A5102802071- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Enhanced Recovery After Surgery
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Bariatric Surgery and Outcomes
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
New Generation University College
2007-2024
National University College
2005-2024
Samsung (South Korea)
2024
National Cancer Center
2014-2024
Xi'an Chest Hospital
2023
Changwon National University
2021
Gyeongsang National University
2021
Henan Cancer Hospital
2020
Two types of cells are cultured from the human peripheral blood, early endothelial progenitor (EPCs) and outgrowth (OECs), as previously reported. Here, we further characterize these cells, especially with respect to their different origins functions both in vitro vivo. We also investigated whether combination cell shows synergism during neovascularization.Early EPCs were heterogeneously made up CD14+ monocyte-derived which secrete cytokines, CD14(-)-derived contain high levels (CD34+)KDR+...
To determine the safety of laparoscopy-assisted distal gastrectomy (LADG) compared with open (ODG) in patients clinical stage I gastric cancer Korea.There is still a lack large-scale, multicenter randomized trials regarding LADG.A phase 3, multicenter, prospective controlled trial was conducted. The primary end point 5-year overall survival. Morbidity within 30 postoperative days and surgical mortality were to evaluate LADG as secondary point: A total 1416 randomly assigned group (n = 705)...
microRNAs (miRNAs) play integral roles in diverse processes including tumorigenesis. miRNA gene loci are often found close conjunction, and such clustered genes transcribed from a common promoter to generate polycistronic primary transcript. The transcript (pri-miRNA) is then processed by two RNase III proteins release the mature miRNAs. Although it has been speculated that miRNAs same cluster may related biological functions, this not experimentally addressed. Here we report clusters...
<h3>Importance</h3> Laparoscopic distal gastrectomy is gaining popularity over open for gastric cancer because of better early postoperative outcomes. However, to our knowledge, no studies have proved whether laparoscopic oncologically equivalent gastrectomy. <h3>Objective</h3> To examine the long-term survival among patients with stage I undergoing noninferior that <h3>Design</h3> The Korean Laparoendoscopic Gastrointestinal Surgery Study (KLASS) group, which includes 15 surgeons from 13...
The aim of the study was to evaluate short-term outcomes KLASS-02-RCT, a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy (LDG) with D2 lymphadenectomy open (ODG).Although several benefits gastric cancer surgery have been reported, strong evidence is still limited, especially in locally advanced which requires extensive lymph node dissection.Enrollment criteria included histologically confirmed cT2-4a and N0-1 adenocarcinoma. Thirty-day morbidity, 90-day...
PURPOSE It is unclear whether laparoscopic distal gastrectomy for locally advanced gastric cancer oncologically equivalent to open gastrectomy. The noninferiority of subtotal with D2 lymphadenectomy compared surgery in terms 3-year relapse-free survival rate was evaluated. PATIENTS AND METHODS A phase III, open-label, randomized controlled trial conducted patients histologically proven adenocarcinoma suitable primary end point the rate; upper limit hazard ratio (HR) 1.43 between and groups....
The aim of this study was to combine clinicopathologic variables associated with overall survival after gastric resection D2 lymphadenectomy (D2 gastrectomy) for cancer into a prediction nomogram.We retrospectively analyzed 7,954 patients who underwent gastrectomy at Seoul National University Hospital (SNUH) in Seoul, Korea. Two thirds the were randomly assigned training set (n = 5,300), and one third validation 2,654). Multivariate analysis by Cox proportional hazards regression performed...
Objective: To compare short-term surgical outcomes including financial cost of robotic and laparoscopic gastrectomy. Background: Despite a lack supporting evidence, surgery has been increasingly adopted as minimally invasive modality for the treatment gastric cancer because its assumed technical superiority over conventional laparoscopy. Methods: A prospective, multicenter comparative study was conducted. Patients were matched according to surgeon, extent resection, sex. The primary endpoint...
Objective: We investigated microsatellite instability (MSI) status and programed cell death ligand 1 (PD-L1) expression as predictors of prognosis responsiveness to chemotherapy for stage II/III gastric cancer. Background: The clinical implications MSI PD-L1 in cancer have not been well-elucidated. Methods: Tumor specimens information were collected from patients enrolled the CLASSIC trial—a randomized controlled study capecitabine plus oxaliplatin-based adjuvant chemotherapy. Five...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal originating in gastrointestinal tract. With introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these have become a model multidisciplinary oncological treatment. Although Western clinical guidelines available GISTs, such as those published by National Comprehensive Cancer Network (NCCN) and European Society Medical Oncology (ESMO), situations Asian countries different from terms...
Background The purpose of this study was to evaluate the nationwide benefit and cost national cancer screening program (NCSP) for gastric treatment. Methods For nationwide, population‐based study, Korean National Health Insurance Big Data Base, which included cancer–related treatment information costs all patients with who were 40 years old or older between 2004 2013, restructured. Patients participated in NCSP at least once (the group) compared those did not participate nonscreening group)....
Abstract Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment propagation, affecting accuracy of modeling cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 matched patient (PT) samples from 509 models. CNA inferences based on DNA sequencing microarray data displayed substantially higher resolution...
Aims: Epidermal growth factor receptor (EGFR) expression has been observed in a variety of solid tumours with the potential new targeted therapeutic agents. The aim was to evaluate EGFR status gastric carcinoma (GC) using immunohistochemistry (IHC) and fluorescence situ hybridization (FISH). Methods results: evaluated GC tissues from 511 patients IHC FISH. In addition, clinicopathological characteristics were examined results compared status. One hundred forty cases (27.4%) showed...
Germline CDH1 point or small frameshift mutations can be identified in 30–50% of hereditary diffuse gastric cancer (HDGC) families. We hypothesized that genomic rearrangements would found HDGC and 160 families with either two cancers first-degree relatives at least one (DGC) diagnosed before age 50, three more DGC close any age. Sixty-seven carried germline mutations. screened DNA from the 93 mutation negative probands for large by Multiplex Ligation-Dependent Probe Amplification. Potential...
Abstract BACKGROUND: The seventh TNM staging system for gastric cancer of the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) had a more detailed classification than sixth both tumor (T) and lymph nodes (N). authors compared survival rates assessed by with those system. METHODS: analyzed prospectively collected database patients who underwent surgery at Seoul National University Hospital between 1986 2006, calculated 9998 cases primary cancer, R0 resection,...
Abstract The loss of tumour suppressor genes (TSGs) is a key event in many human cancers, including gastric carcinoma. Many TSG candidates have been studied, but their roles carcinogenesis remain unclear. To clarify the clinical significance expression carcinoma, various (p53, E‐cadherin, FHIT, smad4, rb, VHL, PTEN, MGMT, p16, and KAI1), as well other proteins (bcl‐2, MUC1, MUC2, MUC5AC, MUC6, CEA, CD44, β‐catenin, C‐erbB2, cyclin B2), was evaluated immunohistochemically 329 consecutive...