A5041753385- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Venous Thromboembolism Diagnosis and Management
- Phosphodiesterase function and regulation
Seoul National University
2016-2025
Seoul National University Bundang Hospital
2012-2025
Uijeongbu St. Mary's Hospital
2024
Catholic University of Korea
2024
Seoul National University Hospital
2013-2023
Chungbuk National University
2023
Weatherford College
2022
New Generation University College
2015-2021
Keio University
2019
Boramae Medical Center
2017
Background: The echocardiographic assessment of left ventricular (LV) diastolic dysfunction (LVDD) in patients with hypertrophic cardiomyopathy is complex and not well-established. We investigated whether the atrial reservoir strain (LARS) could be used to categorize LVDD this grading predictive heart failure (HF) events cardiomyopathy. Methods: A total 414 (aged 58.3±12.8 years; 65.7% male) were categorized using LARS-defined (LARS-DD) grades: ≥35% (grade 0), ≥24% <35%, ≥19% <24%,...
BACKGROUND: The morbidity and mortality rates of patients with heart failure (HF) functional mitral regurgitation (MR) remain substantial despite guideline-directed medical therapy for HF. We evaluated the efficacy ertugliflozin reduction MR associated HF mild to moderately reduced ejection fraction. METHODS: EFFORT trial (Ertugliflozin Functional Mitral Regurgitation) was a multicenter, double-blind, randomized examine hypothesis that sodium-glucose cotransporter 2 inhibitor is effective...
The interactions between macronutrients, the human gut microbiome, and their metabolites (short-chain fatty acids) were comprehensively investigated via an in vitro digestion fermentation model subjected to eight pulse species. 16S rRNA sequencing taxonomic analysis of digesta fermented for up 24 h revealed increase relative abundance health-detrimental genera represented by Escherichia-Shigella kidney bean, soybean, cowpea, chickpea, black bean samples. In contrast, health-positive genera,...
The 2016 American Society of Echocardiography/European Association Cardiovascular Imaging guidelines report that approximately 20% diastolic dysfunction is indeterminate and has limited diagnostic accuracy. Left atrial strain may help accurately categorize dysfunction; however, its exact roles remain unclear. This study investigated the impact left reservoir (LARS) association with exercise capacity in patients function. Among 687 who underwent cardiopulmonary tests supine bicycle stress...
Abstract Aims Left atrial (LA) dysfunction can be associated with left ventricular (LV) disorders; however, its clinical significance has not been well-studied in patients acute heart failure (AHF). We evaluated prognostic power of peak longitudinal strain (PALS) the atrium according to (HF) phenotypes and fibrillation (AF). Methods results From an AHF registry 4312 patients, we analysed PALS 3818 patients. Patients were categorized into tertiles. also divided HF [HF reduced ejection...
Abstract Differential diagnosis of left ventricular hypertrophy (LVH) is often obscure on echocardiography and requires numerous additional tests. We aimed to develop a deep learning algorithm aid in the differentiation common etiologies LVH (i.e. hypertensive heart disease [HHD], hypertrophic cardiomyopathy [HCM], light-chain cardiac amyloidosis [ALCA]) echocardiographic images. Echocardiograms 5 standard views (parasternal long-axis, parasternal short-axis, apical 4-chamber, 2-chamber,...
Temporal trends of the prevalence and incidence hypertrophic cardiomyopathy (HCM) have not been well established in Asian populations. Using Korean National Health Insurance Services database, we identified patients with a confirmed diagnosis HCM between 2010 2016. The annual HCM, their clinical characteristics were investigated. has increased from 0.016% (n = 6313) to 0.031% 13,035) During 7-year period, 13,229 newly diagnosed HCM. rate 4.15 (per 100,000 person-years) 5.6 age peaked during...
Abstract Background The effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiac function are not fully understood. We investigated the changes in diabetic patients according to presence and types heart failure (HF). Methods retrospectively identified 202 who underwent echocardiography before, 6 24 months after initiation SGLT2i. After propensity score matching with without SGLT2i, study population (n = 304) were categorized into group 1 (without HF nor SGLT2i; n 76), received...
Background: There is a lack of studies investigating the heterogeneity patients with aortic stenosis (AS). We explored whether cluster analysis identifies distinct subgroups different prognostic significances in AS. Methods: Newly diagnosed moderate or severe AS were prospectively enrolled between 2013 and 2016 (n=398, mean 71 years, 55% male). Among demographics, laboratory, echocardiography parameters (n=32), 11 variables selected through dimension reduction used for unsupervised...
Recommendations on physical activity (PA) for adults with hypertrophic cardiomyopathy (HCM) are not well established. We investigated the association of PA intensity mortality in general adult HCM population.A nationwide population-based cohort individuals who underwent health check-ups including questionnaires levels were identified from years 2009 to 2016 National Health Insurance Service database. Subjects reported no at baseline excluded. To estimate each individual's level, score (PAS)...
Aims Dyslipidaemia is a modifiable cardiovascular risk factor with prognostic implications. Current strategies for lipid management in young adults are largely based on expert recommendations. We investigated the risks of death and disease relation to each component establish evidence primary prevention adults. Methods In this nationwide population-based cohort study, we analysed 5,688,055 statin-naïve subjects, aged 20–39 years, undergoing general health check-ups between 2009 2014. The...
Background Many patients with heart failure (HF) experience changes in left ventricular ejection fraction (LVEF) during follow-up. We sought to evaluate the predictors and outcomes of different HF phenotypes according longitudinal EF. Methods Results A total 2104 acute underwent echocardiography at baseline Global strain was measured index admission. were defined as persistent reduced EF (persistent HFrEF, LVEF ≤40% follow-up), improved (LVEF≤40% >40% declined (LVEF>40% follow up), preserved...
Abstract Aims Despite well‐established benefits of sacubitril/valsartan for cardiac reverse remodelling and the prognosis patients with heart failure reduced ejection fraction (HFrEF), there are some limited therapeutic response, even optimal therapy. We assessed treatment response to in HFrEF, focusing on association between prognosis. Methods results Using a retrospective cohort consecutive HFrEF treated sacubitril/valsartan, we compared time trajectory function 415 (1258 echocardiograms),...
We investigated whether the evaluation of bone mineral density (BMD) provides independent and incremental prognostic value for predicting atherosclerotic cardiovascular disease (ASCVD) in women. A total 12 681 women aged 50-80 years (mean, 63.0±7.8 years) who underwent dual-energy X-ray absorptiometry were retrospectively analysed. assessed hazard ratio (HR) ASCVD events (ASCVD death, non-fatal myocardial infarction ischaemic stroke) according to BMD or a clinical diagnosis osteopenia...
Evaluating left ventricular diastolic function (LVDF) is crucial in echocardiography; however, the complexity and time demands of current guidelines challenge clinical use. This study aimed to develop an artificial intelligence (AI)-based framework for automatic LVDF assessment reduce subjectivity improve accuracy outcome prediction.
We sought to investigate the association of obesity and metabolic health status with incidence clinical hypertrophic cardiomyopathy (HCM) diagnosis in general population. Our goal was identify modifiable risk factors attenuate expression HCM, enabling management evolution from a mostly passive strategy stratification proactive modifying disease expression.Using nationwide population-based data Korean National Health Insurance Service, 28,679,891 people who were free prevalent HCM underwent...
In young adults, the role of mildly abnormal lipid levels and variability in risk atherosclerotic cardiovascular diseases remains uncertain.To investigate association these abnormalities profiles with myocardial infarction (MI) stroke population.From Korean National Health Insurance Service, a nationwide population-based cohort 1 934 324 statin-naive adults aged 20 to 39 years, ≥3 profile measurements without history MI stroke, were followed-up until date or December 31, 2017. The primary...
Objective To investigate whether low-normal left ventricular ejection fraction (LVEF) is associated with adverse outcomes in hypertrophic cardiomyopathy (HCM) and evaluate the incremental value of predictive power LVEF conventional HCM sudden cardiac death (SCD)-risk model. Methods This retrospective study included 1858 patients from two tertiary hospitals between 2008 2019. We classified into three categories: preserved ( ≥ 60%), low normal (50%–60%) reduced (<50%); there were 1399, 415,...