A5061628907- Histiocytic Disorders and Treatments
- Advanced Fluorescence Microscopy Techniques
- Vascular Tumors and Angiosarcomas
- DNA Repair Mechanisms
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Oral Health Pathology and Treatment
- Digital Holography and Microscopy
- Genital Health and Disease
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Electromagnetic Simulation and Numerical Methods
- Vascular Malformations and Hemangiomas
- S100 Proteins and Annexins
- Cancer therapeutics and mechanisms
- Effects of Radiation Exposure
- Ocular Oncology and Treatments
Severance Hospital
2017-2024
Yonsei University
2007-2024
Dongnam Institute of Radiological & Medical Sciences
2024
Korea Advanced Institute of Science and Technology
2020-2023
Yeungnam University College
2018-2020
Yeungnam University
2018-2020
National Health Insurance Service Ilsan Hospital
2007
The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear. Using large-scale whole-genome sequencing (WGS) clones expanded from irradiated murine and human single cells, we revealed that IR induces characteristic spectrum short insertions or deletions (indels) structural variations (SVs), including balanced inversions, translocations, composite SVs (deletion-insertion, deletion-inversion, deletion-translocation composites), complex...
Abstract Cerebral microinfarct increases the risk of dementia. But how microscopic cerebrovascular disruption affects brain tissue in cellular‐level are mostly unknown. Herein, with a longitudinal intravital imaging, we serially visualized vivo dynamic changes astrocyte, pericyte and neuron as well microvascular integrity after induction cerebral microinfarction for 1 month mice. At day 2–3, it revealed localized edema acute astrocyte loss, neuronal death, impaired pericyte‐vessel coverage...
High‐resolution structural imaging of brain tissue is important for neuroscience research. However, conventional approaches have several limitations, such as the need exogenous staining, limited accessibility to volumetric information, and qualitative analysis. Herein, high‐resolution label‐free analysis mouse are presented using 3D quantitative phase imaging. Measurement refractive index distribution enables direct cellular subcellular structures. Quantification organelles performed in...
Fibrous hamartoma of infancy (FHI) is a rare entity with benign nature. The typical clinical features are single, slowly growing, painless mass on the trunk that appears within first 2 years life. We report 13-month-old boy who presented plaque lower back since 4 months age. had gradually become larger and firm, hyperhidrosis hypertrichosis were noticed. No visible connection between spinal cord lesion was found in radiologic studies, indicating disease other than dysraphism....
Necrobiotic xanthogranuloma (NXG), is a rare multisystem disease that manifests as cutaneous inflammatory lesions, and commonly associated with lymphoproliferative disease. Diffuse normolipemic plane xanthoma (NX), also rare, acquired often systemic diseases such Both of these have been reported to be monoclonal gammopathy (MG). However, there are few cases in which co-exist. A 78-year-old female, who had known case NX on the neck axillary area, presented an asymptomatic erythematous plaque...
Abstract Whole-genome sequencing (WGS) of human tumors and normal cells exposed to various carcinogens has revealed distinct mutational patterns that provide deep insights into the DNA damage repair processes. Although ionizing radiation (IR) is conventionally known as a strong carcinogen, its genome-wide impacts have not been comprehensively investigated at single-nucleotide level. Here, we explored landscape single-cells after exposure levels IR. On average, 1 Gy IR generated ∼16 events...
Abstract Xanthoma disseminatum is a rare form of non‐Langerhans cell histiocytosis with limited treatment options due to its unknown aetiology and diffuse skin lesions. This case report presents the successful 31‐year‐old male severe pan‐facial xanthoma lesions following facial burn traumatic brain injury resulting from car accident. After 5 sessions monthly pulsed dye laser treatment, there was clinically significant reduction in Over course 3 years, patient underwent series treatments,...
Abstract High-resolution structural imaging of brain tissue is important for neuroscience research. However, conventional approaches have several limitations, such as the need exogenous staining, limited accessibility to volumetric information, and qualitative analysis. Herein, we present high-resolution label-free analysis mouse using three-dimensional quantitative phase imaging. Measurement refractive index distribution enables direct cellular subcellular structures. Quantification...
7715 Background: The aim of this study was to evaluate therapeutic outcomes and validate prognostic factors, including adjuvant chemotherapy, in resected thymoma patients who received treatment. Methods: One hundred post-surgical therapy from 1995 2005 were retrospectively reviewed. 55 only radiotherapy for the therapy, while 45 both chemotherapy. total radiation dose 45–63 Gy, with a median 50.4 Gy. chemotherapy consisted 6 cycles doxorubicin, cisplatin, vincristine, cyclophosphamide....
16053 Background: Little is known about the pathogenesis, risk factors, optimal therapy or outcomes of endometrial stromal sarcoma (ESS). The aim this study to evaluate behavior ESS in relation its clinical and pathogenic features find better treatment strategy. Methods: A retrospective analysis was performed 28 patients with histologically proven treated at our institution between 1987 2006. Results: median follow-up time 54.7±63.1 months 5-year survival rate 82.0%. 16 (57.1%) were referred...
Abstract Cerebral microinfarct increases the risk of dementia. But how microscopic cerebrovascular disruption affects brain tissue in cellular-level are mostly unknown. Herein, with a longitudinal intravital imaging, we serially visualized vivo dynamic changes astrocyte, pericyte and neuron as well microvascular integrity after induction cerebral microinfarction for 1 month mice. At day 2-3, it revealed localized edema acute astrocyte loss, neuronal death, impaired pericyte-vessel coverage...
10082 Background: Although the only curative treatment for retroperitoneal sarcoma (RPS) is surgical resection, radiation therapy frequently added. Currently no prospective randomized trial has measured efficacy of neoadjuvant or adjuvant in patients with resected RPS. The purpose this study was to determine effect on overall survival between propensity score-matched, surgically-resected RPS using Surveillance, Epidemiology, and End Results (SEER) database. Methods: population consisted SEER...
7609 Background: To evaluate the efficacy and toxicity of erlotinib in patients (pts) with advanced NSCLC who had progression after treatment gefitinib. Methods: The study included stage IIIB/IV recurrent or metastatic pts have received 2 3 prior chemotherapy regimens showed documented disease during within 4 months Pts 150 mg daily until unacceptable toxicity. We analyzed EGFR mutations other genetic abnormality from available tumor samples. Results: characteristics (n = 21) median age 56...
18177 Background: The efficacy and safety of a combined regimen topotecan etoposide was tested in patients with relapsed or refractory small-cell lung cancer. Methods: From October 2003 to May 2005, 23 who have failed the previous irinotecan platinum chemotherapy received intravenous 1mg/m 2 (day 1–5) followed by 80mg/m 1–3). Treatment repeated every 21 days for maximum 6 cycles. Results: Twelve were first-line chemotherapy. Seventeen (73.9%) male median age 63 years. ECOG performance status...