A5100677361- Advanced Memory and Neural Computing
- Ferroelectric and Negative Capacitance Devices
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neural Engineering
- Pulmonary Hypertension Research and Treatments
- Lymphatic System and Diseases
- Planarian Biology and Electrostimulation
- Semiconductor materials and devices
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Circadian rhythm and melatonin
- Renin-Angiotensin System Studies
- Transition Metal Oxide Nanomaterials
- Heart Rate Variability and Autonomic Control
- Eicosanoids and Hypertension Pharmacology
- Dietary Effects on Health
- Photoreceptor and optogenetics research
- Plant Molecular Biology Research
- Retinal Diseases and Treatments
- Conducting polymers and applications
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Cardiomyopathy and Myosin Studies
- Photosynthetic Processes and Mechanisms
- Diabetes Treatment and Management
Myongji University
2024-2025
University of Missouri
2020-2024
Yeungnam University
2023
Seoul National University
2014-2023
Tulane University
2023
Dundalk Institute of Technology
2023
University of Missouri Hospital
2023
Hanyang University
2002-2023
University of North Texas
2022
University of Suwon
2022
We have characterized the function of a plant R2R3‐MYB transcription factor, Arabidopsis thaliana MYB20 (AtMYB20). Transgenic plants overexpressing AtMYB20 ( ‐ OX ) enhanced salt stress tolerance while repression lines SRDX were more vulnerable to NaCl than wild‐type plants. Following treatment, expressions ABI1 , ABI2 and AtPP2CA which encode type 2C serine/threonine protein phosphatases (PP2Cs) that act as negative regulators in abscisic acid (ABA) signaling, suppressed but induced . The...
The biomimetic characteristics of the memristor as an electronic synapse and neuron have inspired advent new information technology in neuromorphic computing. application memristors can be extended to artificial nerves on condition presence receptors which transfer external stimuli internal nerve system. In this work, nociceptor behaviors are demonstrated from Pt/HfO2 /TiN for receptors. device shows four specific nociceptive behaviors; threshold, relaxation, allodynia, hyperalgesia,...
Cerebrospinal fluid (CSF) in the subarachnoid space around brain has long been known to drain through lymphatics cervical lymph nodes
Abstract The phospholipase A2 (PLA2) superfamily of lipolytic enzymes is involved in a number essential biological processes, such as inflammation, development, host defense, and signal transduction. Despite the proven involvement plant PLA2s many functions, including senescence, wounding, elicitor stress responses, pathogen relatively little known about PLA2s, their genes essentially remain uncharacterized. We characterized three four Arabidopsis thaliana PLA2 paralogs (PLA2-β, -γ, -Δ)...
Abstract Various possibilities have been proposed as the cause of doped‐ or undoped‐HfO 2 thin film materials showing unusual ferroelectricity. These assumptions are based on empirical results, yet finding origin unprecedented ferroelectricity within HfO has suffered from a serious gap between its theoretical calculation, mostly thermodynamic approach and actual experimental results. To fill gap, this study proposes to consider kinetic energy, providing evidence energy barrier upon phase...
Abstract Conductive bridge random access memory (CBRAM) has been regarded as a promising candidate for the next‐generation nonvolatile technology. Even with great performance of CBRAM, global generation and overinjection cations after much repetitive switching cannot be prevented. The into an electrolyte layer causes high‐resistance‐state resistance ( R HRS ) degradation, on/off ratio reduction, eventual failure. It also degrades uniformity. In this work, Cu‐cone‐structure‐embedded TiN/TiO 2...
To elucidate the cellular functions of phospholipase A2 in plants, an Arabidopsis cDNA encoding a secretory low molecular weight (AtsPLA2β) was isolated. Phenotype analyses transgenic plants showed that overexpression AtsPLA2β promotes cell elongation, resulting prolonged leaf petioles and inflorescence stems, whereas RNA interference–mediated silencing expression retards shortened stems. is expressed cortical, vascular, endodermal cells actively growing tissues stems hypocotyls. then...
Insulin-like growth factor-1 (IGF1) regulates differentiation and of tissues reduces stress injury. IGF1 also in a tissue-specific manner modulates the lipid storage capacity adipocytes vitro, but its roles adipose tissue development response to are not known.To study vivo, cellular sources Igf1 expression were identified mice generated with targeted deletion macrophages. The effects adipocyte macrophage deficiency on chronic (high-fat feeding) acute (cold challenge) studied.The by was...
Resistance switching (RS) devices with ultra-thin Ta2O5 layer (0.5-2.0 nm) a cell diameter of 28 nm were fabricated. The performance the was tested by voltage-driven current-voltage (I-V) sweep and closed-loop pulse (CLPS) tests. A Ta placed beneath to act as an oxygen vacancy reservoir. device smallest thickness (0.5 showed normal properties gradual change in resistance I-V or CLPS high reliability. By contrast, other higher (1.0-2.0 abrupt several abnormal behaviours, degraded...
The thin-film growth conditions in a plasma-enhanced atomic layer deposition for the (3.0–4.5) nm thick HfO2 film were optimized to use as resistive switching element neuromorphic circuit. was intended be used feasible synapse with analog-type conductance-tuning capability. 4.5 films on both conventional TiN and new RuO2 bottom electrode required electroforming process them operate memory, which primary source of undesirable characteristics synapse. Therefore, electroforming-free performance...
Stateful logic enables highly energy‐efficient computation because the time and energy consumption for data transfer between memory processing units in traditional system can significantly be saved due to combined functionalities of operation nonvolatile memory. The primitive circuit, usually composed resistive switching or memristor units, is fundamental kernel element build a stateful family. However, current circuits cannot configured devices from adjacent layers 3D crossbar array (CBA)...
Key points Spontaneous contractions are essential for normal lymph transport and these exquisitely sensitive to the K ATP channel activator pinacidil. Kir6.1 SUR2B subunits expressed in mouse lymphatic smooth muscle (LSM) form functional channels as verified by electrophysiological techniques. Global deletion of or SUR2 results severely impaired contractile responses Smooth muscle‐specific expression gain‐of‐function mutant (GoF) profound dysfunction LSM hyperpolarization that is partially...
Reactive oxygen species (ROS) and calcium ions (Ca2+) are among the major effectors of Ang II (angiotensin II) in vascular smooth muscle cells. ROS related to Ca2+ signaling or contraction induced by II, but little is known about their detailed functions. Here, NOX (NADPH oxidase), a source responsive was investigated regarding its contribution signaling.Vascular cells were primary cultured from rat aorta. monitored mainly using fura-2 HyPer family probes' respectively. Signals activating...
Recent breeding efforts in Brassica have focused on the development of new oilseed feedstock crop for biofuels (e.g., ethanol, biodiesel, bio-jet fuel), bio-industrial uses bio-plastics, lubricants), specialty fatty acids erucic acid), and producing low glucosinolates levels feed meal production animal consumption. We identified a novel opportunity to enhance availability nutritious, fresh leafy greens human Here, we demonstrated efficacy disarming 'mustard bomb' reaction reducing pungency...
The widely-used, tamoxifen-inducible, smooth muscle (SM)-specific Cre,
A double‐layer‐stacked 1 diode‐1 resistor (1D1R) cross‐bar array (CBA) resistance switching random access memory is fabricated. The TiO 2 ‐based Schottky diode and the unipolar comprise cell selector nonvolatile components, respectively. All fabrication processes are performed near room temperature through physical vapor deposition processes, performance degradation by thermal budget well suppressed. As a result, rectification ratio as high 1.4 × 10 9 achieved from appropriately cycled...
Colloidal quantum-dot light-emitting diodes (QD-LEDs) have been significantly improved in terms of device performance and lifetime by employing zinc oxide (ZnO) as an electron transport layer (ETL). Although atomic deposition (ALD) allows fabrication uniform, high-quality ZnO films with minimal defects, the high conductivity has hindered its straightforward application ETL QD-LEDs. Herein, we propose Al-doped ZnMgO (Al:ZnMgO) ETLs for QD-LEDs through a supercycle ALD, alternating depositions...
Neuronal nitric oxide synthase (NOS1 or nNOS) exerts negative inotropic and positive lusitropic effects through Ca(2+) handling processes in cardiac myocytes from healthy hearts. However, underlying mechanisms of NOS1 diseased hearts remain unclear. The present study aims to investigate this question angiotensin II (Ang II)-induced hypertensive rat (HP). Our results showed that the systolic function left ventricle (LV) was reduced diastolic unaltered (echocardiographic assessment) HP...
Introduction: Rodent models of cardiovascular disease have uncovered various types lymphatic vessel dysfunction that occur in association with atherosclerosis, type II diabetes and obesity. Previously, we presented vivo evidence for impaired drainage apolipoprotein E null ( ApoE −/− ) mice fed a high fat diet (HFD). Whether this impairment relates to the collecting lymphatics remains an open question. The mouse is well-established model disease, which rich cholesterol on deficient background...
Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of KATP channels. overactivity results a chronic reduction arterial tone hypotension, leading to other systemic cardiovascular complications. However, underlying mechanism lymphedema, developed >50% CS patients, unknown. We investigated whether lymphatic contractile dysfunction occurs mice expressing (Kir6.1[V65M]) or (SUR2[A478V], SUR2[R1154Q]). Pressure myograph...
Abstract Background High-mobility group box-1 (HMGB1) released from the tumor microenvironment plays a pivotal role in progression. HMGB1 serves as damaged-associated molecular pattern (DAMP) that induces angiogenesis and its development. Glycyrrhizin (GL) is an effective intracellular antagonist of HMGB1, but pharmacokinetics (PK) delivery to site deficient. To address this shortcoming, we developed lactoferrin-glycyrrhizin (Lf-GL) conjugate. Methods Biomolecular interaction between Lf-GL...