A5088375240- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Infant Nutrition and Health
- Gold and Silver Nanoparticles Synthesis and Applications
- Pancreatic function and diabetes
- Geochemistry and Geologic Mapping
- Photodynamic Therapy Research Studies
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Mineralogy and Gemology Studies
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Adenosine and Purinergic Signaling
- bioluminescence and chemiluminescence research
- Angiogenesis and VEGF in Cancer
- Metallurgical Processes and Thermodynamics
- Microencapsulation and Drying Processes
- Gout, Hyperuricemia, Uric Acid
- Electrochemical sensors and biosensors
- Advanced MRI Techniques and Applications
- Advancements in Transdermal Drug Delivery
Hanyang University
2016-2024
Jusung Engineering (South Korea)
2011
Inha University
2000
Edith Cowan University
1993
Abstract Owing to the strong absorption of water in near-infrared (NIR) region near 1.0 μm, this wavelength is considered unsuitable as an imaging and analytical signal biological environments. However, μm NIR can be converted into heat used a local water-molecular heating strategy for photothermal therapy tissues. Herein, we describe Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) emissive NPs target band water. Furthermore, introducing Tm ions water-heating improve...
Abstract Background The outcome of phototherapy, including photothermal therapy (PTT) and photodynamic (PDT) for glioblastoma multiforme (GBM), is disappointing due to insufficient photoconversion efficiency low targeting rate. development phototherapeutic agents that target GBM generate high heat potent ROS important overcome the weak anti-tumor effect. Results In this study, nanoconjugates composed gold nanoparticles (AuNPs) photosensitizers (PSs) were prepared by disulfide conjugation...
Orally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM) for patients with its highest incidence rate. Here, we develop a milk protein lactoferrin-conjugated AuNP oral absorption and targeting the GBM through interaction between lactoferrin (Lf) receptor (LfR) that highly expressed in intestine, blood-brain barrier GBM. For stability long circulation of AuNP, glutathione polyethylene glycol (PEG) introduced, which...
A therapeutic strategy that could address colitis of multiple etiologies while restoring the dysbiosis gut microbiota is attractive. Here, Aurozyme, a novel nanomedicine comprised gold nanoparticles (AuNPs) and glycyrrhizin (GL) with glycol chitosan coating layer, as promising approach for colitis, demonstrated. The unique feature Aurozyme conversion harmful peroxidase-like activity AuNPs to beneficial catalase-like due amine-rich environment provided by chitosan. This process enables...
Abstract Background High-mobility group box-1 (HMGB1) released from the tumor microenvironment plays a pivotal role in progression. HMGB1 serves as damaged-associated molecular pattern (DAMP) that induces angiogenesis and its development. Glycyrrhizin (GL) is an effective intracellular antagonist of HMGB1, but pharmacokinetics (PK) delivery to site deficient. To address this shortcoming, we developed lactoferrin-glycyrrhizin (Lf-GL) conjugate. Methods Biomolecular interaction between Lf-GL...
Abstract To resolve the problem of target specificity and light transmission to deep-seated tissues in photodynamic therapy (PDT), we report a cancer cell-targeted photosensitizer using photoprotein-conjugated upconversion nanoparticles (UCNPs) with high efficient deep tissues. Core-shell UCNPs low internal energy back transfer were conjugated recombinant proteins that consists (KillerRed; KR) lead peptide (LP). Under near infrared (NIR)-irradiating condition, UCNP-KR-LP generated superoxide...
Aurozymes Aurozyme, a novel nanozyme, effectively treats inflammatory bowel disease (IBD). Composed of gold nanoparticles and glycyrrhizin with glycol chitosan coating, it scavenges harmful radicals molecular patterns in colitis. Aurozyme's unique catalase-like activity converts hydroxyl to water oxygen, reducing inflammation promoting tissue repair. It also regulates gut microbiota, demonstrating its transformative potential for managing chronic conditions. More details can be found article...
In this study, we address the persistent challenge of providing adequate oxygen to transplanted cells by introducing a respiratoid biosystem. Central our strategy is chloroplast-transit-peptide (CTP), crucial for optimal oxygenation. Through conjugation CTP with alginate, achieve stabilization chloroplast structure. Strategically anchored outer membrane, not only ensures structural integrity but also upregulates key photosynthesis-associated genes. This biosystem demonstrates exceptional...
Abstract Background Glioblastoma is a highly malignant brain tumor associated with poor prognosis. Conventional therapeutic approaches have limitations due to their toxic effects on normal tissue and the development of cell resistance. This study aimed explore alternative mechanisms for glioblastoma treatment by targeting angiogenesis. Methods The investigated anti-angiogenic properties heparin in treatment. To overcome heparin, heparin-taurocholate conjugate (LHT7) was synthesized...