A5017366532- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Gastrointestinal motility and disorders
- Regulation of Appetite and Obesity
- Sarcoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Erythropoietin and Anemia Treatment
- Inflammatory Biomarkers in Disease Prognosis
Sungkyunkwan University
2015-2024
Samsung Medical Center
2015-2024
American Society of Anesthesiologists
2020
Creative Commons
2020
Ghent University Hospital
2018
Samsung (United States)
2018
Samsung Medison (South Korea)
2018
Carrier (United States)
2016
Specifica (United States)
2016
Kim's Eye Hospital
2016
Purpose The ARTIST (Adjuvant Chemoradiation Therapy in Stomach Cancer) trial was the first study to our knowledge investigate role of postoperative chemoradiotherapy therapy patients with curatively resected gastric cancer D2 lymph node dissection. This designed compare treatment capecitabine plus cisplatin (XP) versus XP radiotherapy (XP/XRT/XP). Patients and Methods arm received six cycles (capecitabine 2,000 mg/m 2 per day on days 1 14 60 1, repeated every 3 weeks) chemotherapy. XP/XRT/XP...
The Adjuvant Chemoradiotherapy in Stomach Tumors (ARTIST) trial tested whether the addition of radiotherapy to adjuvant chemotherapy improved disease-free survival (DFS) patients with D2-resected gastric cancer (GC).Between November 2004 and April 2008, 458 GC who received gastrectomy D2 lymph node dissection were randomly assigned either six cycles capecitabine cisplatin (XP) or two XP followed by chemoradiotherapy then additional (XPRT). This final update contains first publication overall...
Adjuvant chemotherapy and chemoradiotherapy are some of the standards care for gastric cancer (GC). The chemoRadioTherapy In Stomach Tumors (ARTIST) 2 trial compares two adjuvant regimens in patients with D2-resected, stage II or III, node-positive GC.The ARTIST compared, a 1:1:1 ratio, three regimens: oral S-1 (40-60 mg twice daily 4 weeks on/2 off) 1 year, (2 on/1 week plus oxaliplatin 130 mg/m2 every 3 (SOX) 6 months, SOX 45 Gy (SOXRT). Randomization was stratified according to surgery...
Abstract The VIKTORY (targeted agent eValuation In gastric cancer basket KORea) trial was designed to classify patients with metastatic based on clinical sequencing and focused eight different biomarker groups (RAS aberration, TP53 mutation, PIK3CA mutation/amplification, MET amplification, overexpression, all negative, TSC2 deficient, or RICTOR amplification) assign one of the 10 associated trials in second-line (2L) treatment. Capivasertib (AKT inhibitor), savolitinib (MET selumetinib (MEK...
OBJECTIVES: Few studies have compared the long-term outcomes of endoscopic resection and surgery. The aim this study was to compare with those surgery for early gastric cancer (EGC). METHODS: We reviewed prospectively collected data patients who had undergone (1,290 patients) or (1,273 EGC. To reduce effect selection bias, we performed a propensity score-matching analysis between two groups. primary outcome overall survival (OS). secondary were disease-specific survival, disease-free (DFS),...
In Brief Objective: An accurate assessment of a potential lymph node metastasis is an important issue for the appropriate treatment early gastric cancer. Minimizing amount invasive procedures used in cancer critical improving patient's quality life. Therefore, this study analyzed predictive risk factors with submucosal invasion. Methods: The data from 1043 patients surgically treated invasion between 2002 and 2005 were reviewed retrospectively. divided into 3 layers according to their depth:...
In Brief Objective: Little is known about how quality of life (QOL) changes over time after gastrectomy. We prospectively examined QOL in Korean patients with gastric cancer curative resection. Background: As early detection and improved treatment have led to higher survival rates an increasing number long-term survivors, the importance has increased. Methods: Patients newly diagnosed cancer, who were expected undergo resection, studied. was assessed, using European Organization for Research...
Despite the benefits from adjuvant chemotherapy or chemoradiotherapy, approximately one-third of stage II gastric cancer (GC) patients developed recurrences. The aim this study was to develop and validate a prognostic algorithm for (GCPS) that can robustly identify high-risk group recurrence among patients. A multi-step gene expression profiling conducted. First, microarray archived paraffin-embedded tumor blocks used candidate genes (N = 432). Second, focused assay including robust clinical...
FGFR2 gene amplification, and resulting protein overexpression, is rare in gastric cancer patients, development of an accurate widely available method for mass screening to identify patients who may respond treatment with fibroblast growth factor receptor (FGFR) inhibitors important. We first screened 312 known copy number variations by FGFR2b immunohistochemistry using FPR2-D, isoform-specific antibody. Next, we performed on tissue microarrays from 1574 patients. Selected cases were...
Abstract Background and Objectives The correlation between perioperative CEA, CA 19‐9, 72‐4 recurrence of gastric cancer has not been clarified. aim this study was to investigate the relationships cancer. Methods We retrospectively analyzed tumor markers Results In patients with early cancer, sensitivity postoperative 40.0, 5.6, 2.8%, respectively. And in advanced 100.0, 68.2, 51.3%, Multivariate analyses showed that an increase CEA independent prognostic factor recurrence. age >60 years,...
Background/Aims: Gastric glomus tumors are extremely rare, and presurgical confirmation is often impossible.The identification of clinical radiologic characteristics this tumor type important for preoperative diagnosis treatment planning.Methods: In study, we analyzed 10 cases gastric resected at a single institute over 9 years.Results: Eight the patients were men 2 women, with mean age 49 years.Five presented abdominal discomfort or pain, 1 anemia, remaining 4 found incidentally during...
<h3>Importance</h3> Acute isovolemic anemia occurs when blood loss is replaced with fluid. It often observed after surgery and negatively influences short-term long-term outcomes. <h3>Objective</h3> To evaluate the efficacy safety of ferric carboxymaltose to treat acute following gastrectomy. <h3>Design, Setting, Participants</h3> The FAIRY trial was a patient-blinded, randomized, phase 3, placebo-controlled, 12-week study conducted between February 4, 2013, December 15, 2015, in 7 centers...
4001 Background: Adjuvant chemotherapy and/or chemoradiotherapy have been the standard of care in GC for years, supported by randomized trials. We compared efficacy different regimens and patients with D2-resected, stage II/III, node-positive GC. Methods: From Feb 2013 through Nov 2018, we randomly assigned, a 1:1:1 ratio, pathologically-staged II or III, node-positive, D2-resected GC, to receive adjuvant S-1 (40-60 mg twice daily 4-weeks-on/2-weeks-off) one year, (2-weeks-on/1-week-off)...
Programmed death-ligand 1 (PD-L1) is expressed in a subgroup of gastric cancers that may benefit from immunotherapy. Microsatellite instability-high (MSI-H) potential predictive factor for response to immunotherapy targeting the PD-1 or its ligand PD-L1. The relationship between PD-L1 expression and MSI-H status remains poorly understood. In this study, we investigated patients with cancer. We analyzed 78 cancer tissue samples using immunohistochemistry. was classified as on tumor cells...
Abstract Background The indications for endoscopic dissection have been expanded to improve the quality of life patients with early gastric cancer (EGC). This study aimed develop a nomogram predict status lymph node metastasis aim avoiding unnecessary gastrectomies. Methods We reviewed clinicopathological data 10 579 who underwent curative resection EGC. was developed by multivariate analysis and evaluated external validation. Overall, disease-free recurrence-free survival were compared...