samples by immunostaining tissue microarrays for metaplasia, dysplasia, cancer. Dysplastic organoids were vitro...
Background & AimsMetaplasia in the stomach is highly associated with development of intestinal-type gastric cancer. Two types metaplasias, spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal (IM), are considered precancerous lesions. However, it remains unclear how SPEM IM related. Here we investigated a new lineage-specific marker for cells, aquaporin 5 (AQP5), to assist identification these 2 metaplasias.MethodsDrug- or Helicobacter felis (H felis) infection-induced mouse...
Backgrounds & AimsPrecancerous metaplasia progression to dysplasia can increase the risk of gastric cancers. However, effective strategies specifically target these precancerous lesions are currently lacking. To address this, we aimed identify key signaling pathways that upregulated during and critical for stem cell survival function in dysplasia.MethodsTo assess response chemotherapeutic drugs, used metaplastic dysplastic organoids derived from Mist1-Kras mice 20 human organoid lines...
The genetic risk for hypertensive disorders of pregnancy is linked with the development atherosclerotic cardiovascular disease. However, effects lifestyle and metabolic syndrome on disease have not been evaluated. Here, we assess long-term association between these factors in women pregnancy. We evaluate using a genome-wide polygenic score derived from large-scale GWAS. incidence evaluated according to risk, lifestyle, syndrome. Individuals very high 53.0% higher chance developing than those...
Gastric intestinal metaplasia (IM) is a highly prevalent preneoplastic lesion; however, the molecular mechanisms regulating its development remain unclear. We have previously shown that population of cells expressing stem cell (ISC) marker LGR5 increases remarkably in IM. In this study, we further investigated characteristics these LGR5+ IM by examining expression profile several ISC markers. Notably, found markers—including OLFM4 and EPHB2—are positively associated with CDX2 non-tumorous...
Purpose Lapatinib is a candidate drug for treatment of trastuzumab-resistant, human epidermal growth factor receptor 2 (HER2)–positive gastric cancer (GC). Unfortunately, lapatinib resistance renders this ineffective. The present study investigated the implication forkhead box O1 (FOXO1) signaling in acquired HER2-positive GC cells. Materials and Methods Lapatinib-resistant cell lines (SNU-216 LR2-8) were generated vitro by chronic exposure lapatinib-sensitive, SNU-216 cells to lapatinib. LR...
Cancer-associated fibroblasts (CAFs) play important roles in cancer progression through their complex interactions with cells. The secreted bone morphogenetic protein antagonist, gremlin1 (GREM1) is expressed by the CAFs of basal cell carcinomas (BCCs), and promotes growth In this study, we investigated expression GREM1 mRNAs various benign malignant skin tumors, including BCC subtypes. Analysis RNA situ hybridization (ISH) revealed that scar tissue α-smooth muscle actin (α-SMA), whereas...
Gastric cancer remains the leading cause of cancer-related deaths in Northeast Asia. Population-based endoscopic screenings region have yielded successful results early detection gastric tumors. Endoscopic screening rates are continuously increasing, and there is a need for an automatic computerized diagnostic system to reduce burden. In this study, we developed algorithm classify epithelial tumors automatically assessed its performance large series biopsies benefits as assistance tool.Using...
Intestinal stem cell (ISC) markers such as LGR5, ASCL2, EPHB2 and OLFM4, their clinical implications have been studied extensively in colorectal cancers (CRCs). However, little is known about expression precancerous lesions of CRCs. Here, we investigated the distribution ISC serrated polyps conventional adenomas.Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that all were up-regulated significantly adenomas with low-grade dysplasia (CALGs) compared other lesions....
AIMTo investigated the relationships between HER2, c-Jun N-terminal kinase (JNK) and protein B (AKT) with respect to metastatic potential of HER2-positive
Basal cell carcinoma (BCC) is the most common human cancer, characterized by aberrant activation of hedgehog (HH) signaling pathway resulting from mutations in patched 1 (PTCH1) or smoothened (SMO) genes. In present study, to uncover expression profile HH signaling-related molecules, we thoroughly examined mRNA and protein levels six molecules including GLI1, GLI2, PTCH1, PTCH2, SHH, SMO BCC various other cutaneous tumors. Real-time PCR analysis demonstrated that showed remarkably enhanced...
Abstract We aimed to investigate the expression profile of SPARC-related modular calcium-binding protein 2 (SMOC2) during colorectal cancer (CRC) progression and assess its prognostic impact in CRC patients. In our study, we showed that SMOC2 transcript level was higher samples than normal mucosa ( P = 0.017); this not associated with candidate stem cell markers CD44 , CD166 CD133 CD24 ) or intestinal LGR5 ASCL2 EPHB2 except for OLFM4 0.04). Immunohistochemical analysis SMOC2-positive cells...