A5101945018- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Histone Deacetylase Inhibitors Research
- Rheumatoid Arthritis Research and Therapies
- Genomics, phytochemicals, and oxidative stress
- Spondyloarthritis Studies and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Social and Behavioral Studies
- Carcinogens and Genotoxicity Assessment
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Apelin-related biomedical research
- Cancer Risks and Factors
- Pelvic floor disorders treatments
- Testicular diseases and treatments
- Head and Neck Anomalies
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Gestational Trophoblastic Disease Studies
- IgG4-Related and Inflammatory Diseases
- Computational Drug Discovery Methods
Kyungpook National University Hospital
2015-2018
Kyungpook National University
2015-2017
Keimyung University
2003-2017
Keimyung University Dongsan Medical Center
2012-2014
Georgetown University
2007
Georgetown University Medical Center
2007
Objective: To measure the prognostic value of lymphocyte-monocyte ratio (LMR) in patients with epithelial ovarian cancer (EOC).Methods: We retrospectively examined LMR as a prognosticator cohort 234 EOC who underwent surgical resection.Patients were categorized into two different groups based on (LMR-low and LMR-high) using cut-off values determined by receiver operating characteristic (ROC) curve analysis.The objective study was to assess effect progression-free survival (PFS) overall (OS),...
Hepatocellular carcinoma (HCC) is a worldwide health problem and it important to understand the mechanistic roles of biomolecules involved in its pathogenesis. Long non-coding RNAs (lncRNAs) are frequently aberrantly expressed various human cancers known play role cancer The aim this study was analyze expression lncRNA-ATB HCC investigate implications for prognoses. In total, 100 samples tissues their corresponding, adjacent, non-cancerous liver were collected. Total extracted levels...
Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP). Pulse-chase experiments showed the increase in BaP-induced knockdown cells may not be associated BRCA1's function nucleotide excision repair activity; rather, it its modulating transcriptional regulation. MCF-10A significantly attenuated induction of CYP1A1 following BaP treatment indicating is dependent. However, our study shows defective still able to biotransform regulating other CYP...
This study evaluated the efficacy of extended field irradiation (EFI) in patients with locally advanced cervical cancer without para-aortic nodal involvement.A total 203 (International Federation Gynecology and Obstetrics [FIGO] stage, IB2-IIIB) treated radiotherapy at Keimyung University Dongsan Medical Center from 1996 to 2010 were retrospectively analyzed. The median patient age was 59 years (range, 29 83 years). None had node metastases. Of patients, 88 underwent EFI 115 pelvis only....
OBJECTIVE: The purpose of the present study was to determine prognostic significance neutrophil-lymphocyte ratio (NLR) in recurrence cervical intraepithelial neoplasia (CIN). METHODS: We evaluated NLR as a marker entire cohort 230 patients who had undergone surgical resection and were diagnosed with CIN. Subjects categorized into two different groups based on (NLR-high NLR-low) using cutoff values determined by receiver operating characteristic (ROC) analysis. primary research objective for...
Sodium butyrate (NaBT) is principally a histone deacetylase (HDAC) inhibitor, and it has the potential to arrest HPV-positive carcinoma cells at G1 S phase transition of cell cycle. The aim study was determine whether phosphatidylinositol 3-kinase (PI3K) inhibition can enhance inhibitory effect NaBT on human cervical cancer line (HeLa).Cervical (HeLa) were treated with alone or in combination PI3K inhibitors wortmannin LY294002. Cell viability analysis FACS carried out. expressions cycle...
The optimal endoscopic screening interval for early gastric cancer (EGC) detection still remains controversial. Thus, we performed this prospective study to clarify the between examinations EGC detection. A questionnaire survey penultimate endoscopy and (GC) diagnosis was used; findings were then analyzed. patients divided into two groups according GC type intervals. total of 843 enrolled. (P < 0.001), tumor location size histology stage treatment modality 0.001) showed significant...
Objective The aim of this study was to investigate the anti-proliferative effect salinomycin in cell proliferation and apoptosis primary cultured human uterine leiomyoma cells. Methods Cell viability measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Caspase-3 activity assay DNA fragmentation were performed determine apoptosis. expression regulatory-related proteins evaluated western blot. Results cells significantly reduced treatment a dose-dependent...
The aim of the present study was to evaluate in vitro effect a heat shock protein (Hsp)90 inhibitor, SY-016, on paclitaxel (PTX)-resistant human ovarian cancer cell line OVCAR-3PTX, and explore its mechanism apoptosis. In study, SY-016 used combination with PTX determine proliferation apoptosis OVCAR-3PTX cells. drug-resistant tumor cells were established by stepwise sequential exposure increasing concentrations PTX. viability cycle distribution measured MTT assay flow cytometric analysis,...
Objective: This clinical study was to evaluate the patients' and pathological characteristics treatment results in women with ovarian granulosa cell tumor. Methods: A made on 31 cases of tumor that were treated at department Obstetrics Gynecology Keimyung University Dongsan Medical Center between January 1997 December 2005. Clinical characteristics, results, follow-up data for collected retrospectively from medical records. Results: The mean age patients 49 years (24 86 years). chief...
Purpose To investigate the prognostic factors and effectiveness of postoperative radiotherapy alone for endometrial carcinoma. Materials Methods Sixty four patients with stage I-III cancer (EC) treated between January 1989 December 2008 at Keimyung University Dongsan Medical Center were chosen present study. Typically, total hysterectomy, salpingo-oophorectomy lymphadenectomy performed on patient's pelvis. Total dose from 50.4 Gy to 63 was irradiated pelvis or extended field. Thirteen Co-60...
Objective : To evaluate whether mTOR inhibition by rapamycin can enhance the inhibitory effect of sodium butyrate, a histone deacetylase (HDAC) inhibitor on human cervical cancer cell line HeLa. Methods Cervical cells (HeLa) were treated with butyrate alone or in combination rapamycin. Cell viability was analyzed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTS) assay and flow cytometry performed to ascertain effects combinations Expression cycle related proteins evaluated...
ê¸ì± ì¬ê·¼ê²½ìì ììë ì ì ì°ë ¹ììë ë§¤ì° ë문 ì§íì´ì§ë§ ëªëª 기ì ì§íì ê°ì§ê³ ìë ê²½ì° ê·¸ ë°ë³ë¥ ì´ ì¦ê°í ì ìê³ ì ì¦íêµ°ë ìì¸ ì¤ì íëì´ë¤. ì¦íêµ°ìì ëíëë ìê³ íì§ìíì ë맥경íì ì íê° ì¬ê·¼ê²½ìì ìì¸ì¼ë¡ ìëê³ ìë¤. 본 ì¦ë¡ë ì ì¡°ì ëì§ ìë 미ì¸ë³í ì¦íêµ°ì ê°ì§ë íììì ë°ìí ì¬ì¸ì± ì¼í¬ë¥¼ ëë°í STìì¹ ì¬ê·¼ê²½ìì ë³´ê³...
Correspondence to Eon Jeong Nam, M.D. Department of Internal Medicine, Kyungpook National University School 130 Dongdeok-ro, Jung-gu, Daegu 700-721, Korea Tel: +82-53-420-5493, Fax: +82-53-426-2046, E-mail: ejnam@knu.ac.kr Copyrightc 2015 The Korean Association Medicine This is an Open Access article distributed under the terms Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and...
Secondary tricuspid regurgitation (TR) primarily develops due to left heart failure or primary pulmonary diseases. Tricuspid annular dilation, which is commonly caused by right ventricular volume and pressure overload followed ventricle believed be the main mechanism underlying secondary TR. It reported that once annulus dilated, its size cannot spontaneously return normal, it may continue dilate. These reports also suggest use of an aggressive surgical approach for In present report, we...
í¼ë¶ê·¼ì¼ì ê·¼ìë¶ ê³¨ê²©ê·¼ì ìì½ê° ë° í¹ì§ì ì¸ í¼ë¶ë³ë³ì 주ìë¡ íë ì¼ì¦ì± ìê°ë©´ìì§íì¼ë¡ì ëë¶ë¶ íì¤ CK ìì¹ì ëë°íë¤. ì±ì¸ í¼ë¶ê·¼ì¼ìì ì§ë°©ì¸µì¼ì´ ììì ì¼ë¡ ë°íëë ê²½ì°ë ë물ë¤. ì´ì ì ìë¤ì ì§ë°©ì¸µì¼ì ëë°íê³ ìì¹ ìì´ ììíì ê·¼ì¡ ì¡°ì§ê²ì¬ìì ëª ë°±í ê·¼ì¼ì´ íì¸ë í¼ë¶ê·¼ì¼ 1ì를 ê²½ííì기ì 문íê³ ì°°ê³¼ í¨ê» ë³´ê³ ë°ì´ë¤. ì¤ì¬...
Background Ankylosing spondylits (AS) is a chronic inflammatory spondyloarthritis characterized by prominent axial ankylosis, peripheral arthritis, and enthesopathy. The Bath Spondylitis Metrology Index (BASMI), metrologic assessment of spinal mobility, well correlated with the change inflammation soft tissue involvement. Disease Activity Score (ASDAS), which incorporates CRP or ESR values in addition to patient-reported outcome (PRO) measurements, new composite index assess disease activity...
Primary fallopian tube carcinoma is one of the rarest gynecological malignancies, accounting for 0.18% to 1.6% all malignant neoplasms female reproductive tract.Preoperative diagnosis was difficult due nonspecific symptoms and signs.This case primary tubal cancer diagnosed preoperatively on basis ultrasonography, computed tomography magnetic resonance imaging.We have experienced a before operation so report with brief review literature.
Choriocarcinoma is a rapidly growing tumor that characteristically outgrows its blood supply.We report rare case of metastatic choriocarcinoma presenting with acute right flank pain due to kidney rupture secondary renal metastasis.The metastasis was embolised stanch for control hemorrhage.A brief review the imaging features and therapeutic options ruptured metastases discussed along case.