A5101555001- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Vasculitis and related conditions
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Case Reports on Hematomas
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Nephrotoxicity and Medicinal Plants
- Tracheal and airway disorders
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Ocular Diseases and Behçet’s Syndrome
- Inflammasome and immune disorders
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Autoimmune and Inflammatory Disorders Research
Yonsei University
2013-2018
Severance Hospital
2014-2018
The aim of this study is to assess the actual epidemiologic features Kawasaki disease (KD) in Korea using data from Health Insurance Review & Assessment Service (HIRA) claims 2007 2014. We investigated HIRA patients who had KD (International Classification Diseases-10, M30.3) as a major diagnosis and were given intravenous immunoglobulin (IVIG) A total 39,082 reported during period. male-to-female ratio was 1.42 median age 28 months. incidence rates 168.3 per 100,000 population aged 0 4...
Abstract Objectives Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports elevated serum high mobility group box 1 (HMGB1) level during the phase KD its relationship to poor response IVIG treatment suggest a possible association HMGB1 polymorphisms with KD. We investigated between gene, susceptibility, coronary artery lesions, treatment. Methods Whole genome sequencing gene was performed identify causative variants....
Kawasaki disease (KD) is an acute systemic vasculitis. Both the etiology of KD and erythema Bacille Calmette-Guérin (BCG) injection sites observed in are poorly understood. We investigated association between single nucleotide polymorphisms (SNPs) two candidate genes: inositol 1,4,5-triphosphate 3-kinase (ITPKC), a well-studied KD-associated gene, solute carrier 11a1 (SLC11A1), which associated with hypersensitive reaction to BCG strain Koreans.Associations SNPs genes were evaluated....
During the late autumn to winter season (October December) in Republic of Korea, respiratory syncytial virus (RSV) is most common pathogen causing lower tract infections (LRTIs). Interestingly, 2014, human coronavirus (HCoV) caused not only upper but also LRTIs more commonly than other years. Therefore, we sought determine epidemiology, clinical characteristics, outcomes, and severity illnesses associated with HCoV at a single center Korea.We retrospectively identified patients positive...
Intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD). However, there still no IVIG-resistant KD. This study aimed to evaluate efficacy of low-dose methotrexate (MTX) as a KD.We retrospectively analyzed 10-year data patients with KD who were administered MTX at Severance Children's Hospital.The subjects included 75 aged 5 months 9.2 years had been MTX. Their maximum body temperatures decreased significantly within 24 h therapy. The patients' C-reactive protein...
Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's DiseaseQuadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated disease (BD).However, no reports have described HPV infection as a possible cause for the development of BD.The objective this study was evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased BD.Serum samples from 93 Korean BD patients, who fulfilled diagnostic criteria International Study...
Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It mainly seen in young children under the age of five. KD multifactorial disorder that includes genetic variants. The present study investigated association between and single nucleotide polymorphisms (SNPs) candidate gene early B cell factor 2 (EBF2), which associated with inflammation markers. An SNP analysis was performed by whole exon sequencing EBF2 gene. Our comprised total 495 subjects (295 patients 200 unrelated normal...
Purpose: Despite withdrawal of RotaShield ® and the development second generation live attenuated rotavirus vaccines, concerns remain regarding relationship between vaccine intussusception.Nevertheless, since there is no study in Korea, we reviewed data from cases at Severance Children's Hospital to determine association intussusception.Materials Methods: Patients coded as intussusception following a prescription RotaTeq 2007 2013 were reviewed.We calculated comparative incidence figures...
Sensorineural hearing loss (SNHL) that is seldom cited as a Kawasaki disease (KD) complication known an additional, potentially severe, and frequently irreversible sequel. Furthermore the vestibular functions of KD have been underestimated it could be important combined with SNHL in KD. We described case 4 year-old boy who developed has recovered successfully treatment. Keywords: · Labyrinthitis loss.
DiGeorge syndrome is an immunodeficient disease associated with abnormal development of 3rd and 4th pharyngeal pouches. As a hemizygous deletion chromosome 22q11.2 occurs, various clinical phenotypes are shown broad spectrum. Conotruncal cardiac anomalies, hypoplastic thymus, hypocalcemia the classic triad syndrome. this characterized by or aplastic there missing thymic shadow on their plain chest x-ray. Immunodeficient patients traditionally known to be at increased risk for malignancy,...
Henoch-Schonlein purpura (HSP) is a vasculitis that involves small vessels and seen in children predominantly. Main symptoms are purpuric rashes on body, especially lower extremities, arthralgia, abdominal pain, nephritis. Uncommonly, nervous system can be involved.
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Kawasaki disease (KD) is an acute systemic vasculitis syndrome that predominantly affects children younger than 5 years of age, and may causes serious, sometimes life-threatening, cardiac sequela associated with coronary artery aneurysm (CAA). To identify genetic variants confers a highly increased risk aneurysm-related in disease. In this study, we carried out genome-wide association study (GWAS) Korean population including 102 CAA-related KD cases 126 controls. Fifteen loci were found to...
Purpose: Subacute sclerosing panencephalitis (SSPE) is a neurodegerative disease due to persistent measles virus infection. We investigated the role of programmed death-1 (PD-1) molecule which related with chronic viral infection in developing SSPE mouse. Methods: adopt , and wild type BALB/c 3 week old mice make an animal model by injecting (SSPE strain) intraventricularly. Three months after infusion virus, were sacrificed examined if typical pathologic lesions had been progressed. The...