A5046974770- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Vitamin D Research Studies
- Assisted Reproductive Technology and Twin Pregnancy
- RNA modifications and cancer
- Reproductive Health and Technologies
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- TGF-β signaling in diseases
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- COVID-19 Impact on Reproduction
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- Ovarian cancer diagnosis and treatment
- Angiogenesis and VEGF in Cancer
University at Albany, State University of New York
2023-2024
Iowa State University
2022-2023
Cancer Research Center
2023
Chongqing Medical University
2019-2022
Chongqing Public Health Medical Center
2019-2022
Kwame Nkrumah University of Science and Technology
2022
Children's Hospital of Chongqing Medical University
2022
Ministry of Education of the People's Republic of China
2020-2021
University of Cape Coast
2020-2021
Abstract The placenta is an essential organ that supports the growth and development of fetus during pregnancy. However, cell type-specific enhancers transcription factors (TFs), mechanisms underlying maintenance differentiation trophoblast stem (TSC) populations in human remain elusive. Here, using TSCs as a model system, we identify 31,362 are enriched with motifs previously reported TSC-pivotal TFs, including TEAD4, GATA2/3 TFAP2C. Subsequently, 580 super-enhancers (SEs) 549 SE-associated...
Bisphenol A (BPA), an endocrine-disrupting chemical, is used to produce a wide variety of plastic and common house-hold items. Therefore, there potential continual exposure this compound. BPA has been linked certain placenta-associated obstetric complications such as preeclampsia, fetal growth restriction, miscarriage, preterm birth. However, how results in these disorders remains uncertain. Hence, we have herein summarized the reported impacts on morphology metabolic state placenta proposed...
Abstract As the first long noncoding RNA to be discovered, H19 has gained substantial attention as a key regulator of several biological processes and its roles in female reproductive biology are gradually getting revealed. Herein, we have summarized current evidence regarding expression pattern involvement developmental pathological associated with ovary placenta. The findings indicate that within ovaries, is expressed antral cystic atretic follicles well corpora lutea but absent...
Preeclampsia is a pregnancy complication which threatens the survival of mothers and fetuses. It originates from abnormal placentation, especially insufficient fusion cytotrophoblast cells to form syncytiotrophoblast. In this study, we found that THBS1, matricellular protein mediates cell-to-cell cell-to-matrix interactions, downregulated during primary BeWo cells, but upregulated in placenta pregnancies complicated by preeclampsia. Also, THBS1 was observed interact with CD36, membrane...
Preeclampsia is a major cause of maternal and neonatal morbidity mortality in sub-Saharan Africa. Evidence indicates that endothelial dysfunction central to the pathogenesis preeclampsia. This study assessed level components arginine-nitric oxide pathway evaluate normotensive pregnancies complicated with preeclampsia.This case-control was conducted among pregnant women who visited Comboni Hospital from January 2017 May 2018. A total 180 comprising 88 preeclamptic (PE) 92 healthy (NP) were...
The aim of this study was to determine the impact glycyrrhizin, an inhibitor high mobility group box 1, on glucose metabolic disorders and ovarian dysfunction in mice with polycystic ovary syndrome. We generated a syndrome mouse model by using dehydroepiandrosterone plus high-fat diet. Glycyrrhizin (100 mg/kg) intraperitoneally injected into effects body weight, tolerance, insulin sensitivity, estrous cycle, hormone profiles, pathology, glucolipid metabolism, some molecular mechanisms were...
Since late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly evolved to become a global pandemic. Each country was affected but with varying number of infected cases and mortality rates. Africa hit pandemic rose sharply. In this study, we investigated 224 SARS-CoV-2 genome sequences from Global Initiative on Sharing Avian Influenza Data (GISAID) in early part which 69 were Africa. We analyzed total 550 mutations comparing them reference sequence Wuhan....
Breast cancer (BRCA) is one of the most common cancers in women worldwide and a leading cause death from malignancy. This study was designed to identify novel biomarker for prognosticating survival BRCA patients.The prognostic potential eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) assessed using RNA sequencing (RNA-seq) data The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) as training cohort validation set, respectively. functional enrichment analysis...
In frozen embryo transfer (FET), there is limited consensus on the best means of endometrial preparation in terms reproductive outcomes women with polycystic ovary syndrome (PCOS). The present study aimed to compare pregnancy and neonatal following artificial cycle FET (AC-FET) or without gonadotropin-releasing hormone agonist (GnRH-a) pretreatment among PCOS.A total 4503 cycles that satisfied inclusion criteria were enrolled this retrospective cohort between 2015 2020. GnRH-a group received...
This cohort study assesses the association of maternal hepatitis B virus (HBV) serostatus with pregnancy outcomes in women undergoing freeze-thaw embryo transfer (FET).
Abstract Background Hypovitaminosis D in pregnancy is associated with adverse health outcomes mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin [25(OH)D] normotensive pregnancies preeclampsia, evaluated association between vitamin deficiency preeclampsia risk; determined foeto-maternal outcome preeclamptic women deficiency. Methods case-control was conducted among pregnant who visited Comboni Hospital, Ghana from January 2017 to May 2018 for antenatal care. A...
The syncytiotrophoblast, derived from cytotrophoblast fusion, is responsible for maternal-fetal exchanges, secretion of pregnancy-related hormones, and fetal defense against pathogens. Inadequate fusion can lead to pregnancy disorders, such as preeclampsia growth restriction. However, little known about the mechanism in both physiological pathological conditions. In this study, P57kip2 (P57), a cell cycle-dependent kinase inhibitor that negatively regulates cycle, was found be up-regulated...