A5100719353- Renal Diseases and Glomerulopathies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Cardiac Imaging and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Complement system in diseases
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Diverse Approaches in Healthcare and Education Studies
- Renal and Vascular Pathologies
- Systemic Lupus Erythematosus Research
- Mesenchymal stem cell research
- Polyomavirus and related diseases
- Cardiovascular Effects of Exercise
- Tissue Engineering and Regenerative Medicine
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Neurological Complications and Syndromes
Seoul National University
1991-2025
Kyungpook National University Hospital
2019-2025
Kyungpook National University
2017-2025
Seoul National University Hospital
2012-2023
St. Paul's Hospital
2021
University of British Columbia
2021
Cornell University
2018-2020
Weill Cornell Medicine
2020
Amorepacific (South Korea)
2018-2019
Yeungnam University College
2000-2018
Background— We sought to identify preoperative predictors of clinical outcomes after surgery in patients with severe tricuspid regurgitation. Methods and Results— prospectively enrolled 61 consecutive (54 women, aged 57±9 years) isolated regurgitation undergoing corrective surgery. Twenty-one (34%) were New York Heart Association functional class II, 35 (57%) III, 5 (9%) IV. Fifty-seven (93%) had previous history left-sided valve Preoperative echocardiography revealed pulmonary artery...
The efficacy of intracoronary infusion granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk restenosis associated G-CSF-based cell therapy evaluated in setting drug eluting stent (DES) implantation.We randomly allocated 96 who underwent coronary revascularization DES for culprit lesion into 4 groups. Eighty-two completed...
To assess whether native T1 mapping provides noninvasive estimation of diffuse myocardial fibrosis and it correlates with subclinical dysfunction in asymptomatic patients aortic stenosis (AS).The local institutional review board approved the study, all gave informed consent. Eighty moderate or severe AS normal left ventricular (LV) ejection fraction (mean age, 67 years; range, 31-81 years) 15 sex-matched control subjects 33 23-41 were prospectively enrolled. Patients underwent...
Piperacillin/tazobactam (PT), a widely utilized broad-spectrum antibiotic, has been associated with acute kidney injury (AKI). Although the precise mechanism remains uncertain, and most cases of PT-associated AKI are mild, this report describes rare severe complication PT, which manifested as necrotizing glomerulonephritis requiring hemodialysis. A 42-year-old man was transferred to nephrology clinic due progressive deterioration function. Prior transfer, patient had diagnosed appendicitis...
Various vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses histopathologic findings of new-onset diseases after vaccination as confirmed via biopsy. Five patients aged 42 77 years were included baseline function was normal all patients. The biopsy-proven diagnosis indicated newly diseases: (1) IgA nephropathy presenting with painless gross...
We tested the hypothesis that chronic treatment with sildenafil attenuates left ventricular (LV) remodeling and prevents exercise intolerance in mitral regurgitation (MR).MR was created Sprague-Dawley rats by making a hole on leaflet. Two weeks after MR creation, LV dilatation were confirmed echocardiography, randomly assigned to (MR+sildenafil group; 50 mg/kg PO twice day; n=16) or normal saline only (MR continued for 4 months. Sixteen sham compared rats. After months, size smaller...
The inhibitory effects of recombinant human erythropoietin (rhEPO) were examined against (1) the progression renal fibrosis in mice with complete unilateral ureteral obstruction and (2) TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) MDCK cells. Unilateral was induced BALB/c rhEPO (100 or 1000 U/kg, intraperitoneally, every other day) vehicle administered from day 3 to 14. Immunoblotting immunohistochemistry revealed increased expressions TGF-beta1, alpha-smooth muscle actin...
The effects of left ventricular (LV) loading conditions on LV dyssynchrony have not been elucidated. We modified to reveal their echocardiography-derived index (LVdys) in patients with documented nonischemic dilated cardiomyopathy.Thirty-seven were consecutively enrolled. After baseline measurements, pneumatic compression the lower extremities (Pcom) was used increase afterload. Subsequently, sublingual nitroglycerin (SL-NG) administered modify preload. Conventional echocardiographic...
The diagnosis of myocarditis traditionally relies on invasive endomyocardial biopsy but none the imaging studies so far are specific for infiltration inflammatory cells itself.We synthesized 68 Ga-2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA) by conjugating with mannose, followed conjugation NOTA and labeling it Ga.The efficacy Ga-NOTA-MSA positron emission tomography (PET) myocardial inflammation was tested in a rat...
Cardiac dysfunction is increasingly recognized in patients with liver cirrhosis. Nevertheless, the presence or absence of structural alterations such as diffuse myocardial fibrosis remains unclear. We aimed to investigate changes cirrhosis, and explore left ventricular (LV) functional induced by transplantation.
Purpose Lupus nephritis (LN) can be caused by the complement activation. This study aimed to investigate differences and clinical implications of activation pattern system for pediatric adult LN patients. Methods We retrospectively reviewed medical records 40 patients (14 26 patients) diagnosed with through kidney biopsy. Results The mean ages at diagnosis were 11.7±2.92 37.3±13.5 years, respectively. At first diagnosis, compared patients, had a higher estimated glomerular filtration rate...
Coumestrol (CMS), a coumestan isoflavone, plays key roles in nodulation through communication with rhizobia, and has been used as phytoestrogens for hormone replacement therapy humans. Because CMS content is controlled by multiple genetic factors, the basis of biosynthesis remained unclear. We identified soybean genotypes consistently high (Daewonkong) or low (SS0903-2B-21-1-2) over 2 years. performed RNA sequencing leaf samples from both at developmental stage R7, when levels are highest....
Heart failure (HF), particularly acute decompensated heart (ADHF), remains a significant health challenge, with limited long‐term therapeutic options to alleviate congestion and improve cardiac function. Pharmacological treatments focus on reducing congestion, but many patients are discharged persistent symptoms, leading poor outcomes. Current device‐based solutions, such as balloon catheters, offer some relief from fluid overload require hospitalization, driveline, direct blood contact,...
Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG composed of four acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, kidney injury. Oxalic the end product EG, which precipitate to crystals calcium oxalate monohydrate tubular lumen has been linked acute We report...
The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to lack studies limited research resources for this in Korea, we investigated patterns analyzing data from biopsies performed over 13 years university-based teaching hospital Korea.Among 2,053 2001 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed histopathologic, demographic, clinical as well laboratory results.Among the studied biopsies,...