A5034764661- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Bariatric Surgery and Outcomes
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Diet and metabolism studies
- Esophageal Cancer Research and Treatment
- Foreign Body Medical Cases
- Colorectal Cancer Screening and Detection
- Biliary and Gastrointestinal Fistulas
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Obesity and Health Practices
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Body Contouring and Surgery
- Minimally Invasive Surgical Techniques
- Radiomics and Machine Learning in Medical Imaging
- Blood transfusion and management
Asan Medical Center
2016-2025
University of Ulsan
2016-2025
Ulsan College
2016-2025
Versus Arthritis
2024
Konkuk University
2009-2017
Zero to Three
2017
Konkuk University Medical Center
2010-2016
National University College
2015
Yonsei University Health System
2015
National Institutes of Health
2015
microRNAs (miRNAs) play integral roles in diverse processes including tumorigenesis. miRNA gene loci are often found close conjunction, and such clustered genes transcribed from a common promoter to generate polycistronic primary transcript. The transcript (pri-miRNA) is then processed by two RNase III proteins release the mature miRNAs. Although it has been speculated that miRNAs same cluster may related biological functions, this not experimentally addressed. Here we report clusters...
PURPOSE Adjuvant chemotherapy after D2 gastrectomy is standard for resectable locally advanced gastric cancer (LAGC) in Asia. Based on positive findings perioperative European phase III studies, the PRODIGY study (ClinicalTrials.gov identifier: NCT01515748 ) investigated whether neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) followed by surgery adjuvant could improve outcomes versus treatment Korean patients with LAGC. PATIENTS AND METHODS Patients 20-75 years of age, Eastern Cooperative...
Early-onset gastric cancer, which develops in patients younger than most cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic cancers (DGCs) from patients.We conducted whole exome RNA sequence analyses 80 resected DGC samples 45 years old or Korea. Patients pathogenic germline mutations CDH1, TP53, ATM were excluded onset this...
JCO
Strong evidence is lacking as no confirmatory randomized controlled trials (RCTs) have compared the efficacy of totally laparoscopic distal gastrectomy (TLDG) with laparoscopy-assisted (LADG). The authors performed an RCT to confirm if TLDG different from LADG.
The purpose of this study is to investigate characteristics synchronous and metachronous cancer in gastric suggest appropriate methods treatment management.We reviewed 4,593 patients who underwent operations for at Seoul National University Hospital from 1999 2005. We selected those had also been diagnosed with another primary classified into three groups according the date detection cancer. analyzed their clinicopathological features.The incidence or addition was 3.4%. most common...
Abstract Background Preoperative accurate diagnosis of the T and N stages in early gastric cancer (EGC) is important determining application various limited treatments. The aim this study to analyze accuracy staging EGC with esophagogastroduodenoscopy (EGD), Stomach protocol CT (S‐CT), endoscopic ultrasonography (EUS), factors influencing accuracy. Methods Four hundred thirty‐four patients preoperatively diagnosed as using EGD or S‐CT undergoing curative gastrectomy at Seoul National...
<h3>Importance</h3> Acute isovolemic anemia occurs when blood loss is replaced with fluid. It often observed after surgery and negatively influences short-term long-term outcomes. <h3>Objective</h3> To evaluate the efficacy safety of ferric carboxymaltose to treat acute following gastrectomy. <h3>Design, Setting, Participants</h3> The FAIRY trial was a patient-blinded, randomized, phase 3, placebo-controlled, 12-week study conducted between February 4, 2013, December 15, 2015, in 7 centers...
The incidence of gallstones has been reported to increase after gastrectomy. However, few studies have conducted on the prevention gallstone formation in patients who undergone gastrectomy.To evaluate efficacy and safety ursodeoxycholic acid (UDCA) preventing gastrectomy with gastric cancer.The PEGASUS-D study (Efficacy Safety DWJ1319 Prevention Gallstone Formation Gastrectomy Patient Gastric Cancer: A Multicenter, Randomized, Double-blind, Placebo-controlled Study) was a randomized,...
Despite long-term survival reports in early gastric cancer, comparative life expectancy data with the general population is scarce. This study aimed to estimate patients' and analyze disparities between cancer patients population. Patients stage 1 who underwent curative gastrectomy at Asan Medical Center were enrolled. Survival status was tracked via national health insurance records. Life compared from Korean Statistical Information Service database. The cohort comprised 8,637 (64.7% men,...
Multidisciplinary treatment (MDT) in gastric cancer is an effective approach for establishing plans. However, the appropriateness of using "ratio MDT" as item evaluating adequacy Korea has not been previously researched. The purpose this study to verify whether appropriate evaluation from surgeon's perspective. This involved 142 patients who received MDT at our hospital between December 2015 and January 2023. Patients were divided into 2 groups based on date when was implemented; there 71...
This study aimed to define an optimal age cutoff for early-onset gastric cancer (EOGC) and compare its characteristics with those of late-onset (LOGC) using nationwide survey data. Using data from a survey, this comprehensive population-based analyzed spanning 3 years (2009, 2014, 2019). The joinpoint analysis interrupted time series (ITS) methodology were employed identify cutoffs EOGC based on the sex ratio tumor histology. Clinicopathologic surgical outcomes compared between LOGC groups....
Abstract Background The aim of this study was to investigate possible associations between (i) comorbid disease and (ii) perioperative risk factors morbidity following radical surgery for gastric cancer. Materials Methods Consecutive patients (759) undergoing gastrectomy D2 level lymph node dissection cancer were included. Clinical data concerning patient characteristics, operative methods, complications collected prospectively. Results rate 14.2% (108/759). most significant postoperative...
Current diagnostic markers for gastric cancer are not sufficiently specific or sensitive use in clinical practice. The aims of this study to compare the proteomes serum samples from patients with cancers and normal controls, develop useful tumor by quantitative proteomic analysis. We identified a total 388 proteins ≤1% FDR at least two unique peptides sera each group. Among them, 215, 251, 260 were an advanced group, early control respectively. selected differentially expressed compared...
The advantages of laparoscopic resection over open surgery in the treatment gastric gastrointestinal stromal tumor (GIST) are not conclusive. This study aimed to evaluate postoperative and oncologic outcome for GIST, compared surgery. We retrospectively reviewed prospectively collected database 1019 patients with GIST after surgical at 13 Korean 2 Japanese institutions. outcomes were between group, through 1:1 propensity score matching (PSM). group (N = 318) had a lower rate overall...
Mixed carcinoma shows a mixture of glandular and signet ring/poorly cohesive cellular histological components the prognostic significance each component is not fully understood. This study aimed to investigate poorly as risk factor for lymph node metastasis examine diagnostic reliability endoscopic biopsy. Clinicopathologic characteristics 202 patients who underwent submucosal invasive gastric resection with dissection in 2005-2012 were reviewed. accounted 27.2% (56/202) cases. The overall...
The aim of this study was to evaluate the treatment and prognosis gastric gastrointestinal stromal tumors (GISTs) according 7th UICC/AJCC tumor-node-metastasis (TNM) system modified National Institutes Health (NIH) risk classification. cohort consisted 1057 patients with GIST who underwent surgery between January 2000 December 2007 from 13 institutions in Korea 2 Japan. Clinicopathologic characteristics, surgical outcomes, recurrence, 5-year recurrence-free survival were evaluated. mean age...
BACKGROUND:In South Korea, which has a high incidence of gastric cancer, the most common de novo malignancy associated with liver transplantation is cancer. This study sought to identify clinicopathologic characteristics in cancer patients after transplantation, and help manage these cases. MATERIAL AND METHODS:We investigated at Asan Medical Center. We analyzed sex, age, cause initiating immunosuppressant, pre-transplantation fibroscopy findings, time interval between occurrence, follow-up...
Benign regional lymph nodes (LNs) are sometimes enlarged in gastric cancer patients due to reactive or inflammatory changes. Frequently these LNs can mimic LN metastasis and lead overstaging.To assess frequency of benign compared with that a healthy population the according T-staging.Between August 2005 June 2009, 177 surgically proven without (TanyN0M0) who had previously undergone preoperative multidetector row CT (MDCT) 168 visited healthcare center underwent an abdominal MDCT were...