A5039165896- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- Radical Photochemical Reactions
- Spondyloarthritis Studies and Treatments
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Rheumatoid Arthritis Research and Therapies
- Analytical Chemistry and Sensors
- Green IT and Sustainability
- Molecular Sensors and Ion Detection
- Gas Sensing Nanomaterials and Sensors
- Osteoarthritis Treatment and Mechanisms
- Fluorine in Organic Chemistry
- COVID-19 epidemiological studies
- Intracranial Aneurysms: Treatment and Complications
- Catalytic C–H Functionalization Methods
- Luminescence Properties of Advanced Materials
- Advanced Proteomics Techniques and Applications
- Sexual function and dysfunction studies
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 and Mental Health
- Catalytic Cross-Coupling Reactions
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
Kyung Hee University
2015-2025
Yonsei University
2002-2024
Pohang University of Science and Technology
2024
Mayo Clinic
2019-2023
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2020-2023
Severance Hospital
2010-2022
Kyungpook National University
2010-2022
Kyungpook National University Hospital
2018-2021
WinnMed
2019-2021
Herein we report a rational design strategy for tailoring intermolecular interactions to enhance room-temperature phosphorescence from purely organic materials in amorphous matrices at ambient conditions. The built-in strong halogen and hydrogen bonding between the newly developed phosphor G1 poly(vinyl alcohol) (PVA) matrix efficiently suppresses vibrational dissipation thus enables bright (RTP) with quantum yields reaching 24%. Furthermore, found that modulation of strength G1-PVA system...
Abstract Metal-free organic phosphorescent materials are attractive alternatives to the predominantly used organometallic phosphors but generally dimmer and relatively rare, as, without heavy-metal atoms, spin–orbit coupling is less efficient phosphorescence usually cannot compete with radiationless relaxation processes. Here we present a general design rule method effectively reduce transitions hence greatly enhance efficiency of metal-free in variety amorphous polymer matrices, based on...
The control of a reaction that can form multiple products is highly attractive and challenging concept in synthetic chemistry. A set valuable CF3 -containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, alkynes, were selectively generated from alkynes I by environmentally benign efficient visible-light photoredox catalysis. Subtle differences the combination catalyst, base, solvent enabled reactivity selectivity for between an alkyne I.
Abstract Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to-batch variation, high cost, safety issues. Here, we demonstrate that gastrointestinal tissue-derived hydrogels are suitable substitutes Matrigel in We found function gastric or intestinal grown comparable often superior those...
Abstract The highly sensitive optical detection of oxygen including dissolved (DO) is great interest in various applications. We devised a novel room‐temperature‐phosphorescence (RTP)‐based platform by constructing core–shell nanoparticles with water‐soluble polymethyloxazoline shells and oxygen‐permeable polystyrene cores crosslinked metal‐free purely organic phosphors. resulting show very high sensitivity for DO limit (LOD) 60 n m can be readily used quantification aqueous environments as...
Abstract Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, convenient method using visible light photoredox catalysis. A variety of unactivated were difluoroalkylated with ethyl 2‐bromo‐2,2‐difluoroacetate (BrCF 2 CO Et) the presence triscyclometalated Ir complex fac ‐[Ir(ppy) 3 ] under irradiation at room temperature. It is shown that reaction outcomes containing CF Et moiety...
Abstract Two transformations initiated by photoinduced one‐electron transfer to α‐bromo ketones have been demonstrated. Hantzsch esters donate one electron under photoirradiation, promoting reductive debromination. Subsequent reactions of the resulting radical species with molecular oxygen and lead α‐hydroxylation or debromination, respectively. The relative dominance two pathways depends profoundly on reaction conditions, including solvent, O 2 levels, concentration esters. synthetic...
Spurred by several recent discoveries and a broad largely unexplored design space, purely organic phosphorescent materials are starting to garner interest for potential applications in optoelectronics sensors. One particularly promising class of phosphor is the family consisting bromobenzaldehyde emitters doped into crystals dibromobenzene hosts. These stand out featuring bright, robust, color-tunable room temperature phosphorescence. However, despite these attractive qualities, mixed...
Abstract Herein we report a rational design strategy for tailoring intermolecular interactions to enhance room‐temperature phosphorescence from purely organic materials in amorphous matrices at ambient conditions. The built‐in strong halogen and hydrogen bonding between the newly developed phosphor G1 poly(vinyl alcohol) (PVA) matrix efficiently suppresses vibrational dissipation thus enables bright (RTP) with quantum yields reaching 24 %. Furthermore, found that modulation of strength...
Microvesicles (MVs, also known as exosomes, ectosomes, microparticles) are released by various cancer cells, including lung, colorectal, and prostate carcinoma cells. MVs from tumor cells other sources accumulate in the circulation pleural effusion. Although recent studies have shown that play multiple roles progression, potential pathological of MV effusion, their protein composition, still unknown. In this study, we report first global proteomic analysis highly purified derived human...
Abstract The control of a reaction that can form multiple products is highly attractive and challenging concept in synthetic chemistry. A set valuable CF 3 ‐containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, alkynes, were selectively generated from alkynes I by environmentally benign efficient visible‐light photoredox catalysis. Subtle differences the combination catalyst, base, solvent enabled reactivity selectivity for between an alkyne I.
To understand the pathophysiology of dry eye disease (DED), it is necessary to characterize proteins in ocular surface fluids, including tear fluid (TF) and lacrimal (LF). There have been several reports TF proteomes, but few proteomic studies examined LF secreted from gland (LG). Therefore, we characterized constituting by liquid chromatography mass spectrometry. were collected patients with non-Sjögren syndrome DED healthy subjects. Through protein profiling label-free quantification, 1165...
Alzheimer's disease (AD) is the most common form of dementia; however, at present time there no disease-modifying drug for AD. There increasing evidence supporting role lipid changes in process normal cognitive aging and etiology age-related neurodegenerative diseases. AD characterized by presence intraneuronal protein clusters extracellular aggregates β-amyloid (Aβ). Disrupted Aβ kinetics may activate intracellular signaling pathways, including tau hyperphosphorylation proinflammatory...
A synthetic route to achieve high phosphorescence quantum yield in a purely organic material was achieved by doping crystal containing heavy bromine atoms with molecule that contains triplet producing aromatic carbonyl group. The enhanced originated from intermolecular nonbonding interactions between the and oxygen. In this study we employ computational approach design molecules both structural motifs, which exhibit through intramolecular groups.
Abstract The photoredox catalytic coupling of halomethyl arenes to bibenzyl derivatives has been demonstrated. protocol employed the Hantzsch ester, potassium phosphate, and a photoactive cyclometalated Ir III complex catalyst. A photochemical quantum yield as high 20 % was obtained. mechanism investigated in detail by performing photophysical electrochemical measurements, well chemical calculations. results suggest that two‐electron mediation might be responsible for improved photon...
Abstract A simple and environmentally‐friendly synthetic method for benzimidazoles, which are important structural motifs in many applications owing to their various biological functions, has been developed. The reaction of o ‐phenylenediamine a variety aliphatic/aromatic aldehydes methanol proceeds at room temperature with only natural sources, molecular oxygen visible light.
Metal-free organic phosphorescent materials are promising alternatives to the organometallic counterparts predominantly adopted in light-emitting diodes due their low cost, chemical stability, and large molecular design window. However, only a few reports on OLED devices incorporating metal-free phosphors have been presented lack of understanding material properties, device physics, fabrication processes. Here, we report tailor-designed novel fluorene-based phosphor with efficient spin-orbit...
On March 15, 2020, 61.3% of the confirmed cases COVID-19 infection in South Korea are associated with worship service that was organized on February 9 Shincheonji Church Jesus Daegu. We aim to evaluate effects mass and assess preventive control intervention.Using openly available data daily cumulative deaths, basic effective reproduction numbers estimated using a modified susceptible-exposed-infected-recovered-type epidemic model.The number be R0=1.77. The increased approximately 20 times...
5-Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat colorectal cancer. 5-FU known gradually lose its efficacy in treating cancer following the acquisition of resistance. We investigated mechanism resistance using comprehensive lipidomic approaches. performed analysis on 5-FU-resistant (DLD-1/5-FU) and -sensitive (DLD-1) cells MALDI-MS LC-MRM-MS. In particular, sphingomyelin (SM) species were significantly up-regulated MALDI-TOF analysis. Further, we quantified sphingolipids...
Alzheimer's disease (AD) is the most common cause of dementia and associated with serious neurologic sequelae resulting from neurodegenerative changes. Identification markers early-stage AD could be important for designing strategies to arrest progression disease. The brain rich in lipids because they are crucial signal transduction anchoring membrane proteins. Cerebrospinal fluid (CSF) an excellent specimen studying metabolism it can reflect changes occurring brain. We aimed identify CSF...