A5052023683- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Mosquito-borne diseases and control
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Congenital heart defects research
- Mathematical Biology Tumor Growth
- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Calcium signaling and nucleotide metabolism
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Sirtuins and Resveratrol in Medicine
- Neuroendocrine Tumor Research Advances
- Caveolin-1 and cellular processes
Korea Advanced Institute of Science and Technology
2016-2023
Columbia University Irving Medical Center
2023
Institute for Basic Science
2016
Chonnam National University Hospital
2016
Keio University
2016
Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback well known, positive control augmenting remains poorly understood. Transcription Sox17 indispensable angiogenesis, but its association with largely unknown. The contribution other Sox members to also be determined.To reveal genetic interaction Sox7, another member, in...
In large-scale genomic studies, Sox17, an endothelial-specific transcription factor, has been suggested as a putative causal gene of pulmonary arterial hypertension (PAH); however, its role and molecular mechanisms remain to be elucidated. We investigated the functional impacts acting impaired Sox17 (SRY-related HMG-box17) pathway in PAH explored potential therapeutic target.In adult mice, deletion endothelial cells (ECs) induced under hypoxia with high penetrance severity, but not...
Abstract T-cell position in the tumor microenvironment determines probability of target encounter and killing. CD8+ exclusion from parenchyma is associated with poor response to immunotherapy, yet biology that underpins this distinct pattern remains unclear. Here we show vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised integrity periphery, leading impaired infiltration core. The spatial regulation ANGPT2 whole cross-sections was analyzed conjunction distribution,...
Abstract Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and cells metastasize to distant organs via blood vessels. However, whether invasion vessels remains unknown. As glioblastoma (GBM) featured by aggressive vascular abnormalities, we characterized onset of remodeling in diffuse infiltrating zone establishing new spontaneous GBM models robust capacity. Normal brain underwent a gradual transition severely impaired at periphery...
High-grade glioma (HGG) is highly angiogenic, but antiangiogenic therapy has transient clinical benefit in only a fraction of patients. Vascular regulators these heterogeneous responses remain undetermined. We found up-regulation Sox7 and down-regulation Sox17 tumor endothelial cells (tECs) mouse HGG. deletion suppressed VEGFR2 expression, vascular abnormality, hypoxia-driven invasion, regulatory T cell infiltration, growth. Conversely, exacerbated phenotypes by up-regulating tECs....
Manipulating autophagy is a promising strategy for treating cancer as several inhibitors are shown to induce autophagic cell death. One of these, autophagonizer (APZ), induces apoptosis-independent death by binding an unknown target via mechanism. To identify APZ targets, we used label-free drug affinity responsive stability (DARTS) approach with liquid chromatography/tandem mass spectrometry (LC–MS/MS) readout. Of 35 protein interactors, identified Hsp70 key unmodified in autophagy. Either...
Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half patients with PanNETs present liver metastases, and this accounts for majority patient mortality. We identified angiopoietin-2 (ANGPT2) one most upregulated angiogenic factors RNA-Seq data from human PanNET metastases found that higher ANGPT2 expression correlated poor survival rates. Immunohistochemical staining revealed was localized to endothelial cells blood vessels...
Manipulating autophagy is a promising strategy for treating cancer as several inhibitors shown to induce autophagic cell death. One of these, autophagonizer (APZ), induces apoptosis-independent death by binding an unknown target via mechanism. To identify APZ targets we used label-free drug affinity responsive stability (DARTS) approach with liquid chromatography/tandem mass spectrometry (LC-MS/MS) readout. Of 35 protein interactors, identified Hsp70 key unmodified in autophagy. Either...
<p>Supplemental Figures and Tables</p>
<div>Abstract<p>T cell position in the tumor microenvironment determines probability of target encounter and killing. CD8+ T exclusion from parenchyma is associated with poor response to immunotherapy, yet biology that underpins this distinct pattern remains unclear. Here we show vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised integrity periphery, leading impaired infiltration core. The spatial regulation ANGPT2 whole cross-sections was analyzed...
<p>Supplemental Figures and Tables</p>
<div>Abstract<p>T cell position in the tumor microenvironment determines probability of target encounter and killing. CD8+ T exclusion from parenchyma is associated with poor response to immunotherapy, yet biology that underpins this distinct pattern remains unclear. Here we show vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised integrity periphery, leading impaired infiltration core. The spatial regulation ANGPT2 whole cross-sections was analyzed...
<div>Abstract<p>T-cell position in the tumor microenvironment determines probability of target encounter and killing. CD8<sup>+</sup> T-cell exclusion from parenchyma is associated with poor response to immunotherapy, yet biology that underpins this distinct pattern remains unclear. Here we show vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised integrity periphery, leading impaired infiltration core. The spatial regulation ANGPT2 whole...
<p>Supplemental Figures and Tables</p>
<p>Supplemental Figures and Tables</p>
<div>Abstract<p>T-cell position in the tumor microenvironment determines probability of target encounter and killing. CD8<sup>+</sup> T-cell exclusion from parenchyma is associated with poor response to immunotherapy, yet biology that underpins this distinct pattern remains unclear. Here we show vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised integrity periphery, leading impaired infiltration core. The spatial regulation ANGPT2 whole...
<p>Supplemental Figures and Tables</p>
<p>Supplemental Figures and Tables</p>
Abstract Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and cells metastasize to distant organs via blood vessels. However, whether invasion vessels remains unknown. As glioblastoma (GBM) featured by aggressive vascular abnormalities, we characterized onset of remodeling in diffusive tumor-infiltrating zone establishing new spontaneous GBM models robust capacity. Normal brain underwent a gradual transition severely impaired at...