Abstract Background Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via evolution. It may be possible overcome treatment resistance by developing a personalized approach against relapsing cancers based on comprehensive analysis of cell type-specific transcriptomic changes over clinical course disease using single-cell RNA sequencing (scRNA-seq). Methods Here, we used scRNA-seq depict landscape single case...

Although the standard treatment for patients with recurrent and metastatic prostate cancer (CaP) is androgen deprivation therapy, castration-resistant (CRPC) eventually emerges. Our previous report indicated that bone morphogenetic protein 6 (BMP6) induced CRPC via tumour-infiltrating macrophages. In a separate line of study, we have observed WNT5A/BMP6 loop in CaP metastasis mediates resistance to tissue culture. Simultaneously, reported BMP6 castration cells Therefore, our present study...

Curcumin is a nontoxic, chemopreventive agent possessing multifaceted functions. Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/β-catenin signaling in LNCaP cells. Therefore, we investigated the vivo effects by using xenografts.LNCaP cells were subcutaneously inoculated Balb/c nude mice. When tumor volume reached greater than 100 mm(3), either (500 mg/kg body weight) or vehicle was administered oral gavage three times weekly for 4 weeks. The...

Although androgen deprivation therapy (ADT) and immunotherapy are potential treatment options in men with metastatic prostate cancer (CaP), has conventionally been proposed to be a suppressor of the immune response. However, we herein report that DHT activates macrophages. When murine macrophage cell line (RAW 264.7), human monocyte (THP-1), peripheral blood monocytes were cultured androgen-resistant CaP lines, increased cytotoxicity macrophages concentration-dependent manner. Further...

We evaluated the long-term efficacy of laparoscopic Burch colposuspension for stress urinary incontinence (SUI) in women. A total 68 patients who underwent extraperitoneal colposuspensions with more than a 3-yr follow-up were included. The was performed by using two non-absorbable sutures on each side. considered to be cured SUI if they had negative result cough test and there no reports urine leakage during physical stress. mean period 52 months (range, 36 83 months). overall subjective...

We describe what is to our knowledge the first case of xanthogranulomatous pyelonephritis combined with nephrocutaneous fistula caused by Providencia rettgeri. Surgical extirpation including nephrectomy and fistulectomy was successfully performed. The strain identified 16S rRNA gene sequencing in both renal tissue pus culture from fistula.

To identify the effects of overactive bladder (OAB) symptoms on health-related quality life (HRQOL) in stroke patients since OAB are common such patients, but their rehabilitation over time unclear.This study included 30 post-acute who had been admitted for treatments. All participants completed a questionnaire evaluating urinary symptoms, including Overactive Bladder Symptom Score (OABSS) and general HRQOL with Short-Form 36 (SF-36) health survey. We assessed performance terms Function...

Penile length (PL) shortening is an underreported phenomenon following radical prostatectomy (RP) and risk factors are not fully explored. We aimed to describe longitudinal patterns of PL recovery evaluate predicting complete return baseline PL.PL measurement was performed during a preoperative postoperative follow-up visits at 7 days 3, 6, 9, 12 months. Patients who completely recovered (CR: N = 397) their stretched measured least one were compared those with incomplete (IR: 131). Recovery...

Bladder cancer exhibits a broad spectrum of heterogenous clinical behavior. Conventionally used clinicopathological factors are associated with certain limitations regarding the accurate prediction outcome. Recent studies have focused on predictive role cellular regulatory markers. The present case aimed to describe an extremely rare non-muscle invasive bladder (NMIBC) patient early isolated bone metastases following curative surgery. An assessment alterations biomarkers using...

A major problem diagnosing bladder cancer using conventional white-light cystoscopy is that flat and tiny papillary neoplasms can be overlooked. Fluorescence based on the detection of protoporphyrin IX (PpIX)-induced fluorescence in urothelial through topical administration 5-aminolevulinic acid (ALA). The diagnostic efficacy was evaluated this study. focus investigation to ascertain whether could make a contribution staging improving choice adjuvant therapy after transurethral resection.A...

Theranostics is a new term which involves the integration of therapy and diagnosis in single platform. Prostate-specific membrane antigen (PSMA) has emerged to be novel promising target for both diagnostic imaging therapeutics prostate cancer. During past decade, radiotracers targeting PSMA positron emission tomography (PET) have been developed. These PET tracers are small molecular inhibitors that bind extracellular domain PSMA. With recent approval radioisotope labeled clinical use, field...

Purpose: Laparoscopic donor nephrectomy is associated with decreased morbidity while maintaining similar graft function in short-term follow-up compared open surgery. We investigated hand-assisted laparoscopic (HALDN) comparison standard (ODN) living donors. Patients and Methods: Two hundred patients who received a living-donor kidney were followed up for more than 1 year enrolled. The procedure was performed exclusively on the left through either HALDN or ODN from January 2001 to July 2004....

Since the renal epidermoid cyst is too rare, mechanisms of squamous morphogenesis have not well characterized. A 73-year-old female was referred with an incidentally detected pelvis mass. Abdominopelvic computed tomography scan revealed a noncalcified soft tissue mass in pelvis. Total nephroureterectomy performed under impression malignancy. The patient discharged without postoperative complication. outer surface lesion lined urothelia and epithelia, containing keratinous materials. were...

There is little data evaluating the changes of severity bladder outlet obstruction after 80 W-potassium-titanyl-phosphate (KTP) photoselective laser vaporization prostatectomy (PVP) by pressure-flow study. We evaluated efficacy PVP to relieve in benign prostate hyperplasia (BPH) compared with transurethral resection (TURP).This a prospective, non-randomized single center The inclusion criteria were as follows: Men suffering from lower urinary tract symptoms (LUTS) secondary BPH, age ≥50...

The present study aimed to evaluate changes in mRNA and protein expression levels of α1-AR before after doxazosin treatment.This 12-month, prospective included males aged 50 or older who had lower urinary tract symptoms (LUTS) (International Prostate Symptom Score [IPSS] ≥ 8) with benign prostatic hyperplasia (BPH). All patients underwent transrectal ultrasound-guided prostate biopsy 4 mg medication for 12 months. were analyzed using real-time quantitative reverse transcription-polymerase...

Mountain-cultivated ginseng (MCG) is a very important health functional material in Korea and the USA. In this study, growth saponin of MCG change according to sowing method were investigated. Six methods natural cultivation that grows Sancheong mountain farm Germination rate budding different method. The characteristics also Among six methods, length leaves was widest BFS. width wide DFS DS. weight shoot heaviest BFS, DF lightest. Root diameter highest BFS covering both fallen soil. Total...

The fate of testicular salvage in spermatic cord torsion depends on the duration ischemia and degree torsion.Even though (SCT) can occur at any age, it is rarely reported older patients.If physician does not pay close attention to this unusual situation, lack suspicion for SCT may result a missed or delayed diagnosis.We report very uncommon case occurring 63-year-old man.

The hormonal sensitivity of prostate cancer has been exploited clinically since Huggins and Hodges established the suppressive effects castration on cancer. Despite over sixty years research into alternate modalities, androgen deprivation therapy (ADT) become mainstay treatment for locally advanced metastatic Suppression testosterone production, primary goal therapy, can be achieved by a multitude treatments. ideal timing, duration composition ADT remains undefined. At present time,...

You have accessJournal of UrologyModerated Poster 57, Wednesday, May 23, 2007 1:00 - 3:00 pm1 Apr 20071840: Impact 80 Watt KTP Photoselective Laser Vaporization Prostatectomy versus Transurethral Resection the Prostate on Volume and Severity Obstruction: 6-Month Results a Prospective Trial Deok Hyun Han, Jin Woo Chung, Ji Young Kim, Byung Joo Jung, Jeong Hee Hong, Sung Won Lee HanDeok Han More articles by this author , ChungJin Chung KimJi Kim JungByung Jung HongJeong Hong LeeSung View All...