A5084136889- Hippo pathway signaling and YAP/TAZ
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Genetic and Kidney Cyst Diseases
- Cutaneous lymphoproliferative disorders research
- Renal and related cancers
- Tracheal and airway disorders
- Hair Growth and Disorders
- Hedgehog Signaling Pathway Studies
- melanin and skin pigmentation
- Microtubule and mitosis dynamics
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Skin Protection and Aging
- Protein Kinase Regulation and GTPase Signaling
- Cellular Mechanics and Interactions
- Genetic and rare skin diseases.
- Acne and Rosacea Treatments and Effects
- Wound Healing and Treatments
- Ocular Oncology and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Bartonella species infections research
Korea Advanced Institute of Science and Technology
2017-2023
Yonsei University
2014-2022
Severance Hospital
2015-2022
Korea University
2021
Yonsei University Health System
2015
University Health System
2015
Vanderbilt University
2010
Pohang University of Science and Technology
1994
Phospholipase C-beta 1 (PLC-beta 1) exists as two immunologically indistinguishable polypeptides of 150 and 140 kDa is encoded in rat brain by distinct transcripts 5.4 7.2 kilobases (kb). cDNA corresponding to the entire 5.4-kb transcript reported previously reveals an open reading frame that capable coding a 1216-amino acid polypeptide (Suh, P. G., Ryu, S. H., Moon, K. Suh, H. W., Rhee, G. (1988) Cell 54, 161-169). We have now isolated cDNAs 7.2-kb from library. The differs possessing both...
Acral melanoma commonly occurs in areas that are not exposed to much sunlight, such as the sole of foot. Little is known about risk factors and mutational processes plantar acral melanoma. Nuclear envelope rupture during interphase contributes genome instability cancer. Here, we show nuclear micronuclear membranes cells frequently ruptured by macroscopic mechanical stress on surface due weight-bearing activities. The marginal region nodules exhibits increased morphological abnormalities...
Vitiligo is attributable to loss of functional melanocytes and the most common acquired depigmenting disorder. Oxidative stress intense ultraviolet irradiation are known aggravate this condition. The nonhistone high‐mobility group box 1 (HMGB1) DNA‐binding protein a physiological activator immune responses, cellular proliferation cell death. Although it implicated in pathogenesis autoimmune diseases cutaneous disorders, precise role HMGB1 has yet be studied. To elucidate effect on...
Abstract Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles tumor initiation, progression, metastasis, drug resistance. However, therapeutic targeting of the Hippo–YAP pathway has been challenging due to its low druggability limited knowledge regulation cancer. Here we present a functional screen identify novel target for YAP-driven tumorigenesis. RNAi screening using an oncogenic activation model identified serine/threonine kinase MK5 as positive...
Microtubule-based motors contribute to the efficiency and selectivity of Golgi exit post-Golgi transport membrane proteins that are targeted distinct compartments. Cytoplasmic dynein moves vesicles carry rhodopsin toward base connecting cilium in photoreceptor cells; however, identity involved vesicular trafficking ciliary nonphotoreceptor cells remains unclear. Here, we demonstrate minus end-directed kinesin KIFC1 (kinesin family member C1) is required for both protein serum...
Paraneoplastic pemphigus is a rare, life-threatening autoimmune mucocutaneous blistering disease associated with underlying neoplasia, commonly lymphoproliferative tumors. Herein we report case of paraneoplastic unique autoantibody profile malignant thymoma. A 56-year-old female patient presented relapsing oral ulcerations accompanied by erythematous papules and patches on her extremities for 2 months. Skin mucosal biopsies identified interface dermatitis lichenoid lymphocytic infiltration...
BACKGROUND Obtaining conventional wide surgical margins is challenging in melanomas occurring at anatomically complex sites (e.g., hands and feet). OBJECTIVE We investigated the potential benefits of slow Mohs micrographic surgery (MMS) for acral melanomas. MATERIALS AND METHODS This single-center retrospective study 210 patients who underwent MMS ( n = 66) or local excision (WLE, 144) during 2005 to 2015. Slow was used locations high-risk lesions. RESULTS Acral melanoma (166/210) most...
Abstract Severe alopecia areata ( AA ) can have an unpredictable clinical course and become refractory to contact immunotherapy. Novel treatment options include low‐dose interleukin‐2 Janus kinase inhibitors; however, these treatments are still under investigation. Therefore, we evaluated the efficacy safety of intramuscular (i.m.) triamcinolone acetonide TAC as a rescue therapy for . We retrospectively analysed efficacy, adverse effects relapse rate i.m. monthly in 27 patients with defined...
An isozyme of phosphoinositide-specific phospholipase C (PLC) was purified to near homogeneity from bovine cerebellum by a combination several column chromatography procedures. Approximately 80 micrograms pure enzyme were obtained 4 kg cerebellum, with final specific activity 7.5 mumol/min/mg protein in the presence 0.1% deoxycholate. The is for phosphatidylinositol and 4,5-bisphosphate but does not hydrolyze phosphatidylcholine. molecular weight determined SDS-polyacrylamide gel...
Objective JBTS17 is a major gene mutated in ciliopathies such as Joubert syndrome and oral–facial–digital type VI. Most patients with loss of function mutations exhibit cerebellar vermis hypoplasia brainstem malformation. However, some show microcephaly abnormal gyration. We examined potential roles neurogenesis to understand the pathological mechanism JBTS17‐related cortical abnormalities. Methods subcellular localization cell‐cycle–dependent expression proteins using anti‐JBTS17 antibodies...
Serratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Because of increasing reports antimicrobial resistance, this bacterium has received considerable attention and emerged as an important pathogen. In order reveal clinical microbiological characteristics S. cutaneous infection suggest appropriate antibiotic treatment, we retrospectively analyzed 17 strains isolated from wound swabs Korean patients between November 2005 March 2014. A total 13 (five men...
Serum YKL-40 is an inflammatory biomarker of endothelial dysfunction and may play a role in the process Behçet disease (BD).Serum levels were evaluated patients with BD order to identify associations other cytokines establish laboratory parameters. also compared clinical features activity.In total, 112 45 age- sex-matched healthy volunteers included. Disease activity was assessed Current Activity Form score Electronic Medical Record-based Index (EMRAI) score.Serum significantly higher...
Abstract Melanoma in darker‐pigmented individuals often develops an acral lentiginous fashion on the foot. After surgical removal of a tumor at this site, repair wound can be challenging. This is because there insufficient local skin pool and lack mobility area. Moreover, functional aspects such as walking weight bearing should considered. We performed combination treatment negative pressure therapy (NPWT) punch grafting 15 patients, after wide excision melanomas foot, compared these to 26...
Recent studies highlight that gut dysbiosis, an imbalanced state of intestinal microbiota, exacerbates skin inflammation. Here, we showed the presence microbiota alterations in two patients with recalcitrant acne and investigated impact its therapeutic modulation together gold nanoshell-mediated photothermal therapy (gold PTT).
Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's DiseaseQuadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated disease (BD).However, no reports have described HPV infection as a possible cause for the development of BD.The objective this study was evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased BD.Serum samples from 93 Korean BD patients, who fulfilled diagnostic criteria International Study...
Dear Editor: Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is an autosomal dominant vascular disorder manifested by variable-sized arteriovenous malformations (AVMs) of the skin, central nervous system, and respiratory, gastrointestinal, urogenital tracts1,2. A 43-year-old woman visited our dermatology clinic with a 3-year history increasing numbers purpuric, punctate, tiny macules lip, oral cavity, fingers (Fig. 1A~C). The patient had no...