A5005437154- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Ovarian cancer diagnosis and treatment
- Bone health and osteoporosis research
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Eosinophilic Esophagitis
- Renal cell carcinoma treatment
- Appendicitis Diagnosis and Management
- Spine and Intervertebral Disc Pathology
- Zoonotic diseases and public health
- IL-33, ST2, and ILC Pathways
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Hip and Femur Fractures
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
University of Chicago Medical Center
2022-2024
University of Chicago
2024
Rosalind Franklin University of Medicine and Science
2020
OBJECTIVE Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need revision than patients normal bone mineral densities (BMDs). To this end, the authors compared following single-level lumbar fusion in BMD those osteoporosis. The secondary outcome was to investigate effects pretreatment medications that prevent loss (e.g., teriparatide, bisphosphonates, denosumab) on these...
PURPOSE Conventional surveillance methods are poorly sensitive for monitoring appendiceal cancers (AC). This study investigated the utility of circulating tumor DNA (ctDNA) in evaluating systemic therapy response and recurrence after surgery AC. METHODS Patients from two specialized centers who underwent tumor-informed ctDNA testing (Signatera) were evaluated to determine association between detection. In addition, accuracy detection during diagnosis complete cytoreductive (CRS) grade 2-3...
The somatic mutation of fms-like tyrosine kinase 3 (
4178 Background: The incidence of early-onset (age <50) gastrointestinal cancers, including early onset Appendiceal Adenocarcinoma (EOAA) is on the rise, however reported data etiology, treatment, and outcomes scarce. Here we present for EOAA patients treated at a single high-volume center. Methods: Records (pts) with were reviewed. Clinicopathological genomic abstracted. Pts aged 18 - 49 years diagnosis (AA) seen UCMC between 2013 2023 included. primary outcome Overall survival (OS) was...
4179 Background: Data regarding predictive biomarkers in Appendiceal Adenocarcinoma (AA) is scarce. GNAS mutations, frequent mucinous AA, have been linked with poor objective response (OR) to chemotherapy. We hypothesize that activating mutations are associated differential outcomes for metastatic AA treated Methods: reviewed the records of patients (pts) seen between 2013 and 2023. Pts who received 5-Flurouracil/Capecitabine (5-FU/Cape) based chemotherapy at least 3 months (m)...
4170 Background: AC frequently present with peritoneal metastases (PM) which are difficult to accurately measure imaging techniques or serum tumor markers. ctDNA is a novel, promising biomarker assess minimal residual disease (MRD) and therapy response. Its utility in PM poorly studied due the rarity of this condition. This report on role management. Methods: Patients managed at two high volume centers between 01/01/2019 12/15/2022were included study. CtDNA measurements were prospectively...
e15609 Background: HG-NEC of the GI tract are rare and aggressive neoplasms with poor prognosis. Approximately 37.5% extra-pulmonary NEC origin most commonly located in esophagus, stomach, pancreas colon (1,2). Median survival 7.5 months, range 5.7 months to 25.1 has been reported (2). However, data regarding response immunotherapy, as well molecularly directed therapies sparse. In this study, we conducted a retrospective review objective assess role modern diagnostics clinical outcomes....