A5080628294- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Ginseng Biological Effects and Applications
- Multiple Myeloma Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Asthma and respiratory diseases
- Animal Nutrition and Physiology
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Meat and Animal Product Quality
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Selenium in Biological Systems
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- Lipoproteins and Cardiovascular Health
- Mycotoxins in Agriculture and Food
- Gut microbiota and health
- Food Quality and Safety Studies
- Sinusitis and nasal conditions
- Wheat and Barley Genetics and Pathology
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2025
The University of Texas Health Science Center at Houston
2012-2024
Washington University in St. Louis
2018-2024
James S. McDonnell Foundation
2018-2024
Brown Foundation
2009-2024
Hubei Academy of Agricultural Sciences
2013-2024
Shanghai University of Traditional Chinese Medicine
2024
Yueyang Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Chinese Academy of Sciences
2011-2023
The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor A genome) represent a tool for studying complex, polyploid genomes should be valuable resource genetic improvement wheat. hexaploid bread aestivum, designated AABBDD, evolved as result hybridization between three ancestral grasses. Two papers published in issue Nature present sequences two these progenitors. First, T. (ancestor genome), which resembles cultivated more strongly than either Aegilops...
Triticum urartu (diploid, AA) is the progenitor of A subgenome tetraploid (Triticum turgidum, AABB) and hexaploid aestivum, AABBDD) wheat1,2. Genomic studies T. have been useful for investigating structure, function evolution polyploid wheat genomes. Here we report generation a high-quality genome sequence by combining bacterial artificial chromosome (BAC)-by-BAC sequencing, single molecule real-time whole-genome shotgun sequencing3, linked reads optical mapping4,5. We assembled seven...
The basic helix-loop-helix (bHLH) proteins are a large superfamily of transcription factors, and play central role in wide range metabolic, physiological, developmental processes higher organisms. Tomato is an important vegetable crop, its genome sequence has been published recently. However, the bHLH gene family tomato not systematically identified characterized yet.In this study, we 159 protein-encoding genes (SlbHLH) analyzed their structures. Although domains were conserved among between...
Abstract Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment propagation, affecting accuracy of modeling cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 matched patient (PT) samples from 509 models. CNA inferences based on DNA sequencing microarray data displayed substantially higher resolution...
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, transcriptomics cellular imaging. Subpopulations of tumor cells exhibited signatures proliferation, KRAS signaling, cell stress epithelial-to-mesenchymal transition. Mapping mutations copy number events distinguished populations normal transitional...
Background and Aims: Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated immunomodulatory short‐chain fatty acids (SCFAs) derived from intestinal microbiota ILC3 regulation. Approach Results: We report that Lactobacillus reuteri was markedly reduced gut mice with HCC, accompanied by decreased SCFA levels, especially acetate....
proprotein convertase subtilisin/kexin type 9 (PCSK9) negatively regulates the low-density lipoprotein (LDL) receptor (LDLR) in hepatocytes and therefore plays an important role controlling circulating levels of LDL-cholesterol. To date, relationship between PCSK9 metabolism apolipoprotein B (apoB), structural protein LDL, has been controversial remains to be clarified.We assessed impact overexpression (≈400-fold above baseline) on apoB synthesis secretion 3 mouse models: wild-type C57BL/6...
Background: Heat shock proteins (HSPs) are overexpressed in human hepatocellular carcinoma (HCC) tissue and correlate with aggressiveness prognosis of HCC.Methods: Using the GSE14520 microarray expression profile from Gene Expression Omnibus, we compared HSP gene between tumour non-tumour tissues correlated this outcomes HCC patients.Results: We analysed 220 hepatitis B virus (HBV)-related patients 25 HSPs study.With exception HSPA4L, HSPA12A HSPB8, members family, including HSPH1, HSPBP1,...
Abstract Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it still incurable as disease progression not fully understood. To investigate MM and its immune environment, we apply single cell RNA linked-read whole genome sequencing to profile 29 longitudinal samples at different stages from 14 patients. Here, collect 17,267 cells 57,719 cells, discovering patient-specific profiles expression changes. Patients with same...
Abstract Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established landscapes 536 patient-derived xenograft (PDX) models across 25 types, together mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared human tumors, PDXs typically higher purity fit dynamic driver events molecular properties via multiple...
Background The significance of the relationship between microbiota and diseases is increasingly being recognized. However, characterization tumor microbiome their precise molecular mechanisms through which promotes hepatocellular carcinoma (HCC) development are still unclear. Methods intrahepatic was investigated from tumor, normal adjacent tissues in 46 patients with HCC hepatic 33 hemangioma by 16S rRNA gene sequencing. Taxonomic composition differences were evaluated using Linear...
Breeding has dramatically changed the plant architecture of wheat (Triticum aestivum), resulting in development high-yielding varieties adapted to modern farming systems. However, how breeding shaped genomic this crop remains poorly understood. Here, we performed a comprehensive comparative analysis whole-genome resequencing panel 355 common accessions (representing diverse landraces and cultivars from China United States) at phenotypic levels. The genetic diversity was clearly reduced...
Tissue-specific gene expression is critical in understanding biological processes, physiological conditions, and disease. The identification appropriate use of tissue-specific genes (TissGenes) will provide important insights into disease mechanisms organ-specific therapeutic targets. To better understand the features for each cancer type to advance discovery clinically relevant or mutations, we built TissGDB (Tissue specific Gene DataBase cancer) available at http://zhaobioinfo.org/TissGDB....
Meat quality is one of the most important economic traits in pig breeding and production, intramuscular fat (IMF) content major factor improving meat quality. The IMF deposition pigs influenced by transcriptional regulation, which dependent on chromatin accessibility. However, how accessibility plays a regulatory role has not been reported. Xidu black composite breed with excellent quality, an ideal research object this study. In study, we used assay for transposase-accessible using...
Summary Histone modifications play critical roles in the perception of environmental cues by plants. Here, we report that S hk1 binding protein 1 ( SKB 1/ A t PRMT 5), which catalyzes symmetric dimethylation histone H 4 R 3 3sme2), is involved iron homeostasis Arabidopsis. The SKB1 lesion mutant exhibited higher accumulation shoots and greater tolerance to deficiency than wild type. expression was not affected iron, but level H4R3sme2 mediated related status We showed chromatin...
Abstract Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect fusions from cohort 742 patients Myeloma Research Foundation CoMMpass Study. Patients multiple clinic visits enable us track tumor and evolution, cases matching peripheral bone marrow samples allow evaluate concordance calls in high burden. We examine joint upregulation WHSC1 FGFR3 t(4;14)-related fusions,...
The objective of this study was to evaluate the ability a modified hydrated sodium calcium aluminosilicate (HSCAS) adsorbent reduce toxicity T-2 toxin in broilers. Ninety-six one-day-old male broilers were randomly allocated into four experimental groups with replicates six birds each. groups, 1–4, received basal diet (BD), BD plus 6.0 mg/kg toxin, 0.05% HSCAS adsorbent, and respectively, for two weeks. Growth performance, nutrient digestibility, serum biochemistry, small intestinal...
Central to genotoxic responses is their ability sense highly specific signals activate the appropriate repair response. We previously reported that activation of ASCC-ALKBH3 pathway exquisitely alkylation damage in human cells. Yet mechanistic basis for selectivity this was not immediately obvious. Here, we demonstrate RNA but DNA initiating signal process. Aberrantly methylated sufficient recruit ASCC, while an dealkylase suppresses ASCC recruitment during chemical alkylation. In turn,...
Powdery mildew, caused by Blumeria graminis f. sp. tritici, is one of the most important wheat diseases in world. In this study, a single dominant powdery mildew resistance gene MlIW172 was identified IW172 wild emmer accession and mapped to distal region chromosome arm 7AL (bin7AL-16-0.86-0.90) via molecular marker analysis. closely linked with RFLP probe Xpsr680-derived STS Xmag2185 EST markers BE405531 BE637476. This suggested that might be allelic Pm1 locus or new Pm1. By screening...