A5060804217- Immune Cell Function and Interaction
- Thin-Film Transistor Technologies
- Organic Light-Emitting Diodes Research
- T-cell and B-cell Immunology
- Mast cells and histamine
- Semiconductor materials and devices
- Cytomegalovirus and herpesvirus research
- PI3K/AKT/mTOR signaling in cancer
- Organic Electronics and Photovoltaics
- Polyamine Metabolism and Applications
- Photonic Crystals and Applications
- Enterobacteriaceae and Cronobacter Research
- Analytical Chemistry and Sensors
- Antibiotic Resistance in Bacteria
- Image and Video Quality Assessment
- Graphene research and applications
- Silicon Nanostructures and Photoluminescence
- Semiconductor Lasers and Optical Devices
- Liquid Crystal Research Advancements
- Advanced Memory and Neural Computing
- Immune Response and Inflammation
- Nanomaterials and Printing Technologies
- Quantum Dots Synthesis And Properties
- Green IT and Sustainability
- MicroRNA in disease regulation
Electronics and Telecommunications Research Institute
2012-2023
Inha University
2015-2022
Seoul National University
1996-2021
Duke University Hospital
2010-2016
Duke Medical Center
2010-2016
Korea University
1994-2016
Duke University
2011-2014
Kwangwoon University
2008-2010
Hanyang University
2010
Massachusetts Institute of Technology
2004
Significance The mechanistic or mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. promyelocytic leukemia zinc-finger transcription factor (PLZF) known be critical not only for invariant natural killer T ( i NKT)-cell development effector program differentiation lymphocytes, but also many other developmental programs. Our study...
Terminal maturation of invariant NKT (iNKT) cells from stage 2 (CD44+NK1.1–) to 3 (CD44+NK1.1+) is accompanied by a functional acquisition predominant IFN-γ–producing (iNKT-1) phenotype; however, some develop into IL-17–producing iNKT (iNKT-17) cells. iNKT-17 are rare and restricted CD44+NK1.1– lineage. It unclear how terminal regulated what factors mediate the predominance iNKT-1 compared with iNKT-17. The tumor suppressor tuberous sclerosis 1 (TSC1) an important negative regulator mTOR...
Colistin is a last-resort antimicrobial against multidrug-resistant gram-negative bacteria. The occurrence and spread of colistin resistance in humans animals have been reported globally. This study was performed to investigate the prevalence susceptibility mcr-harboring colistin-resistant Enterobacteriaceae from retail vegetables food South Korea 2018. mcr-1 gene detected Escherichia coli isolates 0.076% (1/1324) vegetables, 5.9% (2/34) chickens, 6.8% (4/59) pigs, 0% (0/57) cattle. Other...
We present herein the first report of organic/inorganic hybrid thin-film encapsulation (TFE) developed as an process for mass production in display industry. The proposed method was applied to fabricate a top-emitting organic light-emitting device (TEOLED). TFE has 1.5 dyad structure and fabricated using plasma-enhanced atomic layer deposition (PEALD) inkjet printing (IJP) processes that can be operations Currently, industries use inorganic thin films such SiNx SiOxNy through chemical vapor...
Organic light-emitting diode (OLED) microdisplays have received great attention owing to their excellent performance for augmented reality/virtual reality devices applications. However, high pixel density of OLED microdisplay causes electrical crosstalk, resulting in color distortion. This study investigated the current crosstalk ratio and changes gamut caused by between sub-pixels high-resolution full-color microdisplays. A structure 3147 pixels per inch (PPI) with four a single-stack white...
We present differential scanning calorimetry, optical and X-ray diffraction measurements for a new dimesogenic liquid crystal compound (KIS).The rich polymorphism of this includes smectic phases rare phase transitions.In
Dendritic cell (DC) maturation is characterized by upregulation of cell-surface MHC class II (MHC-II) and costimulatory molecules, production a variety cytokines that can shape both innate adaptive immunity. Paradoxically, transcription the MHC-II genes, as well its activator, CIITA, rapidly silenced during DC maturation. The mechanisms control CIITA/MHC-II expression silencing have not been fully understood. We report in this article tumor suppressor tuberous sclerosis complex 1 (TSC1)...
The engagement of the T cell receptor (TCR) induces generation diacylglycerol (DAG), an important second messenger activating both Ras/Erk and PKCθ/NFκB pathways. DAG kinases (DGKs) participate in metabolism by converting it to phosphatidic acid. DGKζ has been demonstrated be able inhibit signaling following TCR engagement. Deficiency increases sensitivity cells stimulation, resulting enhanced activation ex vivo vivo. However, mechanisms that control expression are poorly understood. Here we...
Abstract Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ remain poorly understood. We found myeloid-specific deletion Raptor, an essential component mammalian/mechanistic target rapamycin complex (mTORC)1, resulted in a marked decrease this population cells accompanying altered phenotypic features and impaired phagocytosis activity. demonstrated further Raptor/mTORC1 deficiency did not affect development, but...
Abstract The increasing prevalence of oxyimino-cephalosporin-resistant Enterobacteriaceae has become a global concern because their clinical impact on both human and veterinary medicine. present study determined the prevalence, antimicrobial susceptibility, molecular genetic features extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) isolates from raw vegetables. A total 1324 samples were collected two agricultural wholesale markets in Incheon, South Korea 2018....
Extended-spectrum β-lactam antimicrobials have been broadly used in food animals and humans to control infectious diseases. However, the emergence rapid spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, mainly Escherichia coli, seriously threatened global health recent decades. In this study, we determined prevalence, antimicrobial susceptibility, genetic properties ESBL-producing E. coli (ESBL-EC) strains isolated from South Korea. A total 150 fecal samples...
A reduction and infiltration process for a naturally occurring 3D bicontinuous structure is demonstrated. sea urchin exoskeleton can be engineered in top–down fashion to create low absorption, high dielectric contrast photonic crystals with stop band the mid-IR regime. The Figure shows sample cut half where one (right) has been pyrolyzed, demonstrating excellent structural fidelity of replication-reduction process.
Analysis of the molecular etiologies SCID has led to important insights into control immune cell development. Most cases result from either X-linked or autosomal recessive inheritance mutations in a known causative gene. However, some cases, etiology remains unclear. To identify cause patient lack protein-tyrosine phosphatase CD45, we used SNP arrays and whole-exome sequencing. The patient's mother was heterozygous for an inactivating mutation CD45 but paternal alleles exhibited no...
Type I NKT cells, or invariant (iNKT) express a semi-invariant TCR characterized by its unique Vα14-Jα18 usage (iVα14TCR). Upon interaction with glycolipid/CD1d complexes, the iVα14TCRs transduce signals that are essential for iNKT selection and maturation. However, it remains unclear how these regulated important such regulations during development. Diacylglycerol (DAG) is an second messenger downstream of activates protein kinase C-IκB (IKK)α/β-NF-κB pathway, known to be crucial...
Abstract The manipulation of signals downstream the TCR can have profound consequences for T cell development, function, and homeostasis. Diacylglycerol (DAG) produced after stimulation functions as a secondary messenger mediates signaling to Ras-MEK-Erk NF-κB pathways in cells. DAG kinases (DGKs) convert into phosphatidic acid, resulting termination signaling. In this study, we demonstrate that metabolism by DGKs serve crucial function viral clearance upon lymphocytic choriomeningitis virus...
Microdisplay is a key technology for realizing augmented reality (AR) and mixed (MR) devices, which have attracted much attention of late. Even though the operating voltage in tandem structure higher than that single structure, 2-stack OLED exhibited 20,000 cd/m2 at 9 V, compatible with CMOS circuit driving. Due to its top-emitting geometry device well-controlled thickness white spectrum (0.26, 0.26) color coordinates. The pixel density fabricated microdisplay panel was about 2350 pixels per...
Abstract Human CMV encodes four unique short region proteins (US), US2, US3, US6, and US11, each independently sufficient for causing the down-regulation of MHC class I molecules on cell surface. This allows infected cells to evade recognition by cytotoxic T but leaves them susceptible NK cells, which lyse that lack molecules. Another human CMV-encoded protein, long protein 18 (UL18), is an homolog might provide a mechanism inhibiting response. The sequence similarities between UL18 along...
Abstract Activation of the transcription factor NF-κB is critical for cytokine production and T cell survival after TCR engagement. The effects persistent activity on function are poorly understood. In this study, using a murine model that expresses constitutively active form inhibitor kinase β (caIKKβ) in cell-specific manner, we demonstrate chronic signaling promotes apoptosis, attenuates responsiveness to TCR-mediated stimulation vitro, impairs responses bacterial infection vivo. caIKKβ...