A5076934479- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Scientific Computing and Data Management
- Genomics and Rare Diseases
- Research Data Management Practices
- Chromosomal and Genetic Variations
- Advances in Oncology and Radiotherapy
- Genomics and Chromatin Dynamics
- Evolution and Genetic Dynamics
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Neurogenetic and Muscular Disorders Research
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Nutrition, Genetics, and Disease
- Kruppel-like factors research
Seven Bridges Genomics (United States)
2015-2024
Harvard University
2012-2019
Washington University in St. Louis
2019
Howard Hughes Medical Institute
2013-2018
Harvard Stem Cell Institute
2014-2018
Stanley Center for Psychiatric Research
2018
Broad Institute
2014
Tufts Medical Center
2007-2013
Harvard University Press
2013
Tufts University
2007-2012
microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use microRNA arrays to profile expression has indicated levels many altered disease. These findings have prompted a great deal investigation into mechanism function microRNA-mediated repression. However, mechanisms which govern regulation biogenesis activity just beginning be uncovered. Following...
In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells (VSMCs) in a "contractile" phenotype are required for normal regulation of tone. The transforming growth factor-β (TGF-β) superfamily factors (TGF-βs bone morphogenetic proteins (BMPs)) potent inducers contractile mediate (i) induction genes, (ii) inhibition VSMC migration. Transcription genes is positively regulated by regulatory DNA element called CArG box. box activated binding serum response...
Abstract Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment propagation, affecting accuracy of modeling cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 matched patient (PT) samples from 509 models. CNA inferences based on DNA sequencing microarray data displayed substantially higher resolution...
MicroRNAs (miRNAs) are small, noncoding RNAs that influence diverse biological outcomes through the repression of target genes during normal development and pathological responses. In particular, alteration miRNA expression has dramatic consequences for progression tumorigenesis. miRNAs undergo two processing steps transform a long primary transcript into mature miRNA. Although general biogenesis pathway is well established, it clear not all created equally. Recent studies show controlled by...
The Seven Bridges Cancer Genomics Cloud (CGC; www.cancergenomicscloud.org) enables researchers to rapidly access and collaborate on massive public cancer genomic datasets, including Genome Atlas. It provides secure on-demand data, analysis tools, computing resources. Researchers from diverse backgrounds can easily visualize, query, explore datasets visually or programmatically. Data of interest be immediately analyzed in the cloud using more than 200 preinstalled, curated bioinformatics...
Vascular smooth muscle cells (VSMCs), unlike other cells, do not terminally differentiate. In response to injury, VSMCs change phenotype, proliferate, and migrate as part of the repair process. Dysregulation this plasticity program contributes pathogenesis several vascular disorders, such atherosclerosis, restenosis, hypertension. The discovery mutations in gene encoding BMPRII, type II subunit receptor for bone morphogenetic proteins (BMPs), patients with pulmonary arterial hypertension...
Hypoxia contributes to the pathogenesis of various human diseases, including pulmonary artery hypertension (PAH), stroke, myocardial or cerebral infarction, and cancer. For example, acute hypoxia causes selective (PA) constriction elevation pressure. Chronic induces structural functional changes vasculature, which resembles phenotype PAH is commonly used as an animal model this disease. The mechanisms that lead hypoxia-induced phenotypic have not been fully elucidated. Here, we show...
Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has elucidated. Population studies revealed that the variant rs5068 (A/G) in 3′ untranslated region of NPPA, gene encoding atrial natriuretic peptide (ANP), is associated with pressure. We selected individuals on basis genotype (AG vs. AA) and fed them a low- or high-salt diet for 1 week, after which they were challenged an intravenous saline infusion. On both diets, before administration, ANP...
Abstract The NCI's Cloud Resources (CR) are the analytical components of Cancer Research Data Commons (CRDC) ecosystem. This review describes how three CRs (Broad Institute FireCloud, for Systems Biology Gateway in Cloud, and Seven Bridges Genomics Cloud) provide access availability to large, cloud-hosted, multimodal cancer datasets, as well offer tools workspaces performing data analysis where resides, without download or storage. In addition, users can upload their own into workspaces,...
Bone morphogenetic protein (BMP) signaling regulates many different biological processes, including cell growth, differentiation, and embryogenesis. BMPs bind to heterogeneous complexes of transmembrane serine/threonine (Ser/Thr) kinase receptors known as the BMP type I II (BMPRI BMPRII). BMPRII phosphorylates activates BMPRI kinase, which in turn Smad proteins. The cytoplasmic region contains a "tail" domain (BMPRII-TD) with no enzymatic activity or regulatory function. discovery mutations...
Abstract More than ever, scientific progress in cancer research hinges on our ability to combine datasets and extract meaningful interpretations better understand diseases ultimately inform the development of treatments diagnostic tools. To enable successful sharing use big data, NCI developed Cancer Research Data Commons (CRDC), providing access a large, comprehensive, expanding collection data. The CRDC is cloud-based data science infrastructure that eliminates need for researchers...
The signaling pathway mediated by BMPs plays an essential role during development as well the maintenance of homeostasis in adult. Aberrant activation or inactivation BMP can lead to developmental defects and various human disorders. To fine-tune its activity, is regulated both positively negatively extrinsic intrinsic regulatory factors that modulate binding ligand receptors, activity receptors their dedicated signal transducers, Smad proteins. Upon receptor complex, proteins translocate...