A5076794062- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Animal Nutrition and Physiology
- Cardiovascular Disease and Adiposity
- Muscle Physiology and Disorders
- bioluminescence and chemiluminescence research
- Meat and Animal Product Quality
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- Agriculture, Soil, Plant Science
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Biochemical Analysis and Sensing Techniques
- COVID-19 epidemiological studies
- Molecular Biology Techniques and Applications
Australian National University
2022-2024
Shanghai Jiao Tong University
2019-2021
Meat quality is one of the most important economic traits in pig breeding and production, intramuscular fat (IMF) content major factor improving meat quality. The IMF deposition pigs influenced by transcriptional regulation, which dependent on chromatin accessibility. However, how accessibility plays a regulatory role has not been reported. Xidu black composite breed with excellent quality, an ideal research object this study. In study, we used assay for transposase-accessible using...
Summary Intramuscular fat (IMF) is an important meat‐quality trait of pigs, which influences pork’s shearing force, hydraulics, tenderness and juicy flavor. However, to achieve a higher percentage lean meat, pigs with lower backfat thickness (BF) are intensively selected for, may lead reduction in pork quality. Therefore, the objective this study was locate loci that affect IMF without changing BF. A single‐step GWAS performed on 950 Duroc genotyped by 50K SNP chip order detect genomic...
Abstract Background Jianli pig, a renowned indigenous breed in China, has the characteristics of two-end black (TEB) coat color, excellent meat quality, strong adaptability and increased prolificacy. However, there is limited information available regarding genetic diversity, population structure genomic regions under selection pig. On other hand, mechanism TEB color remained largely unknown. Results In this study, whole genome resequencing 30 pigs within context 153 individuals representing...
Most indigenous pig resources are known to originate from China. Thus, establishing conservation priorities for these local breeds is very essential, especially in the case of limited funds. Therefore, this study, we analyzed 445 individuals belonging six Taihu Lake Region, using a total 131,300 SNPs. In order determine long-term guidelines management breeds, level diversity metapopulation following partition within and between breed subpopulations, both measures genic allelic diversity....
Since late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly evolved to become a global pandemic. Each country was affected but with varying number of infected cases and mortality rates. Africa hit pandemic rose sharply. In this study, we investigated 224 SARS-CoV-2 genome sequences from Global Initiative on Sharing Avian Influenza Data (GISAID) in early part which 69 were Africa. We analyzed total 550 mutations comparing them reference sequence Wuhan....
The primary purpose of the current study was to assess genetic diversity, runs homozygosity (ROH) and ROH islands in a Chinese composite pig explore hotspot regions for traces selection. First, we estimated length, number, frequency 262 Xidu black pigs using Porcine SNP50 BeadChip compared estimates inbreeding coefficients, which were calculated based on ROHs (F ) HOM ). Our result shows that total 7,248 exceeding 1Mb detected pigs. In addition, Sus scrofa chromosome (SSC) 8 SSC10,...
Abstract Background China is the country with most abundant swine genetic resources in world. Through thousands of years domestication and natural selection, pigs have developed unique characteristics. Finding characteristics modules each breed an essential part their precise conservation. Results In this study, we used partial least squares method to identify significant specific SNPs 19 local Chinese pig breeds 5 Western breeds. A total 37,514 ( p < 0.01) were obtained from these...
Porcine skeletal muscle development is closely linked to meat production efficiency and quality. The accumulation of porcine intramuscular fat influenced by the hyperplasia hypertrophy adipocytes within muscle. However, cellular profiles corresponding two stages remain undetermined. Single-nucleus RNA sequencing (snRNA-seq) can elucidate cell subsets in tissues, capture gene expression at individual level, provide innovative perspectives for studying formation. In this study, a total 78,302...
The Jiangquhai (JQ) pig breed is one of the most widely recognized population in China due to its unique and dominant characteristics. In this study, we report extent Linkage disequilibrium (LD) haplotype block structure JQ scanned blocks for possible genes underlying important QTLs that could either be responsible some adaptive features these pigs or might have undergone selection pressure. We compared our results with other Chinese Western breeds. show had highest total length (349.73...
Gene expression programs underpin the development of shared phenotypes, yet importance transcript complexity in shaping mammalian evolution remains unclear. Here we present a comprehensive long-read direct RNA sequencing atlas full-length transcripts and their m6A modifications across six tissues (hippocampus, frontal cortex, cerebellum, testes, skeletal muscle, liver) five mammals (human, mouse, rat, dog, cow) non-mammalian out-group (chicken). Our analysis reveals that 29% genes have...
Enhancers, as the genomic non-coding sequences, play a key role in activation of gene expression. They have been widely identified human genome. Pig is an important biomedical model for health. Few studies performed to explore enhancers pig The enhancer information may be useful identify In addition, genetic background traits could annotate and diseases. Thus, order further study their potential roles pig, we developed public database, ETph (Enhancers Targets human). integrates on enhancers,...
Pituitary Specific transcription factor 1 (PIT-1) gene is one of the POU family and play key roles in regulation muscle development which important for body weight chickens. This study was carried out to detect polymorphism PIT-1 its association with Fulani Yoruba ecotype Nigerian indigenous A total 100 day-old chicks comprising fifty ecotypes were used this study. These genotyped using PCR-RFLP technique their growth rate also measured throughout Our results showed two alleles B controlling...
Abstract Background: Jianli pig, a renowned indigenous breed in China, has the characteristics of two-end black (TEB) coat color, excellent meat quality, strong adaptability and increased prolificacy. However, there is limited information available regarding genetic diversity, population structure genomic regions under selection pig. On other hand, mechanism TEB color remained largely unknown. Results: In this study, whole genome resequencing 30 pigs within context 153 individuals...