A5100604639- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Gastrointestinal Tumor Research and Treatment
- Cholesterol and Lipid Metabolism
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Plant biochemistry and biosynthesis
- MicroRNA in disease regulation
- Ophthalmology and Visual Impairment Studies
- Steroid Chemistry and Biochemistry
- Intraocular Surgery and Lenses
- Neurological Disorders and Treatments
- Lipid metabolism and biosynthesis
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- RNA modifications and cancer
- RNA Research and Splicing
- Retinopathy of Prematurity Studies
- Optical Coherence Tomography Applications
- Piperaceae Chemical and Biological Studies
- Natural product bioactivities and synthesis
- Microbial Metabolism and Applications
- Retinal Development and Disorders
Seoul National University Hospital
2016-2025
Seoul National University
2016-2025
Trinity College Dublin
2024-2025
Kyung Hee University Medical Center
2024
Seoul National University Children's Hospital
2020-2024
Chonnam National University
2016-2024
Chonnam National University Hwasun Hospital
2024
New Generation University College
2013-2023
National Research Foundation of Korea
2023
Kyung Hee University
2022
RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic Dicer generate mature miRNAs. While (class III) and other simple I) have been studied intensively, class II enzyme remains be characterized. Here we dissected action mechanism of human generating mutants characterizing its new interacting partner, DGCR8. basic was found similar Dicer; domains...
microRNAs (miRNAs) play integral roles in diverse processes including tumorigenesis. miRNA gene loci are often found close conjunction, and such clustered genes transcribed from a common promoter to generate polycistronic primary transcript. The transcript (pri-miRNA) is then processed by two RNase III proteins release the mature miRNAs. Although it has been speculated that miRNAs same cluster may related biological functions, this not experimentally addressed. Here we report clusters...
Significance MicroRNAs (miRNAs) are noncoding RNAs with diverse roles in development and pathogenesis. Biogenesis of canonical miRNA requires nuclear processing by DROSHA, export Exportin 5, cytoplasmic DICER. To gain a deeper understanding the maturation processes, we here ablated DROSHA , 5 DICER genes using same human cell line. Canonical production was abolished -deleted cells, revealing an irreplaceable role DROSHA. Interestingly, however, some miRNAs were still produced without albeit...
Substituents can induce dramatic changes in the photoluminescence properties of N,O-chelated boron complexes. Specifically, complexes 2-(benzothiazol-2-yl)phenols become bright deep blue- and orange-red-emitting materials depending on amino substituents at 5- 4-positions 2-(benzothiazol-2-yl)phenol, respectively. Absorption emission data show that resulting have little or small overlap between absorption spectra and, furthermore, X-ray crystal structures for both blue orange-red indicate...
Gain-of-function mutations and KIT overexpression are well-known tumorigenesis mechanisms in gastrointestinal stromal tumors (GIST). This study aimed to discover microRNAs (miRNA) that target reveal the relationship between discovered miRNAs expression GISTs.Fresh-frozen GISTs from 31 patients were used confirm miR-494 using quantitative reverse transcription-PCR assess levels Western blotting protein levels. A luciferase assay was conducted for evaluation. The functional effects of on...
Précis: A spectral-domain optical coherence tomography (SD-OCT) based deep learning system detected glaucomatous structural change with high sensitivity and specificity. It outperformed the clinical diagnostic parameters in discriminating eyes from healthy eyes. Purpose: The purpose of this study was to assess performance a classifier for detection on SD-OCT. Methods: Three hundred fifty image sets ganglion cell-inner plexiform layer (GCIPL) retinal nerve fiber (RNFL) SD-OCT 86 307 196...