A5057845598- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Brain Metastases and Treatment
- Chemical Reactions and Isotopes
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Click Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- 3D Printing in Biomedical Research
- Congenital Diaphragmatic Hernia Studies
- RNA Interference and Gene Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
- Wound Healing and Treatments
- FOXO transcription factor regulation
- Occupational exposure and asthma
- Occupational and environmental lung diseases
- Cancer Mechanisms and Therapy
- Metastasis and carcinoma case studies
Catholic University of Korea
2005-2024
Yeouido St. Mary's Hospital
2022-2024
Samsung Medical Center
2013-2023
Sungkyunkwan University
2013-2017
St. Vincent's Hospital
2015
Samsung (South Korea)
2013
Gwangju Institute of Science and Technology
2012
Abstract Background Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral impacts therapeutic outcome remain poorly understood. RNA sequencing (RNA-seq) of single tumor cells can provide comprehensive information about gene expression single-nucleotide variations in individual cells, may allow for translation heterogeneous cell responses into customized anti-cancer treatments. Results We isolated 34...
Glioblastoma (GBM) is the most aggressive and lethal brain tumor. As current standard therapy consisting of surgery chemo-irradiation provides limited benefit for GBM patients, novel therapeutic options are urgently required. Forkhead box M1 (FoxM1) transcription factor an oncogenic regulator that promotes proliferation, survival, treatment resistance various human cancers. The roles FoxM1 in remain incompletely understood, due part to pleotropic nature pathway. Here, we show stem cell...
Contemporary cancer therapy refers to treatment based on genetic abnormalities found in patient's tumor. However, this approach is faced with numerous challenges, including tumor heterogeneity and molecular evolution, insufficient samples available along information linking clinical outcomes, lack of therapeutic drugs containing pharmacogenomic information, technical limitations rapid drug efficacy tests quantities primary cells from patients. To address these problems improve outcomes...
Background and Purpose T oll‐like receptors ( TLRs ) play a crucial role in recognizing invading pathogens endogenous danger signal to induce immune inflammatory responses. Since dysregulation of enhances the risk disorders chronic diseases, modulation TLR activity by phytochemicals could be useful therapeutically. We investigated effect caffeic acid phenethyl ester CAPE on ‐mediated inflammation underlying regulatory mechanism. Experimental Approach Inhibitory effects TLR4 activation were...
Abstract Purpose: The increasing prevalence of distant metastases from non–small cell lung cancer (NSCLC) indicates an urgent need for novel therapeutic modalities. Brain metastasis is particularly common in NSCLC, with severe adverse effects on clinical prognosis. Although the molecular heterogeneity NSCLC and availability various targeted agents suggest personalized approaches such brain metastases, further development appropriate preclinical models needed to validate strategies....
Abstract Background Although temozolomide (TMZ) has been used as a standard adjuvant chemotherapeutic agent for primary glioblastoma (GBM), treating isocitrate dehydrogenase wild-type (IDH-wt) cases remains challenging due to intrinsic and acquired drug resistance. Therefore, elucidation of the molecular mechanisms TMZ resistance is critical its precision application. Methods We stratified 69 IDH-wt GBM patients into TMZ-resistant ( n = 29) sensitive 40) groups, using screening corresponding...
Despite extensive efforts on the genomic characterization of gliomas, very few studies have reported genetic alterations cerebellar glioblastoma (C-GBM), a rare and lethal disease. Here, we provide systematic study C-GBM to better understand its specific features.We collected cohort patients compared patient demographics tumor pathologies with supratentorial (S-GBM). To uncover molecular characteristics, performed DNA mRNA sequencing methylation arrays 19, 6, 4 cases, respectively. Moreover,...
Abstract Background Gastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, clinical translation molecular-guided targeted therapy hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating development effective treatments. Methods To address such challenges, we established a comprehensive...
// Dong Geon Kim 1, 2 , Kang Ho Yun Jee Seo Heekyoung Yang 2, 3 Eric G. Marcusson 6 Eunju Son 4 Kyoungmin Lee Jason K. Sa Hye Won 5 Do-Hyun Nam 1 Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea Institute for Refractory Cancer Research, Samsung Medical Center, Neurosurgery, University School Medicine, Anatomy Cell Biology, Urology, Providence Therapeutics, Calgary, Canada Correspondence to: Nam, email: nsnam@skku.edu Keywords: anti-miR,...
Objectives While endoscopic resection of rectal neuroendocrine tumors (NETs) has significantly increased, long-term data on risk factors for recurrence are still lacking. Our aim is to analyze the outcomes patients with NETs after through stratification.
The limiting dilution assay (LDA) is a clonogenic drug efficacy test designed to determine value for based on an all‐or‐none (positive or negative) response within replicates. It also attempts calculate minimum cell numbers cells form colony in each drugged conditions, wherein large implies high (as number of extant are required start colony). However, traditional LDAs time‐consuming set up, often requiring many replicates statistical analysis, and manual identification under microscope...
Abstract Background Gynecologic malignancy is one of the leading causes mortality in female adults worldwide. Comprehensive genomic analysis has revealed a list molecular aberrations that are essential to tumorigenesis, progression, and metastasis gynecologic tumors. However, targeting such alterations frequently led treatment failures due underlying complexity simultaneous activation various tumor cell survival pathway molecules. A compilation characterization tumors with pharmacological...
Targeted next-generation sequencing (NGS) panels for solid tumors have been useful in clinical framework accurate tumor diagnosis and identifying essential molecular aberrations. However, most cancer designed to address a wide spectrum of pan-cancer models, lacking integral prognostic markers that are highly specific gliomas.To such challenges, we developed glioma-specific NGS panel, termed "GliomaSCAN," is capable capturing single nucleotide variations insertion/deletion, copy number...
Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels have been observed in several disease models. The involvement some Bcl-2-binding proteins differentiation has recently reported. However, relevance to cellular remains unknown. findings herein show that expression is up-regulated during HL-60 cells. To investigate effect on differentiation, we established Bis-overexpressing cells (HL-60-bis). HL-60-bis low nuclear: cytoplasmic...
Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare, recently classified entity that consists of pleural and subjacent parenchymal fibrosis predominantly in the upper lungs. In an official American Thoracic Society/European Respiratory Society statement 2013, this disease introduced as group rare idiopathic interstitial pneumonias. We describe case 76-year-old woman with cough recurrent pneumothorax. She was admitted to our hospital severe at first. High resolution computed...
Diffusely infiltrating gliomas (DIGs) are difficult to completely resect and associated with a high rate of tumor relapse progression from low- high-grade glioma. In particular, optimized short-term culture-enriching patient-derived glioma stem cells (GSCs) essential for customizing the therapeutic strategy based on clinically feasible in vitro drug screening wide range DIGs, owing inter-tumoral heterogeneity. Herein, we constructed novel high-throughput culture condition platform called...
See the Erratum "Intrathoracic kidney with left-sided Bochdalek hernia in a woman bacteremic acute pyelonephritis due to Escherichia coli" on page 421.
505 Background: The detection of rectal neuroendocrine tumors has increased with advances in diagnostic endoscopy. Endoscopic resection (ER) is highly effective treatment option for small (NETs) confined to submucosa. However, there was no risk classification evaluating the clinical outcomes. In this study, we analyzed long-term outcomes after ER. Methods: multicenter retrospective medical records patients who underwent ER NETs from 2009 2018 and were followed ≥ 12 months at five university...
저자들은 대동맥활에 발생하고 종격동, 흉강, 심장막에 광범위한 화농성 합병증을 동반한 비장티푸스성 살모넬라 감염에 의한 감염성 거짓 동맥류 1예를 경험하고 치료하였기에 보고하는 바이다. 중심 단어: 거짓동맥류; 종격동염; 심낭염;
<div>Abstract<p><b>Purpose:</b> The increasing prevalence of distant metastases from non–small cell lung cancer (NSCLC) indicates an urgent need for novel therapeutic modalities. Brain metastasis is particularly common in NSCLC, with severe adverse effects on clinical prognosis. Although the molecular heterogeneity NSCLC and availability various targeted agents suggest personalized approaches such brain metastases, further development appropriate preclinical models...
<p>Supplementary Figure S1. Histopathology of NSCLC brain metastases and their corresponding PDXs. Histological subtype differentiation status was indicated for each case. ADC = adenocarcinoma, LCC large cell carcinoma, SQCC squamous carcinoma.</p>